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Mastering organismal aging through the endoplasmic reticulum proteostasis network
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Mastering organismal aging through the endoplasmic reticulum proteostasis network
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Journal Article
Mastering organismal aging through the endoplasmic reticulum proteostasis network
2020
Overview
The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have demonstrated that interventions that improve the capacity to maintain endoplasmic reticulum (ER) proteostasis prolong life and healthspan. ER stress is monitored by the unfolded protein response (UPR), a signaling pathway that mediates adaptive processes to restore proteostasis or the elimination of damaged cells by apoptosis. Here, we discuss recent advances in understanding the significance of the UPR to aging and its implications for the maintenance of cell physiology of various cell types and organs. The possible benefits of targeting the UPR to extend healthspan and reduce the risk of developing age‐related diseases are also discussed. Crosstalk between aging pathways and the UPR. The interrelation between signaling pathways that regulate aging and the UPR is indicated, with key components and intervention strategies that modify the aging process.
