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"Ren, Peng"
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Updates on Plant-Based Protein Products as an Alternative to Animal Protein: Technology, Properties, and Their Health Benefits
Plant-based protein products, represented by “plant meat”, are gaining more and more popularity as an alternative to animal proteins. In the present review, we aimed to update the current status of research and industrial growth of plant-based protein products, including plant-based meat, plant-based eggs, plant-based dairy products, and plant-based protein emulsion foods. Moreover, the common processing technology of plant-based protein products and its principles, as well as the emerging strategies, are given equal importance. The knowledge gap between the use of plant proteins and animal proteins is also described, such as poor functional properties, insufficient texture, low protein biomass, allergens, and off-flavors, etc. Furthermore, the nutritional and health benefits of plant-based protein products are highlighted. Lately, researchers are committed to exploring novel plant protein resources and high-quality proteins with enhanced properties through the latest scientific and technological interventions, including physical, chemical, enzyme, fermentation, germination, and protein interaction technology.
Journal Article
Transport and public health in China: the road to a healthy future
Transportation-related risk factors are a major source of morbidity and mortality in China, where the expansion of road networks and surges in personal vehicle ownership are having profound effects on public health. Road traffic injuries and fatalities have increased alongside increased use of motorised transport in China, and accident injury risk is aggravated by inadequate emergency response systems and trauma care. National air quality standards and emission control technologies are having a positive effect on air quality, but persistent air pollution is increasingly attributable to a growing and outdated vehicle fleet and to famously congested roads. Urban design favours motorised transport, and physical activity and its associated health benefits are hindered by poor urban infrastructure. Transport emissions of greenhouse gases contribute substantially to regional and global climate change, which compound public health risks from multiple factors. Despite these complex challenges, technological advances and innovations in planning and policy stand to make China a leader in sustainable, healthy transportation.
Journal Article
Novel insights into ferroptosis: Implications for age-related diseases
Rapid increase in aging populations is an urgent problem because older adults are more likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare systems and society in general. ARDs are characterized by the progressive deterioration of tissues and organs over time, eventually leading to tissue and organ failure. To date, there are no effective interventions to prevent the progression of ARDs. Hence, there is an urgent need for new treatment strategies. Ferroptosis, an iron-dependent cell death, is linked to normal development and homeostasis. Accumulating evidence, however, has highlighted crucial roles for ferroptosis in ARDs, including neurodegenerative and cardiovascular diseases. In this review, we a) summarize initiation, regulatory mechanisms, and molecular signaling pathways involved in ferroptosis, b) discuss the direct and indirect involvement of the activation and/or inhibition of ferroptosis in the pathogenesis of some important diseases, and c) highlight therapeutic targets relevant for ARDs.
Journal Article
The impacts of built environment on ridesourcing demand
Recently, the explosive growth of ridesourcing, or on-demand ridesharing, has attracted a great deal of attention from researchers and planners. Despite its transformative impacts on mobility, limited studies have examined how built environment affects its use. In this study, we investigate the impacts of built environment on ridesourcing demand. We employ structural equation modelling to account for the complex relationships among study variables, and investigate the impacts at census block group level by using RideAustin data in Austin, Texas. Findings reveal strong impacts of built environment on ridesourcing demand and significant temporal heterogeneity. The models show that greater population/employment/service job densities, road density, pavement completeness, land use mix and job accessibility by transit produce more ridesourcing demand. Access to the commuter rail (MetroRail) also leads to greater demand. Furthermore, time-of-day (TOD) models demonstrate that these effects vary significantly according to the time of day. Our research has implications for policy making and for travel demand modelling of ridesourcing.
最近，网约车或按需共享出行的爆炸性增长引起了研究人员和规划人员的极大关注。尽管它对出行产生了变革性影响，但人们很少研究建筑环境对其使用的影响。在本研究中，我们研究了建筑环境对网约车需求的影响。我们采用结构方程模型来解释研究变量之间的复杂关系，并使用德克萨斯州奥斯汀市的RideAustin数据来研究人口普查区块组层面的影响。研究结果显示了建筑环境对网约车需求的强烈影响，以及显著的时间异质性。模型显示，人口/就业/服务工作密度、道路密度、路网完整性、土地使用组合完备性、以及通过公交的工作可达性越高，网约车需求就越高。接近通勤铁路（MetroRail）也会带来更多的需求。此外，日内时段（TOD）模型表明，这些影响在一天中的不同时段显著不同。我们的研究对于政策制定和网约车出行需求建模具有重要意义。
Journal Article
A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice
Synthetic biology has advanced the design of genetic devices that can be used to reprogram metabolic activities in mammalian cells. By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice. In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination. Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice. Synthetic light-pulse—transcription converters may have applications in therapeutics and protein expression technology.
