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Hart–SLSA Prize for Early Career Academics, Socio-Legal Studies Association Ways of Belonging examines the experiences of undocumented young people who are excluded from K–12 schools in Canada and are rendered invisible to the education system. Canadian law doesn't mention the existence of undocumented children, and thus their access to education rests on discretionary practices and is often denied altogether. This book brings the stories of undocumented young people vividly alive, putting them into conversation with the perspectives of the different actors in schools and courts who fail to include these young people. Drawing on long-term ethnographic fieldwork, Francesca Meloni shows how ambivalence shapes the lives of young people who are caught between the desire to belong and the impossibility of fully belonging. Meloni pays close attention to these young people's struggles and hopes, showing us what it means to belong and to endure in contexts of social exclusion. Ways of Belonging reveals the opacities and failures of a system that excludes children from education and puts their lives in invisibility mode. An interview with the author [https://www.qmul.ac.uk/clpn/news-views/book-interviews/items/interview-with-francesca-meloni-about-her-book-ways-of-belonging-undocumented-youth-in-the-shadow-of-illegality.html] (https://www.qmul.ac.uk/clpn/news-views/book-interviews/items/interview-with-francesca-meloni-about-her-book-ways-of-belonging-undocumented-youth-in-the-shadow-of-illegality.html)

Tyrosinase, a key protein in the biosynthesis of melanin pigments, is crucial in determining skin pigmentation. Inhibiting tyrosinase activity is a promising approach for treating conditions related to excessive pigmentation. For the synthesis of more potent tyrosinase inhibitors, we combined two approaches, para-substitution and lipophilicity, to enhance the inhibitory properties of (E)-2-(4-hydroxybenzylidene)hydrazine-1-carbotiamide, whose enzyme inhibitory properties have been previously demonstrated. The newly synthesized compounds showed potent inhibition activity against tyrosinase in the micromolar concentration range. The synthesised compounds were up to 41 times more effective than kojic acid. In addition to this biological activity, all molecules were evaluated for their sun protection factor to determine their photoprotective effects. All the compounds showed higher efficacy than reference compounds, used as sunscreens in photoprotective preparations. All compounds were noncytotoxic at the concentration required to inhibit tyrosinase activity. With the aim of defining the potential binding modes and the kind of interactions between the studied molecules and the catalytic site of mushroom tyrosinase, molecular docking simulations were also performed.

A heteroleptic [Ru(terpy)2]2+ (terpy = 2,2′:6′,2″-terpyridine) complex was electrochemically polymerized to give the corresponding metal-containing conducting polymer on gold and glassy carbon electrodes. The polymerization of the Ru(II) complex was allowed by a terthiophene functionalization on one of the two terpy coordinating fragments, whereas the presence of -COOH substituents on the second terpy ligand enabled the film to immobilize a tyrosinase enzyme by cross-linking with glutaraldehyde. Then, the Ru(terpy) conducting polymer worked as a transducer as well as an immobilizing agent in the design of amperometric biosensors for the determination of epinephrine. The electrochemical behavior of enzymatic sensors containing Ru(terpy)-based conducting polymers was investigated by differential pulse voltammetry and chronoamperometry. Analytical performances and kinetic parameters were calculated, suggesting a potential application of the reported biosensors in the determination of epinephrine in pharmaceutical products.

How do undocumented young people establish a sense of belonging when they are afraid to disclose their migratory status? And when they could be separated from the persons they love and care for? Drawing on ethnographic fieldwork conducted in Canada, this article explores how illegality shapes youth's belonging. It argues that the experiences of undocumented youth, as well as the attitudes of the state towards them, must be understood as forms of \"structural ambivalence. \" On the one hand, I show how marginality is reproduced not only through explicit policies of exclusion (e.g., deportation, surveillance, or immigration documents), but also through laws and practices that are often silent and opaque, rendering people non-existent at a social and legal level. On the other, I analyze how youth negotiate such discourses of invisibility by forming a revocable sense of belonging. I suggest that ambivalence is not only produced by the social exclusion of young people. It is also a form of agency which enables youth to endure the risk of deportation, and to detach themselves from the disempowering conditions they are caught in.

The 2-(2,7-bis(pyridin-3-ylethynyl)fluoren-9-ylidene)malononitrile (1) was synthesized by reaction of 2,7-bis(pyridin-3-ylethynyl)fluoren-9-one with malononitrile in DMSO solution. The structural characterization of 1 by SC-XRD analysis was accompanied by elemental analysis, FT-IR, NMR, and MS measurements.

How do undocumented young people establish a sense of belonging when they are afraid to disclose their migratory status? And when they could be separated from the persons they love and care for? Drawing on ethnographic fieldwork conducted in Canada, this article explores how illegality shapes youth's belonging. It argues that the experiences of undocumented youth, as well as the attitudes of the state towards them, must be understood as forms of \"structural ambivalence. \" On the one hand, I show how marginality is reproduced not only through explicit policies of exclusion (e.g., deportation, surveillance, or immigration documents), but also through laws and practices that are often silent and opaque, rendering people non-existent at a social and legal level. On the other, I analyze how youth negotiate such discourses of invisibility by forming a revocable sense of belonging. I suggest that ambivalence is not only produced by the social exclusion of young people. It is also a form of agency which enables youth to endure the risk of deportation, and to detach themselves from the disempowering conditions they are caught in.

BackgroundThis study evaluated the efficacy of pressurized intraperitoneal aerosol chemotherapy (PIPAC) with systemic chemotherapy as a bidirectional approach for gastric cancer (GC) patients with synchronous peritoneal metastases (SPM).MethodsA retrospective analysis of a prospective PIPAC database was queried for patients who underwent a bidirectional approach between October 2019 and April 2022 at two high-volume GC surgery units in Italy (Verona and Siena). Surgical and oncological outcomes were analyzed.ResultsBetween October 2019 and April 2022, 74 PIPAC procedures in 42 consecutive patients with Eastern Cooperative Oncology Group performance status ≤2 were performed—32 patients treated in Verona and 10 in Siena. Twenty-seven patients (64%) were female and median age at first PIPAC was 60.5 years (I–III quartiles: 49–68 years). Median Peritoneal Cancer Index (PCI) was 16 (I–III quartiles: 8–26) and 25 patients (59%) had at least two PIPAC procedures. Major complications according to the Common Terminology Criteria for Adverse Events (CTCAE; 3 and 4) occurred in three (4%) procedures, and, according to the Clavien–Dindo classification (>3a), one (1%) severe complication occurred. There were no reoperations or deaths within 30 days. Median overall survival (mOS) from diagnosis was 19.6 months (range 14–24), and mOS from first PIPAC was 10.5 months (range 7–13). Excluding cases with very heavy metastatic peritoneal burden, with PCI from 2 to 26, treated with more than one PIPAC, mOS from diagnosis was 22 months (range 14–39). Eleven patients (26%) underwent curative-intent surgery after a bidirectional approach. R0 was achieved in nine (82%) patients and complete pathological response was obtained in three (27%) cases.ConclusionsPatient selection is associated with bidirectional approach efficacy and feasibility for SPM GC treatment, which may allow potentially curative surgical radicalization in highly selected cases.