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Relying on longitudinal microdata from a Spanish rural region between 1750 and 1950 (almost 35,000 life courses), this article provides evidence that discriminatory practices affected sex‐specific mortality during infancy and childhood. Although it is likely that families also discriminated against girls during the first year of life, female excess mortality was especially visible in the 1–5 age group. While breastfeeding seems to have temporarily mitigated the effects of gender discrimination, sex‐specific mortality rates behaved very differently once children were weaned. Parents, therefore, prioritized boys during infancy and childhood in the allocation of food and/or care in order to enhance their survival chances.

Polyamines (PAs) constitute a group of low molecular weight aliphatic amines that have been implicated as key players in growth and development processes, as well as in the response to biotic and abiotic stresses. Transgenic plants overexpressing PA-biosynthetic genes show increased tolerance to abiotic stress. Therein, abscisic acid (ABA) is the hormone involved in plant responses to environmental stresses such as drought or high salinity. An increase in the level of free spermine (Spm) in transgenic Arabidopsis plants resulted in increased levels of endogenous ABA and promoted, in a Spm-dependent way, transcription of different ABA inducible genes. This phenotype was only partially reversed by blocking ABA biosynthesis, indicating an ABA independent response mediated by Spm. Moreover, the phenotype was reproduced by adding Spm to Col0 wild-type Arabidopsis plants. In contrast, Spm-deficient mutants showed a lower tolerance to salt stress. These results indicate that Spm plays a key role in modulating plant stress responses.

The Roman world was diverse and complex. And so were religious understandings and practices as mirrored in the enormous variety presented by archaeological, iconographic, and epigraphic evidence. Conventional approaches principally focus on the political role of civic cults as a means of social cohesion, often considered to be instrumentalized by elites. But by doing so, religious diversity is frequently overlooked, marginalizing 'deviating' cult activities that do not fit the Classical canon, as well as the multitude of funerary practices and other religious activities that were all part of everyday life. In the Roman Empire, a person's religious experiences were shaped by many and sometimes seemingly incompatible cult practices, whereby the 'civic' and 'imperial' cults might have had the least impact of all. Our goal therefore is to rethink our methodologies, aiming for a more dynamic image of religion that takes into account the varied and often contradictory choices and actions of individual, which reflects the discrepant religious experiences in the Roman world. Is it possible to 'poke into the mind' of an individual in Roman times, whatever his/her status and ethnicity, and try to understand the individual's diverse experiences in such a complex, interconnected empire, exploring the choices that were open to an individual? This also raises the question whether the concept of individuality is valid for Roman times. In some periods, the impact of individual actions can be more momentous: the very first adoption of Roman-style sculpture, cult practices or Latin theonyms for indigenous deities can set in motion long-term processes that will significantly influence people's perceptions of local deities, their characteristics, and functions. Do individual choices and preferences prevail over collective identities in the Roman Empire compared to pre-Roman times? To examine these questions, this volume presents case studies that analyze individual actions in the religious sphere.

This research addresses the growing social importance of data from an educational perspective through data literacy (DL), seeking to integrate it into the broader information literacy (Infolit) movement. For this purpose, a systematic review was carried out of the papers in the main collection of the Web of Science that contain both concepts (DL and Infolit) and that were indexed up until March 2023. External aspects, such as the growth of the research and the identity, nationality, professional scope, and productivity of the authors, were taken into account. In addition, internal aspects, such as context (theory, frameworks, definitions, models, and related disciplines), objectives, methodology, results, conclusions, and recommendations, were analyzed to obtain a detailed perspective of the scientific research process adopted. A synchronic and diachronic analysis of the corpus of selected articles is offered, focusing on the aforementioned aspects. The researchers’ consensus on the urgency of addressing data training both generally and specifically in the different disciplines, languages, environments, and levels is evident. The emergent, multisectoral, and interdisciplinary nature of data literacy as part of Infolit, which is being applied in the education of students at different levels, viz. professionals and citizens, is noted, although the training limitations of students and many professionals are evident. Consequently, it is imperative to include DL in curricula and training programs to contribute to the acquisition and development of these competencies in different areas. To this end, the joint work of teachers, librarians, researchers, and other professionals is imperative. There is a need to deepen the theoretical, practical, and applied fields, as well as to reach a common definition, form a basic model of DL competencies within Infolit, and create submodels that take into consideration the idiosyncrasies of each area of application.

