Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
145
result(s) for
"Noda Satoru"
Sort by:
Golden kamuy. 4
\"Tetsuzo Nihei, the legendary Bear Killer, is determined to become the hunter who kills Retar, the last remaining Ezo wolf. Asirpa will never allow this, and she and Immortal Sugimoto race to stop his bloodthirsty quest. Meanwhile, Hijikata, one of the former leaders of the Shinsengumi, assembles a band of death-row escapees to go after the Ainu gold, bringing him face-to-face with Lt. Tsurumi and his 7th Division. In this clash of iron wills, only the strongest can survive.\"--Page [4] of cover.
Book
Predictive Value of Neutrophil/Lymphocyte Ratio for Efficacy of Preoperative Chemotherapy in Triple-Negative Breast Cancer
Background
The neutrophil/lymphocyte ratio (NLR) has been reportedly associated with prognosis in cancer patients by influencing both cancer progression and chemosensitivity. However, the correlation between NLR and the outcome of neoadjuvant chemotherapy (NAC) in breast cancer patients remains unclear.
Methods
NLR was evaluated in 177 patients with breast cancer treated with NAC with 5-fluorouracil, epirubicin, and cyclophosphamide, followed by weekly paclitaxel and subsequent curative surgery. The correlation between NLR and prognosis, including the efficacy of NAC, was evaluated retrospectively.
Results
NLR ranged from 0.5 to 10.6. Fifty-eight patients with low NLR (<3.0) had a higher pathological complete response (pCR) rate (
p
< 0.001) and were more frequently diagnosed with ER-negative/progesterone receptor (PR)-negative/HER2-negative (triple-negative) breast cancer (TNBC;
p
< 0.001) compared with patients with high NLR (≥3.0). Among TNBC patients who achieved pCR, disease-free survival (
p
= 0.006) and overall survival (
p
< 0.001) were significantly longer in patients with low NLR than in those with high NLR. Low NLR was associated with a significantly favorable prognosis in TNBC patients who achieved pCR, according to univariate analysis (
p
= 0.044, hazard ratio = 0.06).
Conclusions
Low NLR may indicate high efficacy and favorable outcome after NAC in patients with TNBC.
Journal Article
Golden kamuy. 5
\"Sugimoto and Asirpa's hunt for the tattooed treasure map has led them to a fishing village on the coast, where a deranged serial killer lies in wait. Lt. Tsurumi and his renegade soldiers are also hot on their trail, and if he catches up to them there will be guaranteed hell to pay. Toshizo Hijikata also closes in while an old friend shows up with a secret about Asirpa that no one wants to believe--but it just might take them closer to the gold than ever before...\"--Page [4] of cover.
Book
Use of Tumor-infiltrating lymphocytes (TILs) to predict the treatment response to eribulin chemotherapy in breast cancer
Eribulin mesylate (eribulin) is currently indicated for treatment of locally advanced or metastatic breast cancer (MBC). It is a cytotoxic agent with unique mechanisms that suppress epithelial-mesenchymal transition (EMT) of cancer cells. On the other hand, Tumor-infiltrating lymphocytes (TILs), which are considered indicators of immune response monitoring, have been reported as prognostic factors and predictors of therapeutic efficacy. We thought that eribulin, which has an EMT-inhibiting mechanism, may produce an antitumor effect by improving the immune microenvironment, and in this study investigated the effects of breast cancer eribulin chemotherapy on the immune microenvironment with TILs as a marker.
TILs was evaluated in 52 patients with MBC who underwent chemotherapy with eribulin. The correlation between TILs evaluated according to the standard method, and prognosis, including the efficacy of eribulin chemotherapy, was investigated retrospectively.
Of the 52 MBC patients, 29 (55.8%) were in the high TILs group and 23 (44.2%) were in the low TILs group. The high TILs group included significantly more triple-negative breast cancer (TNBC) (p = 0.008) than the low TILs group. In an analysis of outcomes, TNBC patients in the high TILs group had significantly longer disease-free survival than TNBC patients in the low TILs group (p = 0.033, log-rank), but no significant differences were seen in all breast cancer patients (p = 0.489, log-rank) or in non-TNBC patients (p = 0.878, log-rank). In a multivariate analysis of recurrence in TNBC patients, being in the high TILs group was again an independent factor for a good outcome (p = 0.031, HR = 0.063).
The results of this study suggest that TILs may be useful as a predictive marker of the therapeutic effect of eribulin chemotherapy in TNBC.
Journal Article
Golden kamuy. 7
\"As Sugimoto and his friends continue their journey to the northernmost reaches of Hokkaido and the infamous Abashiri prison, they meet the enigmatic and beautiful Ainu soothsayer, Inkarmat, in an Ainu village along the way. Shiraishi jumps at the chance to get rich off Inkarmat's predictions, though Asirpa doesn't have much use for them. But what fate has Inkarmat seen for Sugimoto and Asirpa that she would tell them they're better off giving up the search for the lost gold?\"--Back cover.
BOOK
Platelet–Lymphocyte Ratio as a Useful Predictor of the Therapeutic Effect of Neoadjuvant Chemotherapy in Breast Cancer
The peripheral blood platelet-lymphocyte ratio (PLR) has been proposed as an indicator for evaluating systemic inflammatory responses in cancer-bearing patients. While some reports suggest a correlation between PLR and prognosis, few studies have examined the relationship between PLR and sensitivity to chemotherapy. We conducted a study on whether PLR could serve as a predictor of the therapeutic effects of neoadjuvant chemotherapy (NAC).
