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Monografija Aenona – stambena arhitektura jedinstvena je studija, koja obrađuje problematiku stambene arhitekture predrimske i rimske Enone, nastala na temelju dugogodišnjih arheoloških istraživanja autorice Marije Kolege. Uz stambenu arhitekturu, pokazuje i nove spoznaje urbanističkog razvoja antičke Enone.

Namjesnik Dalmacije za vrijeme Druge austrijske uprave, podmaršal Wenzel Alois Vetter Graf von Lilienberg (1831. – 1840.), po preuzimanju dužnosti odlučio je obići pokrajinu kako bi, po njegovim riječima, stekao vlastiti dojam i dobio valjane podatke o cjelokupnom socioekonomskom stanju. Putovanje koje je poduzeo trajalo je više od dvije godine, od 1832. do 1834. U detaljnom izvještaju vlastima u Beču iznio je opis provincije koji je obuhvaćao pregled zatečenog stanja i plan unaprjeđenja pokrajine. U jednom dijelu izvještaja iznosi opasku o Dalmatincima kao narodu koji ne mari za vlastite spomenike te ih uništava. Kao dokaz takvom ponašanju donosi crtež ulomka sarkofaga za koji piše da je iz Salone. Crtež i opis koji ga prati dio su čistopisa koji se čuva u Austrijskoj nacionalnoj knjižnici te do danas nisu objavljeni. Prikazani se spomenik čuva u Arheološkom muzeju u Zadru, a u suvremenoj se literaturi navodi da je iz okolice Zadra ili Biograda. Ovim istraživanjem, a na temelju arhivskih izvora, pokazuje se da je spomenik iz Salone, a da je u Zadar prenesen za vrijeme namjesništva grofa von Lilienberga. Wenzel Alois Vetter Graf von Lilienberg (1831-1840), governor of Dalmatia during the Second Austrian Administration, decided to tour the province after assuming office in order to, in his words, gain his own impression and obtain valid data on the overall socioeconomic situation. His journey lasted more than two years, from 1832 to 1834. In a detailed report to the authorities in Vienna, he presented a description of the province that included a survey of the current situation and a plan for improvement. In one part of the report, he makes a remark about the Dalmatians as a people negligent of their monuments and destroying them. As evidence of such behaviour, he attached a drawing of a sarcophagus fragment, allegedly from Salona. The drawing and the accompanying description are part of an unpublished manuscript kept in the Austrian National Library. The depicted monument is kept in the Archaeological Museum in Zadar, and present-day scholarly literature locates it to the surroundings of Zadar or Biograd. This research, based on archival sources, shows that the monument originated from Salona, and that it was transferred to Zadar during the governorship of Count von Lilienberg.

Monografija “Aenona – stambena arhitektura” jedinstvena je studija, koja obrađuje problematiku stambene arhitekture predrimske i rimske Enone, nastala na temelju dugogodišnjih arheoloških istraživanja autorice Marije Kolege. Uz stambenu arhitekturu, pokazuje i nove spoznaje urbanističkog razvoja antičke Enone.

Food is considered as important environmental factor that plays a role in development of Hashimoto's thyroiditis (HT). The goal of our study was to identify food groups, assessed by food frequency questionnaire, that differ in consumption frequency between 491 patients with HT and 433 controls. We also analysed association of food groups with the wealth of HT-related clinical traits and symptoms. We found significantly increased consumption of animal fat (OR 1.55, p  < 0.0001) and processed meat (OR 1.16, p  = 0.0012) in HT cases, whereas controls consumed significantly more frequently red meat (OR 0.80, p  < 0.0001), non-alcoholic beverages (OR 0.82, p  < 0.0001), whole grains (OR 0.82, p  < 0.0001) and plant oil (OR 0.87, p  < 0.0001). We also observed association of plant oil consumption with increased triiodothyronine levels in HT patients (β = 0.07, p  < 0.0001), and, association of olive oil consumption with decreased systolic blood pressure (β = − 0.16, p  = 0.001) in HT patients on levothyroxine (LT4) therapy. Analysis of food consumption between HT patients with and without LT4 therapy suggest that patients do not tend to modify their diet upon HT diagnosis in our population. Our study may be of relevance to nutritionists, nutritional therapists and clinicians involved in developing dietary recommendations for HT patients.

