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Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
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Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
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Journal Article
Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
2021
Overview
Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-α, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-β) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42.3%). Compared to patients with psoriasis alone, those with NAFLD were significantly more likely to have metabolic syndrome, diabetes, dyslipidemia, body mass index ≥ 30 kg/m
2
, homeostatic model assessment of insulin resistance ≥ 2.15, and greater psoriasis area severity index. NAFLD patients also had significantly higher levels of TNF-α (p = 0.002) and TGF-β (p = 0.007) and a higher prevalence of bacterial translocation (29.7% vs. 13.7%; p = 0.004). Liver stiffness measurement was over 7.8 kPa in 17.2% (15/87) of NAFLD patients; 13 of these underwent liver biopsy, and 5.7% (5/87) had liver fibrosis, while 1.1% (1/87) had advanced fibrosis or non-alcoholic steatohepatitis. In conclusion the prevalence of NAFLD in patients with psoriasis is high and associated with a higher prevalence of metabolic syndrome features, bacterial translocation and a higher pro-inflammatory state. It is worth mentioning that liver fibrosis and non-alcoholic steatohepatitis are not frequent in this population of patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/699
/ Adult
/ Bacteria
/ Bacterial Translocation - physiology
/ Biopsy
/ Diabetes Mellitus - metabolism
/ Diabetes Mellitus - microbiology
/ Diabetes Mellitus - pathology
/ Female
/ Fibrosis
/ Humanities and Social Sciences
/ Humans
/ Insulin
/ Insulin Resistance - physiology
/ Liver
/ Liver Cirrhosis - metabolism
/ Liver Cirrhosis - microbiology
/ Male
/ Metabolic Syndrome - metabolism
/ Metabolic Syndrome - microbiology
/ Metabolic Syndrome - pathology
/ Non-alcoholic Fatty Liver Disease - metabolism
/ Non-alcoholic Fatty Liver Disease - microbiology
/ Non-alcoholic Fatty Liver Disease - pathology
/ Science
