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"Offit, Paul A"
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Bivalent Covid-19 Vaccines — A Cautionary Tale
Bivalent Covid-19 VaccinesSince the rollout of bivalent vaccine boosters targeting omicron subvariants, research has suggested they don’t elicit superior immune responses as compared with monovalent boosters. What happened?
Journal Article
On the Shoulders of Giants — From Jenner’s Cowpox to mRNA Covid Vaccines
The FDA recently authorized two mRNA vaccines for the prevention of Covid-19. Clearance of this hurdle represents the most recent in a series of advances in the realm of viral vaccines, each building on the last and each with a compelling record of disease prevention.
Journal Article
Vaccines and Autism: A Tale of Shifting Hypotheses
Although child vaccination rates remain high, some parental concern persists that vaccines might cause autism. Three specific hypotheses have been proposed: (1) the combination measles-mumps-rubella vaccine causes autism by damaging the intestinal lining, which allows the entrance of encephalopathic proteins; (2) thimerosal, an ethylmercury-containing preservative in some vaccines, is toxic to the central nervous system; and (3) the simultaneous administration of multiple vaccines overwhelms or weakens the immune system. We will discuss the genesis of each of these theories and review the relevant epidemiological evidence.
Journal Article
Bad advice : or why celebrities, politicians, and activists aren't your best source of health information
\"Science doesn't speak for itself. Neck-deep in work that can be messy and confounding ... in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of ... information, Americans are more confused than ever about what's good for them and what isn't. [This book] shares wisdom on the dos and don't of battling [this] misinformation\"--Amazon.com.
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Covid-19 Boosters — Where from Here?
On December 10, 2020, Pfizer presented results from a 36,000-person, two-dose, prospective, placebo-controlled trial of its Covid-19 messenger RNA (mRNA) vaccine, BNT162b2, to the Food and Drug Administration (FDA).
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The vaccine was 95% effective at preventing severe illness in all age groups, independent of coexisting conditions or racial or ethnic background. A remarkable result. Six months later, studies showed that protection against severe disease was holding up.
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The results of these epidemiologic studies were consistent with those of immunologic studies showing long-lived, high frequencies of Covid-19–specific memory B and T cells, which mediate protection against severe disease.
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In September 2021, . . .
Journal Article