PLR was evaluated in 177 breast cancer patients treated with the NAC 5-fluorouracil, epirubicin and cyclophosphamide, followed by weekly paclitaxel and subsequent curative surgery. The correlation between PLR and prognosis, and between PLR and the efficacy of NAC, were evaluated retrospectively.
The low PLR group had significantly more patients > 56 years old (p = 0.001) and postmenopausal women (p = 0.001) than the high PLR group. The low PLR group also had a higher pathologic complete response (pCR) rate (p = 0.019). On examining the correlation with prognosis, the low-PLR group was found to have significantly longer disease-free survival (p = 0.004) and overall survival (p = 0.032) than the high PLR group. Multivariate analysis also revealed that lymph node metastasis (p = 0.043, hazard ratio = 4.40) and a high PLR (p = 0.005, hazard ratio = 2.84) were independent, unfavorable prognostic factors.
For patients with breast cancer treated with NAC, a low PLR indicated high chemotherapy sensitivity, suggesting that PLR could serve as a predictive marker of the therapeutic effect of NAC.
Journal Article
Golden kamuy
In the early 20th century, Russo-Japanese War veteran Saichi Sugimoto searches the wilderness of the Japanese frontier of Hokkaido for a hoard of hidden gold. With only a cryptic map and a native Ainu girl to help him, Saichi must also deal with every murderous cutthroat, bandit and rogue who knows about the treasure!
Book
Visualizing “featureless” regions on mammograms classified as invasive ductal carcinomas by a deep learning algorithm: the promise of AI support in radiology
PurposeTo demonstrate how artificial intelligence (AI) can expand radiologists’ capacity, we visualized the features of invasive ductal carcinomas (IDCs) that our algorithm, developed and validated for basic pathological classification on mammograms, had focused on.Materials and methodsIDC datasets were built using mammograms from patients diagnosed with IDCs from January 2006 to December 2017. The developing dataset was used to train and validate a VGG-16 deep learning (DL) network. The true positives (TPs) and accuracy of the algorithm were externally evaluated using the test dataset. A visualization technique was applied to the algorithm to determine which malignant findings on mammograms were revealed.ResultsThe datasets were split into a developing dataset (988 images) and a test dataset (131 images). The proposed algorithm diagnosed 62 TPs with an accuracy of 0.61–0.70. The visualization of features on the mammograms revealed that the tubule forming, solid, and scirrhous types of IDCs exhibited visible features on the surroundings, corners of the masses, and architectural distortions, respectively.ConclusionWe successfully showed that features isolated by a DL-based algorithm trained to classify IDCs were indeed those known to be associated with each pathology. Thus, using AI can expand the capacity of radiologists through the discovery of previously unknown findings.
Journal Article
Golden kamuy. 9
\"After their run-in with the mad taxidermist Edogai, Asirpa, Sugimoto and Shiraishi still have unfinished business in Yubari. But if their goal is to meet Noppera-bo face-to-face, they will need to hear Shiraishi's story about how he first earned the nickname 'Escape King'. Toshizo Hijikata would also like to have a little chat with them regarding Nopperi-bo, and then there is the matter of the 7th Division, whose members are closing in\"--Back cover.
BOOK
Sorafenib inhibits vascular endothelial cell proliferation stimulated by anaplastic thyroid cancer cells regardless of BRAF mutation status
Anaplastic thyroid cancer (ATC) is a rare refractory disease, frequently associated with BRAF mutations and aberrant vascular endothelial growth factor (VEGF) secretion. The antitumor effects of sorafenib were evaluated, and its mechanisms of action were investigated. Four human ATC cell lines were used: OCUT-4, which possesses a BRAF mutation; OCUT-6 and ACT-1, which carry NRAS mutations; and OCUT-2, which possesses mutations in BRAF and PI3KCA. The viability of Sorafenib was evaluated by MTT assay. In order to examine the inhibitory effect of Sorafenib on intracellular signal transduction, expression of mitogen-activated protein kinase kinase was examined by western blotting. In addition, cell cycle analysis was performed using flow cytometry. The inhibitory effects of sorafenib on the growth of ATC cells and human umbilical vein endothelial cells (HUVECs) stimulated with conditioned media from ATC cells were examined. Sorafenib inhibited the viability of OCUT-4 more effectively than other ATC cell lines; these effects may have been mediated cytostatically by suppressing mitogen-activated protein kinase kinase phosphorylation. Conversely, similar suppression was not observed in OCUT-6 cells, which possess an NRAS mutation. The four cell lines secreted different quantities of VEGF, and the proliferation of HUVECs was differentially stimulated by their conditioned media. Both anti-VEGF antibody and sorafenib prevented this stimulation of proliferation. In conclusion, sorafenib more effectively inhibited RAF-generated growth signals in ATC cells compared with signals generated by its upstream gene, RAS. ATC cells stimulated the growth of HUVECs via humoral factors, including VEGF; this effect was clearly inhibited by sorafenib. The present findings highlighted the potential of sorafenib for the treatment of ATC and provided insight into its mechanism of action.
Journal Article