Main conclusion: For the first time we provide a study on the physiological, ultrastructural and molecular effects of salt stress on a terrestrial symbiotic green microalga, Trebouxia sp. TR9. Although tolerance to saline conditions has been thoroughly studied in plants and, to an extent, free-living microalgae, scientific data regarding salt stress on symbiotic lichen microalgae is scarce to non-existent. Since lichen phycobionts are capable of enduring harsh, restrictive and rapidly changing environments, it is interesting to study the metabolic machinery operating under these extreme conditions. We aim to determine the effects of prolonged exposure to high salt concentrations on the symbiotic phycobiont Trebouxia sp. TR9, isolated from the lichen Ramalina farinacea. Our results suggest that, when this alga is confronted with extreme saline conditions, the cellular structures are affected to an extent, with limited chlorophyll content loss and photosynthetic activity remaining after 72 h of exposure to 5 M NaCl. Furthermore, this organism displays a rather different molecular response compared to land plants and free-living halophile microalgae, with no noticeable increase in ABA levels and ABA-related gene expression until the external NaCl concentration is raised to 3 M NaCl. Despite this, the ABA transduction pathway seems functional, since the ABA-related genes tested are responsive to exogenous ABA. These observations could suggest that this symbiotic green alga may have developed alternative molecular pathways to cope with highly saline environments.

Introduction Childhood obesity is a public health problem with repercussions in later life. As tissue formation peaks in childhood we determined how weight status influences bone mineral content. Material and methods We studied 553 children aged 4–18 years over 10 years (46.8% girls). We measured age, weight, height and through bone densitometry (DXA), bone mineral content (BMC), bone mineral density (BMD), and waist, arm and hip circumferences. The patients were divided into groups using the body mass index z-score: underweight, normal weight, overweight, obese and very obese. Results BMC and BMD values were highest in the normal-weight and overweight groups. Logistic regression showed bone mineralization was inversely associated with waist circumference, the association being positive for weight and age. No differences were found according to sex. Discussion Studies of the relationship between weight and bone mineralization report contradictory results, often because of different study designs. Moreover, studies in children are either few or with small samples. Our findings in a large sample show the importance of weight status in bone mineralization given the risk of bone fractures or osteoporosis. Conclusions Weight status influenced bone mineralization. BMC and BMD decreased in children with a higher degree of obesity. Waist circumference correlated negatively with bone mineralization.

Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-α, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-β) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42.3%). Compared to patients with psoriasis alone, those with NAFLD were significantly more likely to have metabolic syndrome, diabetes, dyslipidemia, body mass index ≥ 30 kg/m 2 , homeostatic model assessment of insulin resistance ≥ 2.15, and greater psoriasis area severity index. NAFLD patients also had significantly higher levels of TNF-α (p = 0.002) and TGF-β (p = 0.007) and a higher prevalence of bacterial translocation (29.7% vs. 13.7%; p = 0.004). Liver stiffness measurement was over 7.8 kPa in 17.2% (15/87) of NAFLD patients; 13 of these underwent liver biopsy, and 5.7% (5/87) had liver fibrosis, while 1.1% (1/87) had advanced fibrosis or non-alcoholic steatohepatitis. In conclusion the prevalence of NAFLD in patients with psoriasis is high and associated with a higher prevalence of metabolic syndrome features, bacterial translocation and a higher pro-inflammatory state. It is worth mentioning that liver fibrosis and non-alcoholic steatohepatitis are not frequent in this population of patients.

