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This study investigates the influence of vertical separation between the girder and bearings under bidirectional seismic excitations on the failure modes of shear keys. A continuum dynamic model for a two-span girder bridge was established and solved using the transient wave eigenfunction expansion method. The dynamic response of structural vertical separation and horizontal collision under bidirectional seismic excitations was systematically analyzed. The results indicate that the vertical seismic component induces separation at the girder–bearing interface, which significantly alters both the magnitude and contact location of the horizontal collision force on the shear keys. This phenomenon is most pronounced when the predominant period of the ground motion approaches the structure’s vertical natural period, drastically amplifying the girder’s horizontal seismic response. Consequently, the failure mode of shear keys exhibits an evolutionary sequence: with increasing seismic amplitude, it transitions from flat shear to inclined shear, and ultimately to flexural failure. Crucially, this dynamic coupling effect simultaneously amplifies the horizontal collision force and reduces the shear keys’ load-bearing capacity. Under the most unfavorable collision conditions, the limit of the horizontal collision force can reach up to 5.12 times greater than its design bearing capacity. This study reveals that neglecting vertical seismic excitation severely underestimates the actual failure risk of shear keys, underscoring the critical need to consider this coupling effect in the seismic design and performance evaluation of bridges in high-intensity zones.

Background Tribenuron methyl (TBM) is an herbicide that inhibits sulfonylurea acetolactate synthase (ALS) and is one of the most widely used broad-leaved herbicides for crop production. However, soil residues or drifting of the herbicide spray might affect the germination and growth of rapeseed, Brassica napus , so it is imperative to understand the response mechanism of rape to TBM during germination. The aim of this study was to use transcriptome analysis to reveal the gene responses in herbicide-tolerant rapeseed to TBM stress during seed germination. Results 2414, 2286, and 1068 differentially expressed genes (DEGs) were identified in TBM-treated resistant vs sensitive lines, treated vs. control sensitive lines, treated vs. control resistant lines, respectively. GO analysis showed that most DEGs were annotated to the oxidation-reduction pathways and catalytic activity. KEGG enrichment was mainly involved in plant-pathogen interactions, α-linolenic acid metabolism, glucosinolate biosynthesis, and phenylpropanoid biosynthesis. Based on GO and KEGG enrichment, a total of 137 target genes were identified, including genes involved in biotransferase activity, response to antioxidant stress and lipid metabolism. Biotransferase genes, CYP450, ABC and GST , detoxify herbicide molecules through physical or biochemical processes. Antioxidant genes, RBOH, WRKY, CDPK, MAPK, CAT, and POD regulate plant tolerance by transmitting ROS signals and triggering antioxidant enzyme expression. Lipid-related genes and hormone-related genes were also found, such as LOX3, ADH1, JAZ6, BIN2 and ERF , and they also played an important role in herbicide resistance. Conclusions This study provides insights for selecting TBM-tolerant rapeseed germplasm and exploring the molecular mechanism of TBM tolerance during germination.

Coastal continuous girder bridges are exposed to coupled environmental and seismic hazards during long-term service, including chloride-induced corrosion, freeze–thaw damage, scour, near-field ground motions, and structural irregularity. These factors can progressively reduce structural capacity, amplify seismic demand, redistribute component responses, and affect post-earthquake functionality and recovery. This paper reviews recent advances in the time-dependent seismic vulnerability and resilience assessment of reinforced concrete and prestressed concrete coastal continuous girder bridges. Based on 229 screened publications, the review first summarizes deterioration mechanisms and modelling approaches for chloride corrosion, freeze–thaw damage, and scour, with emphasis on their effects on material degradation, component capacity, foundation restraint, and seismic fragility. The demand-side effects of near-field vertical excitation and pulse-like ground motions are then discussed, followed by the seismic response characteristics of irregular continuous girder bridges, including curved alignments, unequal pier heights, and skewed supports. Existing studies indicate that environmental deterioration can shift fragility curves toward lower intensity levels, near-field vertical excitation can modify axial force, bearing contact state, girder–bearing separation, and impact response, while structural irregularity may concentrate seismic demand in critical components. Furthermore, the review clarifies the transition from time-dependent fragility analysis to functionality loss, recovery modelling, and lifecycle resilience assessment. The main research gaps include simplified deterioration representation, insufficient coupling of deterioration–hazard–irregularity effects, limited validation of time-dependent fragility models, and weak integration between component damage, bridge functionality, recovery trajectories, and resilience indicators. Future studies should develop more unified, uncertainty-informed, and lifecycle-oriented frameworks for coastal bridge vulnerability and resilience assessment.

Key MessageBy integrating QTL mapping, transcriptomics and metabolomics, 138 hub genes were identified in rapeseed root response to aluminum stress and mainly involved in metabolism of lipids, carbohydrates and secondary metabolites.Aluminum (Al) toxicity has become one of the important abiotic stress factors in areas with acid soil, which hinders the absorption of water and nutrients by roots, and consequently retards the growth of crops. A deeper understanding of the stress-response mechanism of Brassica napus may allow us to identify the tolerance gene(s) and use this information in breeding-resistant crop varieties. In this study, a population of 138 recombinant inbred lines (RILs) was subjected to aluminum stress, and QTL (quantitative trait locus) mapping was used to preliminarily locate quantitative trait loci related to aluminum stress. Root tissues from seedlings of an aluminum-resistant (R) line and an aluminum-sensitive (S) line from the RIL population were harvested for transcriptome sequencing and metabolome determination. By combining the data on quantitative trait genes (QTGs), differentially expressed genes (DEGs), and differentially accumulated metabolites (DAMs), key candidate genes related to aluminum tolerance in rapeseed were determined. The results showed that there were 3186 QTGs in the RIL population, 14,232 DEGs and 457 DAMs in the comparison between R and S lines. Lastly, 138 hub genes were selected to have a strong positive or negative correlation with 30 important metabolites (|R|≥ 0.95). These genes were mainly involved in the metabolism of lipids, carbohydrates and secondary metabolites in response to Al toxicity stress. In summary, this study provides an effective method for screening key genes by combining QTLs, transcriptome sequencing and metabolomic analysis, but also lists key genes for exploring the molecular mechanism of Al tolerance in rapeseed seedling roots.

