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One of the most important challenges for soil science is to determine the limits for the sustainable functioning of contaminated ecosystems. The response of soil microbiomes to kerosene pollution is still poorly understood. Here, we model the impact of kerosene leakage on the composition of the topsoil microbiome in pot and field experiments with different loads of added kerosene (loads up to 100 g/kg; retention time up to 360 days). At four time points we measured kerosene concentration and sequenced variable regions of 16S ribosomal RNA in the microbial communities. Mainly alkaline Dystric Arenosols with low content of available phosphorus and soil organic matter had an increased fraction of Actinobacteriota, Firmicutes, Nitrospirota, Planctomycetota, and, to a lesser extent, Acidobacteriota and Verrucomicobacteriota. In contrast, in highly acidic Fibric Histosols, rich in soil organic matter and available phosphorus, the fraction of Acidobacteriota was higher, while the fraction of Actinobacteriota was lower. Albic Luvisols occupied an intermediate position in terms of both physicochemical properties and microbiome composition. The microbiomes of different soils show similar response to equal kerosene loads. In highly contaminated soils, the proportion of anaerobic bacteria-metabolizing hydrocarbons increased, whereas the proportion of aerobic bacteria decreased. During the field experiment, the soil microbiome recovered much faster than in the pot experiments, possibly due to migration of microorganisms from the polluted area. The microbial community of Fibric Histosols recovered in 6 months after kerosene had been loaded, while microbiomes of Dystric Arenosols and Albic Luvisols did not restore even after a year.

Fires in the ecosystems of Central Kazakhstan trigger a pyrogenic succession for 1-2 decades as usual. In recent years, changes of climate and land use in region have led to the intensification of fires and the gradual steppification of the territory, where desert vegetation was previously successfully restored. We analyzed the change in aboveground phytomass stocks during 40 years of pyrogenic succession. In the zonal communities, the phytomass reaches the background values in eight years after the fire and does not change later. For intrazonal communities in river valleys and gullies, aboveground phytomass stocks at the 4 th and 16 th years of succession do not differ significantly, and the structure of phytomass fractions by the 16 th year resembles background zonal communities. This can be associated with a more intense grazing on the intrazonal communities in river valleys and gullies in the studied region.

Significant environmental impacts of mining activities connected with high-sulfur materials result from the production of acid mine drainage and potentially toxic elements, which easily migrate to adjacent ecosystems due to the typical absence of vegetation on spoil heaps and toeslope talus mantle. In this paper, we present the results of the first comprehensive study of the ecosystems affected by acidic and metal-enriched (Al, Ca, Co, Cu, Fe, Mg, Mn, Ni, and Zn) mine drainage conducted at spoil heaps and adjacent talus mantle under semihumid climate conditions within the Moscow Brown Coal Basin (Central Russian Upland, Tula Region, Russia). A total of 162 samples were collected, including 98 soil samples, 42 surface water samples, and 22 plant samples (aerial tissues of birch). Coal talus mantle materials of Regosols were characterized by the increased concentration of water-soluble Ca, K, Mg, and S, and all mobile fractions of Al, Co, S, and Zn. The chemical composition of birch samples within the zones affected by acid mine drainage differed insignificantly from those in the unpolluted ecosystems with black soils, due to the high tolerance of birch to such conditions. Differences between the affected and undisturbed sites in terms of the chemical composition decreased in the following order: waters > soils > plants. The geochemical characterization of plants and soils in coal mining areas is essential for the mitigation of negative consequences of mining activities.

The dynamics of species richness and diversity indices in pyrogenic successions of sagebrush and perennial saltwort communities in Central Kazakhstan were analyzed. The biodiversity of such communities during the initial years after fires was higher than that in unburnt phytocenoses. However, values of biodiversity parameters significantly decreased 27-31 years after fires.

