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On January 29, 2020, a total of 195 US citizens were evacuated from the coronavirus disease 2019 (COVID-19) epidemic in Wuhan, China, to March Air Reserve Base in Riverside, California, and entered the first federally mandated quarantine in over 50 years. With less than 1-d notice, a multi-disciplinary team from Riverside County and Riverside University Health System in conjunction with local and federal agencies established on-site 24-h medical care and behavioral health support. This report details the coordinated efforts by multiple teams that took place to provide care for the passengers and to support the surrounding community.

To determine prevalence of, seroprevalence of, and potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a cohort of evacuees returning to the United States from Wuhan, China, in January 2020, we conducted a cross-sectional study of quarantined evacuees from 1 repatriation flight. Overall, 193 of 195 evacuees completed exposure surveys and submitted upper respiratory or serum specimens or both at arrival in the United States. Nearly all evacuees had taken preventive measures to limit potential exposure while in Wuhan, and none had detectable SARS-CoV-2 in upper respiratory tract specimens, suggesting the absence of asymptomatic respiratory shedding among this group at the time of testing. Evidence of antibodies to SARS-CoV-2 was detected in 1 evacuee, who reported experiencing no symptoms or high-risk exposures in the previous 2 months. These findings demonstrated that this group of evacuees posed a low risk of introducing SARS-CoV-2 to the United States.

In summary Lawmakers and the governor must look ahead and plan for a public health system that is not just adequate, but second to none.

In this study, we investigated the morphology transition of polyion complex (PIC) micelles with the change in block ratio and pH-responsivity of PIC micelles or vesicles using entirely ionic diblock copolymers composed of carboxybetaine and ionic blocks. We used 2-((2-(methacryloylo-xy)ethyl)dimethylammonio)acetate (PGLBT) as carboxybetaine, poly(sodium styrenesulfonate) (PSSNa) as the anionic polymer, and poly[3-(methacrylamido)propyltrimethylammonium chlorid-e] (PMAPTAC) as the cationic polymer. The effect of pH on the PGLBT homopolymer and the PGLBT-containing diblock copolymer was examined by DLS, ELS, and transmittance, and a rapid change of state was observed between pH 4 and 2. At this pH, the carboxyl group of PGLBT was protonated to form a hydrogen bond in the molecule. Furthermore, at a lower pH, diblock copolymer behaved like a cationic polymer. The formation behavior of PIC micelles at different block ratios in the diblock copolymers was investigated by DLS, SLS, TEM, and AFM. PIC vesicles formed when the block ratio of ionic blocks to the PGLBT block was equal or larger (the content of PGLBT was 52% or less). On the other hand, PIC micelles were formed when the block ratio of PGLBT to ionic blocks was larger (the content of PGLBT was 68% or more). The pH-responsivity of PIC micelles was different from that of PIC vesicles. The size of PIC vesicles decreased by lowering pH and increased when the below pH 3. The behavior was the same as the change of state of PGLBT homopolymer with the change in pH. However, the size of PIC micelles increased by lowering pH from pH 6 to 3 and decreased at pH below pH 3. The PGLBT, which became the shell, changed its state with the change in pH and affected the aggregation number of micelles.