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"Nicks, Mike"
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Extracellular Superoxide Dismutase Attenuates Lipopolysaccharide-Induced Neutrophilic Inflammation
Abstract
Extracellular superoxide dismutase (EC-SOD) is an abundant antioxidant in the lung and vascular walls. Previous studies have shown that EC-SOD attenuates lung injury in a diverse variety of lung injury models. In this study, we examined the role of EC-SOD in mediating lipopolysaccharide (LPS)-induced lung inflammation. We found that LPS-induced neutrophilic lung inflammation was exaggerated in EC-SOD–deficient mice and diminished in mice that overexpressed EC-SOD specifically in the lung. Similar patterns were seen for bronchoalveolar lavage cytokines, such as tumor necrosis factor–α, keratinocyte-derived chemokines, and macrophage inflammatory protein-2 as well as expression of lung intercellular adhesion molecule–1, vascular cell adhesion molecule–1, endothelial cell selectin, and platelet selectin. In a macrophage cell line, EC-SOD inhibited LPS-induced macrophage cytokine release, but did not alter expression of intercellular adhesion molecules in endothelial cells. These results suggest that EC-SOD plays an important role in attenuating the inflammatory response in the lung most likely by decreasing release of proinflammatory cytokines from phagocytes.
Journal Article
Byrne ready to defy a broken hand in title defence
\"You come to a rest in the gravel trap and you know you've broken something,\" he said. \"But your first thought is, 'When can I get back on the bike?' It makes you realise you love this sport so much. It makes you even hungrier. It's a blessing because it makes you push even harder.\" \"I'm old enough to be his dad, but [Jake Dixon] to me is another rival,\" [Shane Byrne] said. \"I'm so determined every time we go out cycling or to the gym. I want to do heavier weights and a better time on the bike, and I want to beat him up every climb.\" Byrne's refusal to succumb could pay off. The final pre-season test session took place at a cold and slippery Donington last week - hardly the circumstances in which you would expect an injured rider to shine. But far from looking vulnerable, Byrne lapped fastest. Tomorrow he confronts a qualifying session, and then the big show on Monday. After that the series takes in 11 more rounds before the finale at Brands Hatch in October.
Newspaper Article
Lorenzo moves up a gear in bid to stop Marquez hat-trick
MotoGP fans will be hoping to see anyone other than the reigning champion Marc Marquez on top of the podium when the first race of the 18-round series - motorcycle racing's equivalent of Formula One - finishes in Qatar on Sunday. This year his chief rival, the 27-year-old Spaniard Jorge Lorenzo, starts the series fully fit, and armed with a seamless-shift gearbox in his 1000cc Yamaha YZR-M1. A seamless shifter means that Lorenzo will not have to touch the clutch lever as he moves up and down his six-speed transmission, and it could pare perhaps three-tenths of a second - a significant saving for a MotoGP rider - from a 1min 55sec lap on the 3.375-mile Losail circuit. \"We are trying to raise our level so that we can arrive at the same level as Marquez,\" [Valentino Rossi] says. \"I will try to improve the braking and corner entry, and I'm still working on changing my position on the bike.\"
Newspaper Article
Lorenzo makes it a thriller but Marquez still supreme
In the Honda pit box Marquez's Catalan father, Julia, who had bought his boy his first 50cc motorcycle at the age of three, covered his mouth with his hand because of the tension produced by the closeness of this duel at speeds of up to 200mph. Marquez duly pulled off his coup, flailing his rear wheel from side to side like a speedway rider as he took the lead for the first time on the 14th lap. But only two laps later he ran wide on a corner and Lorenzo sped through the gap. Scott Redding, 21, was the highest British finisher in 10th place, a result that might appear unspectacular but will boost his chances of getting a more powerful bike next year. His Gresini Honda is a lease-hire version of Honda's RC213V, and not the factory-honed edition Marquez rides. The MotoGP circus now heads for the 13th round at Misano, San Marino. Lorenzo will be heartened by the way that he and Yamaha were able to take the battle to Marquez. But it is still a huge hill to climb. Marquez pulls off stunts on a MotoGP bike that nobody else can match, and he is still improving. It has been a great show for nearly two seasons, but now the novelty of the relentless winning is starting to pall. Would you prefer to see the Premier League settled a month before the close of the season or do you want the outcome to be poised until the last weekend?
Newspaper Article
Marquez back in the groove to take pole at Silverstone
\"My qualifying lap was not as fast as last year, because the track is a bit slower,\" [Marc Marquez] said. \"But I'm really happy with the bike.\" The 28-year-old Italian Andrea Dovizioso will start from second, only a third of a second slower than Marquez, in a Ducati revival that has seen his V4 on the front row for the last three races.
Newspaper Article
Marquez rewriting rule book to reign in MotoGP
\"We developed the elbow slider because [Marc Marquez] was damaging his leathers in the corners and it was a time- consuming update every time we had to make a replacement,\" Alpinestars' Jeremy Appleton says. \"Now it's simply a question of tearing off and replacing the protectors at the end of a day's racing.\" [Santi Hernandez], who partnered Marquez to the 2012 Moto2 championship for 600cc bikes and to last year's MotoGP title, probably knows his rider as well as anyone. \"The elbow on the asphalt is a style that Marc started to do because it's natural for him,\" Hernandez says. \"It gives him another reference point to know where his limit is.\" It is certainly true that Honda has given Marquez the most effective machine on the MotoGP grid this year. The combination of the Spaniard's flair and Japanese technology has landed him with a 77-point lead over his nearest rival, his Repsol Honda team-mate Dani Pedrosa. A second world championship is all but in Marquez's palm, but the crowds still flock to MotoGP circuits to see him weave his special brand of alchemy.
Newspaper Article
THE BEST OF BOTH WORLDS
Surtees never managed to attract the big-money sponsorship that would have allowed him to fight for the F1 Constructors' Championship, but nevertheless his TS series of cars started 260 times in 119 F1 races during those years, their 40 drivers including familiar names such as Rene Arnoux, Derek Bell, Mike Hailwood, Alan Jones, Jochen Mass, John Watson and Surtees himself.
Newspaper Article
ICING ON THE CAKE
The car and motorcycle legend John Surtees will celebrate his 80th birthday on Tuesday, in an atmosphere far from the world of camshafts, wheelspin and screaming exhaust notes that has made him famous. After the quiet family gathering, the ever-restless king of two and four wheels will return to Britain to swing into a series of appearances at motorsport events and fundraising activities for his charity, the Henry Surtees Foundation.
Newspaper Article