Understanding the rate and direction of pyrogenic succession in arid ecosystems, which depends on many factors, including the intensity of grazing and the frequency of pyrogenic expo-sure, will allow for more accurate predictions of the consequences of fire onplant communities, and will assist with better fire management. We studied the vegetation on 55 sites in and near the “Chernye Zemli” Natural Biosphere Reserve that burned at different times or were not affected by fires over the past 35 years and characterized the changes in vegetation cover associated with the impact of wildfire and grazing. The descriptions were grouped into chronological stages according to the time elapsed since the last fire, or into groups according to the frequency of fires. In pairwise comparison of the projective cover of plant species between chronological stages, it correlated most strongly between successive initial stages (for stages 1 and 2, p = 0.003, r = 0.73; for stages 2 and 3, p < 0.001, r = 0.78). Species with an initially higher projective cover were more likely to grow on plots in the first year after the fire: p < 0.03. Plots with rare and frequent fires had similar projective cover of individual species (r = 0.64, p < 0.001). We conclude that in the course of pyrogenic succession, communities are gradually replaced over at least ten years. At the same time, the composition of a plant community at the initial point of succession depends on the prevalence of species in the community before the fire. No fundamental effect of the frequency of fires on the composition of plant communities has been revealed.

Dust particles from high latitudes have a potentially large local, regional, and global significance to climate and the environment as short-lived climate forcers, air pollutants, and nutrient sources. Identifying the locations of local dust sources and their emission, transport, and deposition processes is important for understanding the multiple impacts of high-latitude dust (HLD) on the Earth’s systems. Here, we identify, describe, and quantify the source intensity (SI) values, which show the potential of soil surfaces for dust emission scaled to values 0 to 1 concerning globally best productive sources, using the Global Sand and Dust Storms Source Base Map (G-SDS-SBM). This includes 64 HLD sources in our collection for the northern (Alaska, Canada, Denmark, Greenland, Iceland, Svalbard, Sweden, and Russia) and southern (Antarctica and Patagonia) high latitudes. Activity from most of these HLD sources shows seasonal character. It is estimated that high-latitude land areas with higher (SI ≥ 0.5), very high (SI ≥ 0.7), and the highest potential (SI ≥ 0.9) for dust emission cover > 1 670 000 km2 , > 560 000 km2 , and > 240 000 km2 , respectively. In the Arctic HLD region (≥ 60◦ N), land area with SI ≥ 0.5 is 5.5 % (1 035 059 km2), area with SI ≥ 0.7 is 2.3 % (440 804 km2), and area with SI ≥ 0.9 is 1.1 % (208 701 km2). Minimum SI values in the northern HLD region are about 3 orders of magnitude smaller, indicating that the dust sources of this region greatly depend on weather conditions. Our spatial dust source distribution analysis modeling results showed evidence supporting a northern HLD belt, defined as the area north of 50◦ N, with a “transitional HLD-source area” extending at latitudes 50–58◦ N in Eurasia and 50–55◦ N in Canada and a “cold HLD-source area” including areas north of 60◦ N in Eurasia and north of 58◦ N in Canada, with currently “no dust source” area between the HLD and low-latitude dust (LLD) dust belt, except for British Columbia. Using the global atmospheric transport model SILAM, we estimated that 1.0 % of the global dust emission originated from the high-latitude regions. About 57 % of the dust deposition in snow- and ice-covered Arctic regions was from HLD sources. In the southern HLD region, soil surface conditions are favorable for dust emission during the whole year. Climate change can cause a decrease in the duration of snow cover, retreat of glaciers, and an increase in drought, heatwave intensity, and frequency, leading to the increasing frequency of topsoil conditions favorable for dust emission, which increases the probability of dust storms. Our study provides a step forward to improve the representation of HLD in models and to monitor, quantify, and assess the environmental and climate significance of HLD.

PurposeIn sulfur coal mining areas, soils are impacted by acid mine drainage and solid-phase mine wastes containing sulfides and carbonaceous particles. Formation of new landforms leads to alteration of soil hydrological regime. The aim of the study was to examine the evolution of morphological and chemical properties of chernozems under the impact of supply of technogenic material from the spoil heaps and changes of the terrain in abandoned sulfur coal mining areas.Materials and methodsWe examined waste dumps and acid mine drainage (AMD) released from two abandoned spoil heaps in the Tula Region (Russian Federation) and soils on the adjacent territories. Sampling and description of soil morphology were performed twice for each site with an interval of 10 years. Composition and content of salts in soils and waste dumps, exchangeable cations and organic carbon in soils, mineralization of AMD, and some other chemical properties were determined.Results and discussionTechnogenically transformed chernozems with complex morphological structure and specific chemical properties of soil profile were formed. The content of readily soluble salts exceeded 1% compared with < 0.1% in natural chernozems. Concentrations and ratio of Ca2+ and Mg2+ in soil horizons changed. The amount of extractable acidity was up to 17.5 cmolc kg−1. Concentrations of organic carbon exceeded background values by 1.2–2.6 times.ConclusionsLong-term supply of sulfide-containing technogenic material to the environment led to significant geochemical transformation of chernozems. Morphological and chemical properties of the post-technogenic soils in the vicinity of spoil heaps have no analogues in natural forest-steppe landscapes of the Russian Plain.