Rabbit is a reflexively ovulating species. Accordingly, in the practice of artificial insemination (AI) ovulation must be induced via exogenous GnRH (Gonadotropin-Releasing Hormone) administration, which may be performed intramuscularly, subcutaneously, or intravaginally. Unfortunately, the bioavailability of the GnRH analogue when added to the extender is lower due to the proteolytic activity in the seminal plasma and the poor permeability of the vaginal mucosa. The aim of the study was to refine the practice of AI practice in rabbits by replacing parenteral GnRH analogue administration (subcutaneous, intravenous, or intramuscular injection) with intravaginal application, while reducing its concentration in the diluent. Extenders containing the buserelin acetate in chitosan–dextran sulphate and chitosan–alginate nanoparticles were designed and 356 females were inseminated. Reproductive performance of females inseminated with the two experimental extenders, receiving 4 μg of buserelin acetate intravaginally per doe, was compared with that in the control group, the does of which were inseminated with the extender without the GnRH analogue and induced to ovulate with 1 μg of buserelin acetate administered intramuscularly. The entrapment efficiency of the chitosan–dextran sulphate complex was higher than that of chitosan–alginate. However, females inseminated with both systems showed similar reproductive performance. We conclude that both nanoencapsulation systems are an efficient way of intravaginal ovulation induction, allowing a reduction in the level of the GnRH analogue normally used in seminal doses from 15–25 μg to 4 μg.

Genetic resource banks (GRB) are a valuable tool for maintaining genetic variability and preserving breeds from pathogens or catastrophe, enabling us to assess and correct breeding schemes, minimizing the impact of genetic drift and facilitating diffusion. This study tests their efficiency in re-establishing two extinct populations of a synthetic rabbit line selected for daily weight gain, using vitrified embryos from two generations (18th and 36th) separated by 15 years of genetic selection. The effect of long-term storage of vitrified embryos in liquid nitrogen was also evaluated. A total of 516 vitrified embryos using the same protocol were transferred into 54 recipients. The embryos had been maintained in liquid nitrogen during 2 different periods, (i) 1 year (301 embryos and 26 transfers, 36th generation) and (ii) 15 years (259 embryos and 28 transfers, 18th generation). A total of 80.0% (8/10 to 18th) and 60.0% (9/15 to 36th) of the foundational sire families were eventually re-established. Over approximately one year, animals within each population were crossed to produce the next generation and re-establish the original population size. Our study demonstrated that our GRB of embryos vitrified 15 years ago is a successful strategy to re-establish rabbit populations to continue the breeding programme.

After 39 generations of selection, a commercial paternal rabbit line, utilised by farmers through artificial inseminations with sperm from males in a three-way crossbreeding scheme based on average daily weight gain merit (ADG), present a deleterious effect on the reproductive performance. This poses a challenge for the continuation of the breeding program. To address this, our study employed repeated backcrossing, a strategy widely used in the recovery of endangered breeds, to improve the litter size traits of this paternal line. For this purpose, we used a maternal line characterised by its reproductive robustness merit (LP line). The study was conducted in two phases: initially, elite males from the R line were crossed with females from the LP line, and female offspring (BC1) were backcrossed twice with elite males from the R line to create the RLP population (BC3). The best sires and dams from the BC3 population were selected for breeding based on two phenotypically criteria: more than 50 g/day in ADG and being part of a litter with at least 7 live kits at weaning, over three generations. With this experimental design, the ADG merit of sires and dams in the G3 was more than 51 g/day. Regarding litter traits, significant improvements were observed due to heterosis, which diminished as the frequency of R line genes increased. Comparisons between BC1 and BC3 backcrosses showed 9.94 vs. 7.80 for litter size at birth (NB), 9.13 vs. 6.53 for number born alive (NBA), 7.19 vs. 4.99 for litter size at weaning (NW), and 5.65 vs. 4.54 for litter size at marketing (NM), respectively. Nevertheless, after three generations of selection (G3), the litter trait merit showed values of 7.46 for NB and 6.15 for NBA, with heritability of 0.12 and 0.11, respectively, resulting in an improvement of nearly 1 kit per parity (a 25% increase) compared to the R line. Our study illustrated the possibility of improving a rabbit paternal line in terms of litter size merit by integrating genes from a maternal line through three backcrosses, without compromising the ADG merit. This is crucial for extending our breeding program beyond the current 39 generations.HIGHLIGHTSThree backcrossing resulting in an improvement of nearly 1 kit per parityBackcrossing can enhance litter size merit without affecting growth rates.Progeny average daily gain merit remains stable across backcrossing efforts.