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This study evaluates Salmonella contamination in feed mill production facilities over a 12-year period, analyzing collection events from 12 facilities predominantly located in the southeastern United States. The genomic data reveals a historical contamination rate, with 20% of collection events testing positive for Salmonella . Utilizing next generation sequencing this study evaluated the genetic diversity in the different facilities to determine whether the Salmonella serovars that were found are transient or resident. Salmonella serovars Montevideo, Ruiru, and Senftenberg were frequently detected, with Ruiru showing a particularly high predominance across multiple facilities, suggesting possible common sources of contamination including regional fishing waters and shared additives. The study also highlights the role of transportation and storage methods as a possible cause of cross-contamination. Future research should focus on identifying specific contamination sources and optimizing control measures to reduce Salmonella risks in fish meal production.

Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract disease in young children and older adults. We designed a codon-optimized mRNA vaccine, mRNA-1345, encoding the RSV F-glycoprotein stabilized in the prefusion (preF) conformation and with a deletion at the cytoplasmic tail. mRNA-1345 cell surface protein expression was higher and detected for longer versus previous mRNA-based RSV vaccine candidates evaluated clinically. In rodent models, mRNA-1345 induced a robust neutralizing and preF-biased antibody response, a T helper 1–biased cellular response, and demonstrated dose-dependent protection against RSV challenge with no evidence of enhanced respiratory disease. These results supported initial clinical evaluation of mRNA-1345 in adults, children, and RSV-naïve infants; mRNA-1345 was recently demonstrated to be efficacious against RSV disease in older adults in a pivotal efficacy study.