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Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
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Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
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Journal Article
Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
2009
Overview
This study from four Australian centers examined whether low-dose, continuous oral antibiotic therapy would prevent urinary tract infection in children (under the age of 18 years) who had already had one or more microbiologically proven urinary tract infections. Long-term, low-dose trimethoprim–sulfamethoxazole was associated with a modest decrease in the number of urinary tract infections in predisposed children.
Long-term, low-dose trimethoprim–sulfamethoxazole was associated with a modest decrease in the number of urinary tract infections in predisposed children.
Urinary tract infection is a very common illness in children, affecting 2% of boys and 8% of girls by the age of 7 years.
1
Urinary tract infection is associated with long-term morbidity, with renal damage reported in about 5% of affected children.
2
The observation that urinary tract infection and vesicoureteral reflux are associated with renal damage
3
–
5
led to the standard clinical practice of assessment with voiding cystourethrography for the presence of vesicoureteral reflux in children who had had urinary tract infection
6
,
7
and the administration of daily low-dose antibiotics for many years
8
to prevent further urinary tract infections and . . .
Publisher
Massachusetts Medical Society
Subject
/ Anti-Infective Agents, Urinary - administration & dosage
/ Anti-Infective Agents, Urinary - adverse effects
/ Anti-Infective Agents, Urinary - therapeutic use
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Bacterial diseases of the urinary system
/ Biological and medical sciences
/ Child
/ Female
/ Humans
/ Infant
/ Male
/ Pharmacology. Drug treatments
/ Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage
/ Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects
/ Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
/ Urinary Tract Infections - epidemiology
/ Urinary Tract Infections - etiology
/ Urinary Tract Infections - prevention & control
/ Vesico-Ureteral Reflux - classification