In this paper, we first show a DDH Lemma, which states that a multi-variable version of the decisional Diffie–Hellman problem is hard under the standard DDH assumption, where the group size is not necessarily known. Our proof, based on a self-reducibility technique, has a small reduction complexity. Using DDH Lemma, we extend the FSS pseudorandom generator of Farashahi et al. to a new one. The new generator is almost twice faster than FSS while still provably secure under the DDH assumption. Using the similar technique for the RSA modulus, we improve the Goldreich–Rosen generator. The new generator is provably secure under the factoring assumption and DDH assumption over \\(Z_N^*\\). Evidently, to achieve the same security level, different generators may have different security parameters (e.g., distinct length of modulus). We compare our generators with other generators under the same security level. For simplicity, we make comparisons without any pre-computation. As a result, our first generator is the most efficient among all generators that are provably secure under standard assumptions. It has the similar efficiency as Gennaro generator, where the latter is proven secure under a non-standard assumption. Our second generator is more efficient than Goldreich–Rosen generator.

In a secure message transmission (SMT) scenario a sender wants to send a message in a private and reliable way to a receiver. Sender and receiver are connected by \\(n\\) vertex disjoint paths, referred to as wires, \\(t\\) of which can be controlled by an adaptive adversary with unlimited computational resources. In Eurocrypt 2008, Garay and Ostrovsky considered an SMT scenario where sender and receiver have access to a public discussion channel and showed that secure and reliable communication is possible when \\(n t+1\\). In this paper we will show that a secure protocol requires at least 3 rounds of communication and 2 rounds invocation of the public channel and hence give a complete answer to the open question raised by Garay and Ostrovsky. We also describe a round optimal protocol that has constant transmission rate over the public channel.

The issue of overcapacity has become an unavoidable challenge in the rapid development of nations, constraining economic progress, particularly within industries like steel, coal, and cement. This study, using the example of the Chinese steel industry in the context of supply-side structural reform, employs data envelopment analysis (DEA) models to measure capacity utilization, and ordinary least squares (OLS) models to investigate the impact of capacity reduction policies on the steel industry’s capacity utilization pathways. The research findings indicate that capacity reduction policies have a significantly positive impact on the capacity utilization in the steel industry. They enhance capacity utilization through four pathways: “equipment optimization and upgrade”, “enterprise mergers and restructuring”, “technology innovation-driven”, and “environmental protection regulations”. Among these, “technology innovation-driven” and “environmental protection regulations” play predominant roles, while the effect of “international market expansion” on increasing capacity utilization in the steel industry is not significant. To ensure the sustained effectiveness of capacity reduction policies, the nation should continue to strengthen the “technology innovation-driven” and “environmental protection regulations” pathways. Additionally, it should activate the “national market expansion” pathway, fully exploring the potential for international cooperation to achieve improved capacity utilization in the steel industry.

The current legal and policy system of renewable energy in China has set up a framework of policy instruments, which provides an important foundation for dealing with climate change and promoting the healthy development of the renewable energy industry with the goal of “carbon neutrality” and “emission peak”. However, the current policy instruments cannot meet the needs for rapid development of the renewable energy industry. This paper investigates, analyzes, and concludes the status of renewable energy development along with related policy instruments in different renewable energy sources by literature and points out the problems of current policy instruments, and puts forward corresponding countermeasures. Moreover, from the perspective of energy consumption market transformation, the authors carried out an analysis of China’s challenges of policy instruments, pointing out that China’s renewable energy policy instruments have the potential to take one step further in the areas of the regulatory system, legal system and legal security system.

Primary female urethral carcinomas are uncommon and have a low morbidity rate. Most of these patients have advanced illness with high invasion and a poor prognosis. There is no standard treatment, and multimodal therapy is recommended. The use of radiotherapy and chemotherapy were mostly reported in previous studies on advanced female urethral squamous cell carcinoma. We report that chemotherapy combined with a programmed death-1 (PD-1) inhibitor was effective in treating metastatic female urethral squamous cell carcinoma. During four cycles, we used systemic chemotherapy of albumin-paclitaxel + carboplatin in combination with a PD-1 inhibitor (toripalimab 240 mg) every 3 weeks, and a complete response was achieved. We performed a genetic test on the patient who had a tumor mutation burden of 5.7 mutations/Mb, tumor proportion score of 20%, and combined positive score of 20% (22C3). No recurrence or distant metastasis was found after 20 months of follow-up. In conclusion, in patients with positive PD-1 ligand 1 expression in primary female urethral squamous cell carcinoma, chemotherapy combined with PD-1 inhibitors may be effective. Larger sample studies are required to determine PD-1 ligand 1 expression and the curative effect of PD-1 inhibitors, as well as their effect on survival.

[This corrects the article DOI: 10.3389/fpls.2026.1866274.].