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Paracetamol is a wide analgesic drug used without prescription especially after the COVID-19 pandemic without attention to its potential side effects and toxicities risks. Paracetamol overdose can cause oxidative organs injury mainly liver and kidney being the most difficult medical conditions increasing through the years especially in Egypt. Although bee products prolonged used as medicine in ancient Egypt due to their well-known health properties, there are a limited studies on clover honey. So, this study compared the protective effects of Egyptian clover honey, a cheap and popular type, alone or enhanced with 3% different bee products (propolis, pollen, royal jelly and their equal mix) (5g/kg b.w.) vs. silymarin (50 mg/kg b.w.) as antioxidant drug against some toxic effects of paracetamol overdose (650 mg/kg b.w.) in rats for 2 weeks. Also, honey chemical composition, total phenols and flavonoids and antioxidant activity plus sensory evaluation of jams made of honeys were done. Adding different bee products to honey enlargement its total phenols, antioxidant activity and nutritional profile as raises protein, ash, fat and fiber while carbohydrates were reduced. Enhanced honey with different bee products attenuated paracetamol oxidative and inflammation effects as nitric oxide and malondialdehyde reduction plus total antioxidant increase leading to reno-hepatoprotective with best effect for honey plus pollen and mix, while honey with royal jelly was the strongest uric acid lowering effect. Also, improvements in lipids profile and atherogenic indices were detected by best effects for honey with propolis and mix. Honey group results reached to healthy group and silymarin drug which is sometimes more effective. Additionally, jams sensory evaluation made of honey showed good acceptability, keeping its texture without smoothing the surface or saccharification indicating good technological properties than sucrose jam, plus lovely flavor of honey with pollen jam which is near to clove. Although enhanced honey can be used as it is or even added to the water for health purposes but including it within different foods enhances their consumption. These findings highlight the detoxified effects of supported Egyptian clover honey with different bee products against paracetamol toxicity which still need more specific searches to prove and detect the perfect type of honey and bee products, effective safe dose, form, and period toward these respects considering the variation in bioactive components and their mechanisms, plus new technological food applications.

Apricot kernels are rich in protein and fat, and many anti-cancer compounds. The current study was designed to examine the potential impact of apricot kernel powder (AKP) on rats with cancerous livers induced by potassium bromate. Thirty adult male albino rats, with an average weight of 150±10 g, were divided randomly into two main groups. Group 1 was given a standard diet and served as the negative control group (normal rats). Group 2 was administered a single intraperitoneal dose of potassium bromate at 125 mg/kg body weight to induce oxidative stress and follicular cells, then divided into 4 subgroups. Group 2 remained as the positive control group and received only the standard diet, while groups 3, 4, and 5 were given AKP at concentrations of 10%, 20%, and 30%, respectively. Throughout the 28-day experimental period, each rat's weight was monitored individually, and at the end of the study period, the rats were euthanized, and blood samples were collected. Biological and biochemical parameters were evaluated, and the potential cytotoxic activity against liver carcinoma cell line was measured. The outcomes demonstrated inhibition and repression at consume of AKP at some tumor parameter, as Interferons alpha (IFN-alpha), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), Protein carbonyl oxidation (PCO), Alpha-fetoprotein (AFP) and improving at oxidative parameters and liver function and lipid profiles. The best results were for groups fed with 30% of AKP.

A prevalent health concern, osteoporosis is characterized by mass loss and structural degradation of bone structure., Thus, the aim of this study is repressing glucocorticoid stimulated osteoporosis in male rats by using different doses of thyme powder (TP) .Thirty male albino rats were separated into five groups (6 rats each): G1, control negative fed balanced diet; G2, control positive fed balanced diet and injected with prednisolone (10mg/kg per daily); G3, G4, and G5 were also injected with prednisolone (10mg/kg daily) throughout the experiment in addition to being given different doses of TP 2.5, 5 and 7.5%, respectively of the basal diet weight. After 28-day, Blood samples were taken at the conclusion of the experiment to evaluate bone femur status and blood osteoporosis markers. The findings showed that TP accelerated the increase in body weight. Different doses of TP raised significantly the serum Ca, Mg, OC, and DPD, while the serum P, interleukin 6, PTH, and CRP significantly decreased. The femur's bone ash contents, primarily in calcium and phosphorus, and bone mineral density both showed significant improvements. In conclusion, the moderate use of thyme improves bone growth and serum indicators of osteoporosis, it may be helpful for preventing osteoporosis in rats.