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Promoting Positive Youth Development Through School-Based Social and Emotional Learning Interventions: A Meta-Analysis of Follow-Up Effects
This meta-analysis reviewed 82 school-based, universal social and emotional learning (SEL) interventions involving 97,406 kindergarten to high school students (Mage = 11.09 years; mean percent low socioeconomic status = 41.1; mean percent students of color = 45.9). Thirty-eight interventions took place outside the United States. Follow-up outcomes (collected 6 months to 18 years postintervention) demonstrate SEL's enhancement of positive youth development. Participants fared significantly better than controls in social-emotional skills, attitudes, and indicators of well-being. Benefits were similar regardless of students' race, socioeconomic background, or school location. Postintervention social-emotional skill development was the strongest predictor of well-being at follow-up. Infrequently assessed but notable outcomes (e.g., graduation and safe sexual behaviors) illustrate SEL's improvement of critical aspects of students' developmental trajectories.
Journal Article
Food in Vogue
\"Food in Vogue collects the most striking, mouthwatering food photography and finest food writing from one of the most respected magazines in the world. Combining legendary essays by longtime Vogue food critic Jeffrey Steingarten, as well as contributions from rising food writers such as Tamar Adler and Oliver Strand, with original behind-the-scenes interviews, the book pairs portraits of world-renowned or rising chefs along with iconic food photography, much of it shot by Irving Penn and conceived by editor Phyllis Posnick. Food in Vogue examines how Vogue's relationship with and treatment of food has changed in its pages through lavish and challenging food photographs, and its career-defining interviews with the world's hottest chefs. Food in Vogue is more than a book about food. It's a book about trends, fashion, and culture, told through the world's common language\"--Publisher's description.
Book
Cell Penetrating Peptides, Novel Vectors for Gene Therapy
Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first identified ~25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring peptides, able to carry variety of cargoes across the cellular membranes in an intact, functional form. Since their initial description and characterization, the field of cell penetrating peptides as vectors has exploded. The cargoes they can deliver range from other small peptides, full-length proteins, nucleic acids including RNA and DNA, liposomes, nanoparticles, and viral particles as well as radioisotopes and other fluorescent probes for imaging purposes. In this review, we will focus briefly on their history, classification system, and mechanism of transduction followed by a summary of the existing literature on use of CPPs as gene delivery vectors either in the form of modified viruses, plasmid DNA, small interfering RNA, oligonucleotides, full-length genes, DNA origami or peptide nucleic acids.
Journal Article
Japan : top sights, authentic experiences
\"Lonely Planet Best of Japan is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. See traditional geisha in Kyoto, hike up Mt Fuji, or shop around the clock in Tokyo; all with your trusted travel companion.\"--Publisher.
Book
Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge
The outer membrane of Gram-negative bacteria is composed of lipopolysaccharide, a large glycolipid that prevents drugs from entering the cells. Disrupting lipopolysaccharide assembly hypersensitizes bacteria to antibiotics. Sherman et al. used biochemical tools to observe lipopolysaccharide transport. Seven proteins, which are conserved in all Gram-negative bacteria, appear to form a protein bridge that uses adenosine triphosphate to power transport of lipopolysaccharide from one membrane to another. The ability to monitor intermembrane transport of lipopolysaccharide will help in efforts to develop and characterize inhibitors. Science , this issue p. 798 Reconstitution of lipopolysaccharide transport shows that a protein bridge mediates membrane-to-membrane transport using adenosine triphosphate. Gram-negative bacteria have an outer membrane that serves as a barrier to noxious agents in the environment. This protective function is dependent on lipopolysaccharide, a large glycolipid located in the outer leaflet of the outer membrane. Lipopolysaccharide is synthesized at the cytoplasmic membrane and must be transported to the cell surface. To understand this transport process, we reconstituted membrane-to-membrane movement of lipopolysaccharide by incorporating purified inner and outer membrane transport complexes into separate proteoliposomes. Transport involved stable association between the inner and outer membrane proteoliposomes. Our results support a model in which lipopolysaccharide molecules are pushed one after the other in a PEZ dispenser–like manner across a protein bridge that connects the inner and outer membranes.
Journal Article
Japan
Lonely Planet Japan is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Explore a bamboo grove in Arashiyama, marvel at Shinto and Buddhist architecture in Kyoto, or relax in the hot springs of Noboribetsu Onsen; all with your trusted travel companion.
Book
Mastering organismal aging through the endoplasmic reticulum proteostasis network
The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have demonstrated that interventions that improve the capacity to maintain endoplasmic reticulum (ER) proteostasis prolong life and healthspan. ER stress is monitored by the unfolded protein response (UPR), a signaling pathway that mediates adaptive processes to restore proteostasis or the elimination of damaged cells by apoptosis. Here, we discuss recent advances in understanding the significance of the UPR to aging and its implications for the maintenance of cell physiology of various cell types and organs. The possible benefits of targeting the UPR to extend healthspan and reduce the risk of developing age‐related diseases are also discussed. Crosstalk between aging pathways and the UPR. The interrelation between signaling pathways that regulate aging and the UPR is indicated, with key components and intervention strategies that modify the aging process.
Journal Article
If You Build It, Will They Compost? The Effects of Municipal Composting Services on Household Waste Disposal and Landfill Emissions
Composting food and garden waste generates less methane emissions than landfills, yet most organic waste is landfilled. This paper examines how local government provision of composting services affects the amount of household waste going to landfills. Using quasi-random adoption of curbside organics collection by local councils in Australia, we find that curbside organics collection diverted one-fourth of household waste from landfill to composting. We find no evidence that organics collection altered total household waste and weak evidence of a small negative spillover effect on dry-recycling waste. Our results suggest curbside organics collection could reduce emissions from landfills by 6–26%.
Journal Article
Unveiling Dietary Complexity: A Scoping Review and Reporting Guidance for Network Analysis in Dietary Pattern Research
Background/Objectives: Dietary patterns play a crucial role in health, yet most research examines foods individually, overlooking how they interact. This approach provides an incomplete picture of how diet influences health outcomes. Network analysis (e.g., Gaussian graphical models, mutual information networks, mixed graphical models) offers a more comprehensive way to study food co-consumption by capturing complex relationships between dietary components. However, while researchers have applied various network algorithms to explore food co-consumption, inconsistencies in methodology, incorrect application of algorithms, and varying results have made interpretation challenging. The objectives of this scoping review were to systematically map and synthesise studies that have applied network analysis to dietary data, and to establish guiding principles for future research in this area. Methods: Using PRISMA-ScR criteria, our scoping review identified 171 articles published from inception up to 7 March 2025, of which 18 studies met the inclusion criteria. Results: Gaussian graphical models were the most frequent approach, used in 61% of studies, and were often paired with regularisation techniques (e.g., graphical LASSO) to improve clarity (93%). The analysis revealed significant methodological challenges across the literature: 72% of studies employed centrality metrics without acknowledging their limitations, there was an overreliance on cross-sectional data limiting the ability to determine cause and effect, and difficulties in handling non-normal data. While most studies using GGM addressed the issue of non-normal data, either by using the nonparametric extension, Semiparametric Gaussian copula graphical model (SGCGM), or log-transforming the data, 36% did nothing to manage their non-normal data. Conclusions: To improve the reliability of network analysis in dietary research, this review proposes five guiding principles: model justification, design–question alignment, transparent estimation, cautious metric interpretation, and robust handling of non-normal data. To facilitate their adoption, a CONSORT-style checklist is introduced—the Minimal Reporting Standard for Dietary Networks (MRS-DN)—to help guide future studies. This review was preregistered on Open Science Framework.
Journal Article