Journal Article

Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children

Pawłowska, Małgorzata, Smok, Beata, Domagalski, Krzysztof

2020

Overview

Purpose. The aim of this study was to evaluate the diagnostic and prognostic value of IL-6 and sTREM-1 in the course of SIRS and sepsis in children with reference to routinely used CRP and PCT. Methods. A prospective study included 180 patients at the ages from 2 months to 18 years hospitalized due to fever from November 2015 to January 2017. Forty-nine children without fever hospitalized due to noninfectious causes formed the control group. IL-6 and sTREM-1 serum concentrations were assessed with the enzyme-linked immunosorbent assay method. Results. The mean serum concentrations of all the analyzed biomarkers were statistically significantly higher in the study group compared to the control group. Mean IL-6, sTREM-1, and PCT serum concentrations were statistically significantly higher in the group of patients with SIRS/sepsis compared to the group of feverish patients without diagnosed SIRS (N-SIRS). Based on the ROC curve analysis, it was shown that of all the biomarkers tested, only two—IL-6 and procalcitonin—had potential usefulness in the diagnosis of SIRS/sepsis in children with fever. Conclusion. Elevated levels of IL-6 and PCT are important risk factors for the development of SIRS/sepsis in children with fever. It seems that elevated IL-6 baseline serum level may predict a more severe course of febrile illness in children, because based on the ROC curve analysis, it was found that IL-6 is a statistically significant prognostic marker of prolonged fever≥3 days and prolonged hospitalization>10 days. The assessment of the usefulness of sTREM-1 in the diagnosis of SIRS/sepsis in feverish children requires further research.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc,Hindawi Limited,Wiley
• Subject: Adolescent / Age / Bacterial infections / Biomarkers / Biomarkers - blood / Calcitonin - blood / Child / Child, Preschool / Children / Critical care / Cytokines / Diagnosis / Disease / Diseases / Enzyme-linked immunosorbent assay / Enzymes / Female / Fever / Fluids / Hospitalization / Humans / Hyperthermia / Infant / Infection / Infections / Inflammation / Inflammatory diseases / Interleukin 6 / Interleukin-6 - blood / Male / Medical research / Medicine, Experimental / Neutrophils / Pediatric diseases / Pediatrics / Procalcitonin / Prognosis / Prospective Studies / Proteins / Researchers / Risk factors / Sepsis / Sepsis - blood / Sepsis - pathology / Statistical analysis / Systemic Inflammatory Response Syndrome - blood / Systemic Inflammatory Response Syndrome - diagnosis / Systemic Inflammatory Response Syndrome - pathology / Triggering Receptor Expressed on Myeloid Cells-1 - blood / Variance analysis