Journal Article
Highly compressible polyimide/graphene aerogel for efficient oil/water separation
Graphene aerogel with three-dimensional (3D) interconnected porous structure and good hydrophobicity has been extensively investigated for sorbent materials for oils and demonstrated to be effective. Herein, a 3D polyimide–graphene aerogel (PI-GA) nanocomposite has been prepared by introducing water-soluble polyimide (PI). Benefiting from the synergetic effect of PI and GA, the PI-GA nanocomposite exhibits ultralow density, excellent compressibility and hydrophobicity. When evaluated as a sorbent material for oils and organic solvent, PI-GA nanocomposite has high absorption capacity and can separate oil from water rapidly and efficiently. Furthermore, the mechanical squeezing process can be used for the recycling of the PI-GA due to its excellent compressibility. The excellent absorption performance and robust mechanical properties make the PI-GA suitable for oil cleanup and chemical leakage.
Journal Article
The role of lattice dynamics in ferroelectric switching
Reducing the switching energy of ferroelectric thin films remains an important goal in the pursuit of ultralow-power ferroelectric memory and logic devices. Here, we elucidate the fundamental role of lattice dynamics in ferroelectric switching by studying both freestanding bismuth ferrite (BiFeO
3
) membranes and films clamped to a substrate. We observe a distinct evolution of the ferroelectric domain pattern, from striped, 71° ferroelastic domains (spacing of ~100 nm) in clamped BiFeO
3
films, to large (10’s of micrometers) 180° domains in freestanding films. By removing the constraints imposed by mechanical clamping from the substrate, we can realize a ~40% reduction of the switching voltage and a consequent ~60% improvement in the switching speed. Our findings highlight the importance of a dynamic clamping process occurring during switching, which impacts strain, ferroelectric, and ferrodistortive order parameters and plays a critical role in setting the energetics and dynamics of ferroelectric switching.
Reducing the switching energy of ferroelectric films remains an important goal. Here, the authors elucidate the fundamental role of lattice dynamics in ferroelectric switching on both freestanding BiFeO
3
membranes and films clamped to a substrate.
Journal Article
An agent-based model for community flood adaptation under uncertain sea-level rise
Adaptation has become the major approach to reduce the adverse effects of storm surge and sea-level rise. However, maladaptation can happen when adaptation actions unintentionally increase community vulnerability. To evaluate the adequacy and efficacy of adaptation policies under uncertain sea-level rise, this study presents an agent-based model by integrating the random nature of storm surges, private adaptation decisions, and real estate market valuation. We evaluated the evolving flood damage of different adaptation strategies under two bounding cases of real estate market change. Our model results quantitatively illustrate the accelerating damages of storm surges under climate-induced sea-level rise. A reform in flood insurance to risk-based rates with a means-tested voucher program and a government-subsidized “twice and out” buyout program could both substantially improve coastal resilience. However, community adaptation with a public seawall may deliver false risk perception to high-risk property owners and result in maladaptation when sea-level rise rate is high. The modeling approach developed in this study can be used as a policy analysis tool to measure the impacts of sea-level rise and the effectiveness of adaptation strategies in coastal communities.
Journal Article
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acute phase response and inflammatory response. In our current study, transcriptomics analysis, proteomics analysis, and Western blotting showed that the expression level of Serpin clade A member 3N (SerpinA3N) is significantly increased in the hippocampus of mice with kainic acid (KA)-induced temporal lobe epilepsy, and this molecule is mainly expressed in astrocytes. Notably, in vivo studies using gain- and loss-of-function approaches revealed that SerpinA3N in astrocytes promoted the release of proinflammatory factors and aggravated seizures. Mechanistically, RNA sequencing and Western blotting showed that SerpinA3N promoted KA-induced neuroinflammation by activating the NF-κB signaling pathway. In addition, co-immunoprecipitation revealed that SerpinA3N interacts with ryanodine receptor type 2 (RYR2) and promotes RYR2 phosphorylation. Overall, our study reveals a novel SerpinA3N-mediated mechanism in seizure-induced neuroinflammation and provides a new target for developing neuroinflammation-based strategies to reduce seizure-induced brain injury.
Journal Article