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"Pawłowska, Małgorzata"
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Effect of drill cuttings addition on physicochemical and chemical properties of soil and red clover (Trifolium pretense L.) growth
The most economical method of drill cuttings disposal may be their application in land reclamation which allows for the wastes recovery. However, the wastes application into the soil should ensure that the quality of the environment would not be deteriorated. These investigations were aimed at identifying the effect of drill cuttings, which were the mixture of different types of drilling wastes, on the physicochemical properties of acidic soil and growth of red clover ( Trifolium pratense L.). The experimental design comprised 5 treatments, which differed in a dose of the drill cuttings: 0% (control), 2.5%, 5%, 10% and 15% of dry weight. A six-week pot experiment was conducted to determine the influence of the wastes on the plant growth. The results showed that the drill cuttings addition significantly changed the chemical and physicochemical properties of the soil, such as: electrical conductivity (EC), pH, base saturation, content of carbonate, alkaline cations (Ca 2+ , Na + , K + , Mg 2+ ), organic matter, total organic carbon (TOC), and available phosphorus form. However, the most important factors that influenced the growth of red clover were pH, base saturation, content of Mg 2+ and plant available phosphorus. The red clover biomass was increased from 1.5 to 2.5 times depending on the dose of wastes. We concluded that the examined wastes can be used for reclamation of the acid and unfertile degraded soils, but the amount of wastes should not exceed 5% of the soil, because the highest total clover biomass was observed just at this dose.
Journal Article
State and Perspectives of Biomethane Production and Use—A Systematic Review
In the face of increasingly frequent natural disasters resulting from climate change and disruptions in the supply chains of energy resources, the demand for energy carriers based on locally sourced renewable resources is growing. Biomethane, derived from biomass and having multiple uses in the energy sector, fully meets these conditions. Analyses of the development and spatial distribution of biomethane production plants, the prevalence of methods of its production, and directions of applications, made on the basis of the data gained from official databases and research papers, are the main subjects of the paper. Additionally, the advantages and disadvantages of biomethane production, taking into account the results of the life cycle assessments, and the prospects for development of the biomethane market, facing regulatory and policy challenges, are considered. The results of the review indicate that biomethane production is currently concentrated in Europe and North America, which together generate over 80% of the globally produced biomethane. An exponential growth of the number of biomethane plants and their production capacities has been observed over the last decade. Assuming that the global strategies currently adopted and the resulting regional and national regulations on environmental and socio-economic policies are maintained, the further intensive development of the biomethane market will be expected in the near future.
Journal Article
Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18—Optimization, Characterization, and Cosmetic Application
Solid lipid nanoparticles (SLNs) incorporated with retinol and oligopeptide can have a full spectrum of effects on the skin as a compatible combination of ingredients with broad anti-aging properties. The research’s main objective was to ensure the stability of lipid nanocarriers containing retinol and peptide due to the planned use of this dispersion as a cosmetic raw material. To confirm the effectiveness of method optimization (high shear homogenization, HSH) and proper selection of substrates, SLN dispersions were obtained in three combinations: 1—non-incorporated SLNs; 2—SLNs containing only retinol; 3—SLNs containing retinol and pentapeptide-18; these were then stored at different temperatures (4, 25, 45 °C) for 4 weeks. The desired values of the physicochemical parameters of the optimized dispersion of lipid nanoparticles incorporated with retinol and oligopeptide over the required storage period were confirmed: mean particle size (Z-Ave) = 134.7 ± 0.3 nm; polydispersity index (PDI) = 0.269 ± 0.017 [−]; zeta potential (ZP) = 42.7 ± 1.2 mV (after 4 weeks at 25 °C). The results confirmed the proper selection of the SLN production method and the effectiveness of the optimization performed. The possibility of using the obtained raw material as an ingredient in cosmetic products with anti-aging properties was indicated.
