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In order to understand the in vitro drug release of the produced gel, the goal of the current investigation was to construct and characterize. Acitretin loaded Solid Lipid Nanoparticles (ActSLNs). Act SLNs were created utilizing the Box Benhken design and the hot homogenization procedure. Act SLN's average diameter and surface morphology were assessed. Act SLNs were lyophilized, then they underwent stability testing, powder X-Ray diffraction, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) tests to characterize them. The SLNs were added to a 0.25% w/w Carbopol 940 gel base the Stability study, ex vivo drug release in vitro drug releases in rat skin were carried out. The optimized Act SLNs had a spherical form, an entrapment efficiency of 78.82% to 85.73%, and an average particle size of 123.24nm to 409nm. The generation of SLNs was confirmed by DSC, FTIR, and XRD data. ActSLN gel (0.056mg/cm2) significantly increased the amount of accutane deposited in rat skin compared to Act plain gel (0.012mg/cm2).No discernible change was found in the stability studies, according to stability studies.

4 mg/ 100 ml at 25°C), which limits its dissolution and consequently its bioavailability. [...]it is important to enhance the solubility and dissolution rate of Leflunomide to improve its oral bioavailability. Phase solubility analysis of Leflunomide: Phase solubility study was done to determine the stoichiometric proportion of Leflunomide with complexing agent ß-CD. Inclusion complexes prepared by kneading method showed higher saturation solubility than those prepared by other methods8,9. 3) IR spectral analysis: IR Spectra of pure drug and inclusion complexes of Leflunomide with ß-CD prepared by different methods are given in Fig. 1. The spectra of inclusion complexes and physical mixtures of components revealed disappearance of characteristic peaks of aromatic C-H stretching, N-H stretching and Amide at 3250 cm-1, 3400 cm-1 and 1670 cm-1respectively. [...]it suggests that vibrating and bending movements of guest molecule that is Leflunomide were restricted due to formation of inclusion complex.

Formulations were analyzed using Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD) analysis, Fourier Transform-Infrared spectroscopy (FT-IR) and in-vitro release studies followed by various release kinetics. The solid dispersion is defined as dispersion of one or more active ingredients in an inert carrier matrix at solid-state prepared by the melting (fusion), solvent evaporation or melting-solvent method.1 Gelucires are a family of lipid-based excipients comprising glycerides and esters of (PEG), these two components conferring hydrophobic and hydrophilic properties to the vehicle. Powder X ray Diffraction: PXRD pattern of the solid dispersion prepared with Gelucire was characterized by less intensity of diffraction peaks as compared to pure drug, suggesting conversion of microcrystalline form of the drug to an amorphous state, which may helps to improve solubility and dissolution of drug (Fig. 1 and 2).17, 18,19,22,25 Factorial Design: Response surface plot for cumulative % drug release in 15 minutes and for disintegration time is as shown in Figure No.3, 4. The enhanced drug release rates of solid dispersions (SDs) may be due to many factors such as decreased particle size of drug, specific form of drug in these SDs, in addition to the increase in drug wettability.

The aim of recent study was to develop highly precise RP-HPLC method for estimation of eletriptan hydrobromide in pharmaceutical formulation, RP-HPLC method was developed using Alligent-1100 C18 column (Chemstation-32 software) at 30°c with flow rate of 1.0ml/min. at detection wavelength of 234nm with UV visible detector. The method was validated as per ICH guidelines and various validation parameters like accuracy, precision, limit of detection (LOD), Limit of Quantification (LOQ), recovery study and range were determined. The proposed method was simple, rapid, precise, and accurate, and can be used for routine analysis of eletriptan hydrobromide in bulk and combinations the method was found to be linear in the range of 5-30 mcg/ml with coefficient relation of 0.9998.

The objective of this study was to develop modified release dosage forms of tramadol hydrochloride using wax matrix system by melt granulation method. The effect of various waxes, concentration of waxes, effect of excipients on the release profile of drug from wax matrix system was studied. Release retardant effect was observed in the order of hydrogenated vegetable oil (HVO) > compritol >precirol. This may be due to more lipophilicity imparted by HVO than any other waxy substances. It was also observed that as ratio of drug: Wax was increased, it sustained release of drug for more time. This may be due to proper embedment/entrapment of drug in sufficient wax matrix system. In case of excipients, release retardant effect was found in order of dicalcium phosphate (DCP) > microcrystalline cellulose (MCC) > lactose. DCP is insoluble which helps in release retardation of drug. MCC is hydrophilic swellable polymer which showed release of drug by swelling. Lactose is soluble excipient which get dissolved and formed channels for entry of dissolution medium and release of drug occurred by erosion mechanism. Wax matrix tablets were found to be stable.

The pathogenic relationship between the oral lichenoid reaction (OLR) and dental restorative materials has been confirmed many times. An OLR affecting oral mucosa in direct contact with an amalgam restoration represents a delayed, type IV, cell mediated immune response to mercury or one of the other constituents of the dental amalgam. Bombay blood group patients are more prone to this. A case of bilateral OLR is presented, which is present in relation to amalgam restoration. The lesion healed up after the replacement of restorations with an intermediate restorative material. The clinician should be aware of all the possible pathological etiologies of white lesions. If there is any doubt about the nature or management of a usual oral lesion, a referral to an appropriate specialist is mandatory.