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Extracellular Superoxide Dismutase Attenuates Lipopolysaccharide-Induced Neutrophilic Inflammation
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Extracellular Superoxide Dismutase Attenuates Lipopolysaccharide-Induced Neutrophilic Inflammation
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Journal Article
Extracellular Superoxide Dismutase Attenuates Lipopolysaccharide-Induced Neutrophilic Inflammation
2004
Overview
Abstract
Extracellular superoxide dismutase (EC-SOD) is an abundant antioxidant in the lung and vascular walls. Previous studies have shown that EC-SOD attenuates lung injury in a diverse variety of lung injury models. In this study, we examined the role of EC-SOD in mediating lipopolysaccharide (LPS)-induced lung inflammation. We found that LPS-induced neutrophilic lung inflammation was exaggerated in EC-SOD–deficient mice and diminished in mice that overexpressed EC-SOD specifically in the lung. Similar patterns were seen for bronchoalveolar lavage cytokines, such as tumor necrosis factor–α, keratinocyte-derived chemokines, and macrophage inflammatory protein-2 as well as expression of lung intercellular adhesion molecule–1, vascular cell adhesion molecule–1, endothelial cell selectin, and platelet selectin. In a macrophage cell line, EC-SOD inhibited LPS-induced macrophage cytokine release, but did not alter expression of intercellular adhesion molecules in endothelial cells. These results suggest that EC-SOD plays an important role in attenuating the inflammatory response in the lung most likely by decreasing release of proinflammatory cytokines from phagocytes.
Publisher
Am Thoracic Soc,Oxford University Press
Subject
/ Bronchoalveolar Lavage Fluid
/ Bronchus
/ Extracellular Fluid - enzymology
/ Female
/ Gene Expression Regulation, Enzymologic
/ Humans
/ Intercellular Adhesion Molecule-1 - metabolism
/ Lavage
/ Lipopolysaccharides - pharmacology
/ Lungs
/ Macrophage inflammatory protein
/ Male
/ Mice
/ Reverse Transcriptase Polymerase Chain Reaction
/ Superoxide Dismutase - metabolism
/ Superoxide Dismutase - pharmacology