Journal Article
Potential Drug Interactions in Psychiatric Patients Undergoing Pangenotypic Therapy for Hepatitis C Virus Infection
Over the past decade, significant progress has been made in the treatment of chronic hepatitis C virus (HCV) infection. The introduction of direct-acting antivirals (DAAs) has revolutionized the treatment of HCV infection, offering nearly 100% efficacy. Furthermore, additional therapeutic regimens with pangenotypic efficacy have been registered. These drugs are also characterized by a few adverse events and good treatment tolerance. As DAA therapy is now accessible to virtually all patients, including those with multimorbidity who often take multiple medications, drug interactions (DDIs) have become a significant clinical challenge. One of the groups of patients who are frequently infected with HCV is those with mental disorders. Due to frequently overlapping metabolic pathways, DDIs can occur, affecting the effectiveness of both psychiatric and antiviral therapy. Knowledge of these interactions is crucial in these cases and influences patient management. This paper discusses the most significant interactions between pangenotypic DAA regimens and psychotropic medications.
Journal Article
Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children
Purpose. The aim of this study was to evaluate the diagnostic and prognostic value of IL-6 and sTREM-1 in the course of SIRS and sepsis in children with reference to routinely used CRP and PCT. Methods. A prospective study included 180 patients at the ages from 2 months to 18 years hospitalized due to fever from November 2015 to January 2017. Forty-nine children without fever hospitalized due to noninfectious causes formed the control group. IL-6 and sTREM-1 serum concentrations were assessed with the enzyme-linked immunosorbent assay method. Results. The mean serum concentrations of all the analyzed biomarkers were statistically significantly higher in the study group compared to the control group. Mean IL-6, sTREM-1, and PCT serum concentrations were statistically significantly higher in the group of patients with SIRS/sepsis compared to the group of feverish patients without diagnosed SIRS (N-SIRS). Based on the ROC curve analysis, it was shown that of all the biomarkers tested, only two—IL-6 and procalcitonin—had potential usefulness in the diagnosis of SIRS/sepsis in children with fever. Conclusion. Elevated levels of IL-6 and PCT are important risk factors for the development of SIRS/sepsis in children with fever. It seems that elevated IL-6 baseline serum level may predict a more severe course of febrile illness in children, because based on the ROC curve analysis, it was found that IL-6 is a statistically significant prognostic marker of prolonged fever≥3 days and prolonged hospitalization>10 days. The assessment of the usefulness of sTREM-1 in the diagnosis of SIRS/sepsis in feverish children requires further research.
Journal Article
COVID-19 infections in infants
The study aimed to analyse the clinical course of COVID-19 in 300 infants, selected from 1283 children diagnosed with COVID-19 between March and December 2020, registered in the SARSTerPED multicenter database. Most of the infants were registered in October and November 2020. 44% of the group were girls, and 56% were boys. At diagnosis, the most common symptoms were fever in 77% of the children, cough in 40%, catarrh in 37%. Pneumonia associated with COVID-19 was diagnosed in 23% of the children, and gastrointestinal symptoms in 31.3%. In 52% of the infants, elevated levels of D-dimers were observed, and in 40%, elevated levels of IL-6 serum concentration were observed. During the second wave of the pandemic, 6 times more infants were hospitalized, and the children were statistically significantly younger compared to the patients during the first wave (3 months vs 8 months,
p
< 0.0001 respectively). During the second wave, the infants were hospitalized for longer. COVID-19 in infants usually manifests as a mild gastrointestinal or respiratory infection, but pneumonia is also observed with falls in oxygen saturation, requiring oxygen therapy. Gastrointestinal symptoms are common in infants infected with SARS-CoV-2, and infant appetite disorders may lead to hospitalization. The clinical course of the disease differed significantly between the first and second wave of the pandemic. It seems that infants may play a role in the transmission of SARS-COV-2 infections in households, despite mild or asymptomatic courses; eating disorders in infants should be an indication for COVID-19 testing.