The aims of this study were to evaluate: (1) associations of vitamin D with the presence/severity of Hashimoto’s thyroiditis (HT) and (2) correlations of vitamin D with thyroid-related phenotypes. Total 25(OH)D (vitamin D in the text) was measured from stored serum samples of 461 HT patients and 176 controls from a Croatian Biobank of HT patients (CROHT). (1) Vitamin D levels, and proportions of vitamin D deficiency, were compared between HT cases and controls. HT patients were additionally divided into two groups (MILD and OVERT) to take into account HT severity. (2) Correlations between vitamin D and 10 clinical phenotypes in all HT patients and two subgroups of HT patients were tested using the Spearman correlation test. Our analyses were adjusted for age, gender, BMI, smoking status and seasonality of blood sampling. (1) No significant differences in vitamin D levels, or proportions of vitamin D deficiency, were detected between HT patients of all disease stages and controls. However, a nominally significant difference in vitamin D levels between MILD and OVERT subgroups (OR = 1.038, p = 0.023) was observed. Proportions of individuals with vitamin D deficiency during winter–spring were high: all HT cases (64.69%), MILD (60.64%), OVERT (68.7%), controls (60.79%). (2) A nominally significant negative correlation between vitamin D and TSH in all HT patients (r = −0.113, p = 0.029) and a positive correlation between vitamin D and systolic blood pressure in OVERT HT patients (r = 0.205, p = 0.025) were identified. Our study indicates that there is no association between vitamin D and HT; however, there may be a subtle decrease in vitamin D levels associated with overt hypothyroidism.

In this cross-sectional observational study, we investigated whether recreational exercise (RE) influences systemic inflammation in Hashimoto’s thyroiditis (HT) across different disease severity groups. We analyzed 403 participants from the Croatian Biobank of Patients with HT (CRO-HT), including 173 controls and 230 HT patients (euthyroid, levothyroxine [LT4]-treated, and hypothyroid). Serum levels of 92 inflammatory proteins were measured using the Olink® Target 96 Inflammation panel, and exercise status was assessed via structured questionnaires. Linear regression revealed distinct protein associations depending on thyroid status. In controls, RE was associated with reduced MMP-10 and FGF-5, reflecting cardiovascular and muscle benefits. In euthyroid patients, RE was associated with decreased CXCL9 and TRAIL, implicating reduced type 1 inflammation and vascular risk. LT4-treated patients showed increases in IL-15RA and IL-24 with RE, suggesting improved muscle metabolism and anti-inflammatory effects. In hypothyroid patients, RE was associated with reduced CCL20 and increased HGF, while changes in TRANCE and TWEAK indicated mixed effects on bone and immune regulation. Notably, RE was associated with reduced CXCL9 and CCL20, two proteins previously linked to HT risk. Overall, RE is associated with distinct changes in inflammatory profiles across HT disease severity groups, with the most favourable responses observed in LT4-treated patients, suggesting synergy with hormone therapy.

Thyroid antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) are key markers of Hashimoto’s thyroiditis (HT), the most common autoimmune thyroid disorder. Genetic determinants of thyroid antibodies are still poorly known, especially as they were not studied in patients with thyroid diseases. We performed the first genome-wide association analysis of thyroid antibodies in 430 HT patients that may be considered as population extremes for thyroid antibodies distribution. We detected two suggestively associated genetic variants with TgAb, rs6972286 close to ANKRD7 and LSM8 (P = 2.34 × 10 −7 ) and rs756763 inside CA10 (P = 6.05 × 10 −7 ), and one with TPOAb, rs12507813 positioned between TRIM61 and TRIM60 (P = 4.95 × 10 −7 ). Bivariate analysis resulted with three suggestively associated genetic variants that predispose to both antibodies: rs13190616 inside RP11-138J23.1 (P = 2.01 × 10 −6 ), rs561030786 close to DUBR (P = 7.33 × 10 −6 ) and rs12713034 inside FSHR (P = 7.66 × 10 −6 ). All identified genomic regions have a substantial literature record of involvement with female-related traits, immune-mediated diseases and personality traits that are all characterized by increased thyroid antibody levels. Our findings demonstrate the existence of genetic overlap between thyroid autoimmunity in HT and different non-thyroid diseases characterized by the presence of thyroid antibodies. We also suggest that genetic variants that regulate antibody levels may differ between HT patients and individuals with normal thyroid function.