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A simple and novel route for the synthesis of new terphenyl derivative as well as oxidative aromatization of α,β-unsaturated cyclohexenone to the corresponding phenol derivative is developed. The present work involves the condensation of ethylacetoacetate with 4,4'-difluoro chalcone followed by the aromatization using chloramine-T in acetic acid to yield the title compound (3). The synthesized compound (3) is well characterized by IR, NMR, LCMS and elemental analysis.

Two new pyrazoline derivatives, 3,5-bis(4-fluorophenyl)-4,5-dihydropyrazole-1-carboxamide (1) and 3,5-bis(4-fluorophenyl)-4,5-dihydropyrazole-1-carbothioamide (2), were synthesized by reacting 4,4'-difluoro chalcone with semicarbazide hydrochloride and thiosemicarbazide in ethanolic sodium hydroxide solution. Both the compounds were confirmed by single crystal X-ray diffraction data and supported by IR, NMR, and mass spectral data. In 1, crystal packing is stabilized by N–H…O hydrogen bonds and weak N–H...N, N–H…F and C–H…F intermolecular interactions. In 2, only weak N–H…F and N–H…S intermolecular interactions are observed. Crystal data: C16H13F2N3O, (1), Mr = 301.29, monoclinic, C2/c, a = 17.6219(6) Å, b = 10.8735(3) Å, c = 15.3216(5) Å, β = 102.864(3)°, V = 2862.11(16) Å3, Z = 8, T = 173 K, R(F) = 0.0511, wR(F2) = 0.1333; C16H13F2N3S, (2), Mr = 317.35, monoclinic, P21/c, a = 14.339(2) Å, b = 11.1478(17) Å, c = 9.541(2)(5) Å, β = 107.007(18)°, V = 1458.5(5) Å3, Z = 4, T = 173 K, R(F) = 0.0413, wR(F2) = 0.0959.

A new spiro[indole-3,3'-pyrrolizine] derivative is regioselectively synthesized by the straightforward multicomponent reaction of 1-(4-fluorophenyl)-3-phenylprop-2-en-1-one, isatin and L-proline without any catalyst. The structure of the newly synthesized compound is characterized by IR, NMR, UV-visible and mass spectral data. The compound is also screened for its reducing power assay.

A simple and novel route for synthesis of new spirocyclic compound is developed. The present work involves condensation of ethyl nipecotate with 2-furaldehyde followed by the MnO2 oxidation to give the β-keto ester which upon reaction with hydrazine hydrate gives the spiro pyrazolone.

A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (3).

A novel route for the synthesis of new spirocyclic derivative is developed. The present work involves the synthesis of title compound 3 by Suzuki coupling of 3,5-difluorophenyl boronic acid with tert-butyl 1-(5-bromofuran-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate (2), which in turn prepared from the ethyl nipecotate (1). Newly prepared spirocyclic derivative (3) is characterized by IR, NMR and mass spectral data.

S-Alkylation of 5-(diphenylmethyl)-1,3,4-oxadiazole-2(3H)-thione (3) by 2-chloro-N-(pyrazin-2-yl)acetamide (2) affords the title compound, 2-{[5-(diphenylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(pyrazin-2-yl)acetamide (4). The intermediate (2), in turn, was prepared by the acetylation of 2-aminopyrazine (1) with chloroacetyl chloride. The structure of the newly synthesized compound is characterized by IR, NMR and mass spectral data.

A simple and novel route for synthesis of new spirocyclic amide derivative is developed. The present work involves the oxidative cleavage of tert-butyl 1-(furan-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate 1 followed by the amine coupling and deprotection of Boc.

Novel terphenyl chalcone containing benzimidazole moiety (3) is synthesized by the base-catalyzed Claisen–Schmidt condensation of acetyl terphenyl derivative (1) with 4-(1H-benzimidazol-2-ylmethoxy)-3-methoxybenzaldehyde (2). Newly prepared chalcone derivative (3) is characterized by IR, NMR and mass spectral data.

Steel is the most important engineering and construction material in the world. Corrosion problems have received a considerable amount of attention because of their attack on materials. Corrosion not only has economic implications, but also social and these engage the safety and health of people either working in industries or living in nearby towns. The use of inhibitors is one of the most practical methods for protection against corrosion. Organic compounds are investigated as corrosion inhibitors, but unfortunately most of these compounds are not only expensive but also toxic to living beings. Fatty acids extracted from plants have become an environmentally acceptable, readily available and renewable source for inhibitors. Many corrosion inhibitor molecules were synthesized by derivatization of fatty acids which was extracted from vegetable oils. Review of literature indicated that the derivatives of fatty acids like ethyl ester, ethoxylate, sulfate, imidazoline, sulfate-amine salt, hydrazides, thiosemicarbazides, phenyl hydrazides, triazoles, oxadiazoles,phenyl thiosemicarbazide etc. were the effective corrosion inhibitors for mild steel in aggressive media.