Journal Article
The Impact of the COVID-19 Pandemic on the Epidemiology of Influenza in Hospitalised Children in the Years 2017–2025
Background: The COVID-19 pandemic significantly altered the circulation of respiratory viruses, including influenza. This study aimed to compare the epidemiology and clinical characteristics of paediatric influenza before, during, and after the pandemic. Methods: We retrospectively analysed 553 children aged 0–18 years hospitalised with laboratory-confirmed influenza at a paediatric infectious disease centre in Bydgoszcz, Poland, between September 2017 and August 2025. Patients were stratified into pre-pandemic (A), pandemic (B), and post-pandemic (C) periods. Epidemiological indicators, influenza type, age, sex, and hospital stay duration were assessed using χ2 and non-parametric tests. Results: Hospitalisations varied across seasons, lowest in 2021/22 (n = 18) and highest in 2024/25 (n = 175). Seasonal peaks occurred January–March in groups A and C, whereas group B showed a bimodal pattern in December and March–April. Influenza type A predominated in all periods, though less during the pandemic (56.7% vs. 89.2% pre-pandemic and 73.2% post-pandemic). Median hospital stay decreased from 5 days pre-pandemic to 4 days during and after the pandemic. None of the hospitalised children were vaccinated. Conclusions: The COVID-19 pandemic influenced influenza seasonality, virus type distribution, and hospitalisation patterns in children. Observed shifts highlight the importance of ongoing surveillance and targeted vaccination strategies to mitigate influenza burden in the post-pandemic period.
Journal Article
Catch and Cover Crops’ Use in the Energy Sector via Conversion into Biogas—Potential Benefits and Disadvantages
The development of civilization is related to an increase in energy demand, while its production is still based mainly on fossil fuels. The release of carbon into the environment, which disturbs the balance of the global system, is the consequence of using these fuels. One possible way to reduce the carbon footprint of the energy sector is the widespread use of cover crops’ biomass for energy production. The aim of this paper is to critically review the knowledge on the dissemination of catch and cover crops’ cultivation in different regions of the world, and the yield, chemical composition and biomethane potential of their biomass. Additionally, the environmental benefits, as well as the challenges and opportunities associated with this biomass use in the energy sector, are considered. The review showed that the aboveground biomass of cover and catch crops is a valuable source for the production of bioenergy in biogas plants. However, the key role of these crops is to prevent soil degradation. Therefore, changes in biomass target use must be preceded by a multi-aspect analysis that allows their impact on the environment to be assessed.
Journal Article
Efficiency of Chemical Pretreatment of Sugar Beet Pulp Biomass Intended to Energy Production via Biological Processes
Environmentally friendly anaerobic digestion (AD) of lignocellulose-based materials is becoming an increasingly popular alternative to non-renewable energy sources. It also corresponds with the principles of sustainable development. The structure of lignocellulosic materials, which is resistant to biodegradation, requires using pretreatment methods prior to subjecting them to anaerobic processes. The aim of the study was to evaluate the influence of temperature and type of hydrolyzing agent on the efficiency of chemical pretreatment of sugar beet pulp. Biomass samples soaked in distilled water and 0.05 M solutions of NaOH and H2SO4 were left for 20 h, both at room temperature (22 °C) and in a thermostated chamber (50 °C). The changes in pH, electrolytic conductivity (EC), concentration of volatile fatty acids (VFA), dissolved chemical oxygen demand (COD), and phenols were analyzed. The concentration of CODdissolved, demonstrating the efficiency of pretreatment methods, obtained after alkaline hydrolysis conducted at 22 °C was almost at the same level as in the case of acid hydrolysis carried out at 50 °C: 3451 mg dm−3 and 3608.5 mg dm−3, respectively. Hydrolysis carried out in a NaOH solution at 22 °C appears to be the most economical option for sugar beet pulp pretreatment out of all analyzed ones, as there is no need to increase expenditure on heating samples.
Journal Article