Rocket launches are a source of anthropogenic disturbance to Central Kazakhstan ecosystems. Multistage launch vehicles (LV) are used for orbit insertion of different spacecrafts from the Baikonur cosmodrome (Republic of Kazakhstan). The launch consists of stages during which the rocket separates successively, with pieces falling to the ground along the flight route of the LV. Regions of first stage falling located in Central Kazakhstan endure the most intensive impact. First stage fallings lead to mechanical and pyrogenic disturbance and pollution by fuel components. We characterized vegetation changes at the first stage falling sites of ‘Proton-M’ rocket carriers during two growing seasons. Spontaneous revegetation by ruderal plant communities occurs after falling. First stage falling sites have lower vegetation cover and species diversity. Ceratocarpus arenarius is a dominant species in plant communities at the sites that have been affected by first stage falling. After winter rocket launches vegetation is less deteriorated at the falling sites than after spring and summer launches. The recovery process in plant communities is considerably faster at falling sites corresponding to winter rocket launches. Nomenclature: S.K. Cherepanov (1995).

Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in (APDS1) or (APDS2), is a heterogeneous primary immunodeficiency. While initial cohort-descriptions summarized the spectrum of clinical and immunological manifestations, questions about long-term disease evolution and response to therapy remain. The prospective European Society for Immunodeficiencies (ESID)-APDS registry aims to characterize the disease course, identify outcome predictors, and evaluate treatment responses. So far, 77 patients have been recruited (51 APDS1, 26 APDS2). Analysis of disease evolution in the first 68 patients pinpoints the early occurrence of recurrent respiratory infections followed by chronic lymphoproliferation, gastrointestinal manifestations, and cytopenias. Although most manifestations occur by age 15, adult-onset and asymptomatic courses were documented. Bronchiectasis was observed in 24/40 APDS1 patients who received a CT-scan compared with 4/15 APDS2 patients. By age 20, half of the patients had received at least one immunosuppressant, but 2-3 lines of immunosuppressive therapy were not unusual before age 10. Response to rapamycin was rated by physician visual analog scale as good in 10, moderate in 9, and poor in 7. Lymphoproliferation showed the best response (8 complete, 11 partial, 6 no remission), while bowel inflammation (3 complete, 3 partial, 9 no remission) and cytopenia (3 complete, 2 partial, 9 no remission) responded less well. Hence, non-lymphoproliferative manifestations should be a key target for novel therapies. This report from the ESID-APDS registry provides comprehensive baseline documentation for a growing cohort that will be followed prospectively to establish prognostic factors and identify patients for treatment studies.

The extent of mitochondrial heterogeneity and the presence of mitochondrial archetypes in cancer remain unknown. Mitochondria play a central role in the metabolic reprogramming that occurs in cancer cells. This process adjusts the activity of metabolic pathways to support growth, proliferation, and survival of cancer cells. Using a panel of colorectal cancer (CRC) cell lines, we revealed extensive differences in their mitochondrial composition, suggesting functional specialisation of these organelles. We differentiated bioenergetic and mitochondrial phenotypes, which point to different strategies used by CRC cells to maintain their sustainability. Moreover, the efficacy of various treatments targeting metabolic pathways was dependent on the respiration and glycolysis levels of cancer cells. Furthermore, we identified metabolites associated with both bioenergetic profiles and cell responses to treatments. The levels of these molecules can be used to predict the therapeutic efficacy of anti-cancer drugs and identify metabolic vulnerabilities of CRC. Our study indicates that the efficacy of CRC therapies is closely linked to mitochondrial status and cellular bioenergetics.