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"Wanders, Marcel"
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Rijks : masters of the Golden Age : paintings from the Gallery of Honour
A visit to an historic museum offers visitors insight into the social, cultural, political and aesthetic values of times gone by. Yet truly great works of art live vividly, continuing to thrill and educate for centuries regardless of age. This idea of timelessness is the theme explored in Marcel Wanders' new book publication \"Masters of the Golden Age: Paintings from the Gallery of Honour\". Closed for many years for redevelopment, the 2013 reopening of the Rijksmuseum in Amsterdam and especially the Gallery of Honour is cause for both celebration, and an opportunity for a fresh interpretation of the works that sit within. The key to true connection is the ability to understand the contemporary relevance of historic images. Within \"Rijks, Masters of the Golden Age: Paintings from the Gallery of Honour\", Marcel Wanders seeks to explore the timelessness of select artworks and to expose their contemporary significance. The book also features interviews with thirty experts across a variety of fields that discuss elements held within the profiled art works.
Book
Rijks : masters of the golden age : paintings from the Gallery of Honour
A visit to an historic museum offers visitors insight into the social, cultural, political and aesthetic values of times gone by. Yet truly great works of art live vividly, continuing to thrill and educate for centuries regardless of age. This idea of timelessness is the theme explored in Marcel Wanders' new book publication \"Masters of the Golden Age : Paintings from the Gallery of Honour\". Closed for many years for redevelopment, the 2013 reopening of the Rijksmuseum in Amsterdam and especially the Gallery of Honour is cause for both celebration, and an opportunity for a fresh interpretation of the works that sit within. The key to true connection is the ability to understand the contemporary relevance of historic images. Within \"Rijks, Masters of the Golden Age: Paintings from the Gallery of Honour\", Marcel Wanders seeks to explore the timelessness of select artworks and to expose their contemporary significance. The book also features interviews with thirty experts across a variety of fields that discuss elements held within the profiled art works.
Book
modern artist
In Miami, at least, that point-of-view is fairly well evolved. [Wanders] sees the resort as the opening scene of a fairy tale. \"The moment you walk into the hotel is like waking up after a 100-year-long sleep,\" says Wanders, for whom the concept of \"happiness\" was a key design cue. It's all vaguely reminiscent of Philippe Starck, who helped launch the Morgans brand with Ian Schräger.
Trade Publication Article
Casa Son Vida
A brief report on Dutch designer Marcel Wanders' interior design of a house in Mallorca, Spain. The house features a curving relief wall of glossy white combined with pieces of Wanders' brightly coloured furniture.
Magazine Article
NO 13 Droog Design Collective
Droog changed everything. From its first exhibition at the furniture fair in Milan in 1993, the ragtag group of Dutch furniture, lighting, graphic, and product designers-- who collaborate under the loose affiliation of what founders Gijs Bakker, a jewelry designer, and Renny Ramakers, a design critic, call \"a brand and a mentality\"-- had begun to undermine the global design scene's steadfast allegiance to new looks and product innovation.
Magazine Article
Lovastatin in X-Linked Adrenoleukodystrophy
To the Editor:
As reported previously in the
Journal,
lovastatin lowers levels of very-long-chain fatty acids in plasma in patients with X-linked adrenoleukodystrophy (X-ALD).
1
Further studies did not reproduce this finding with the use of simvastatin in patients or with the use of lovastatin in X-ALD–knockout mice.
2
,
3
Still, many patients with X-ALD worldwide receive lovastatin.
We conducted a randomized, double-blind, placebo-controlled, crossover trial comparing lovastatin at a dose of 40 mg once daily with placebo (Current Controlled Trials number, ISRCTN31565393). Outcome measures were levels of hexacosanoic acid (C26:0) in plasma, low-density lipoprotein (LDL) particles, lymphocytes and erythrocytes, and plasma . . .
Journal Article
A mutation in an alternative untranslated exon of hexokinase 1 associated with Hereditary Motor and Sensory Neuropathy – Russe (HMSNR)
Hereditary Motor and Sensory Neuropathy – Russe (HMSNR) is a severe autosomal recessive disorder, identified in the Gypsy population. Our previous studies mapped the gene to 10q22-q23 and refined the gene region to ∼70 kb. Here we report the comprehensive sequencing analysis and fine mapping of this region, reducing it to ∼26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (
HK1)
. We identified two sequence variants in complete linkage disequilibrium, a G>C in a novel alternative untranslated exon (AltT2) and a G>A in the adjacent intron, segregating with the disease in affected families and present in the heterozygote state in only 5/790 population controls. Sequence conservation of the AltT2 exon in 16 species with invariable preservation of the G allele at the mutated site, strongly favour the exonic change as the pathogenic mutation. Analysis of the
Hk1
upstream region in mouse mRNA from testis and neural tissues showed an abundance of AltT2-containing transcripts generated by extensive, developmentally regulated alternative splicing. Expression is very low compared with ubiquitous
Hk1
and all transcripts skip exon1, which encodes the protein domain responsible for binding to the outer mitochondrial membrane, and regulation of energy production and apoptosis. Hexokinase activity measurement and immunohistochemistry of the peripheral nerve showed no difference between patients and controls. The mutational mechanism and functional effects remain unknown and could involve disrupted translational regulation leading to increased anti-apoptotic activity (suggested by the profuse regenerative activity in affected nerves), or impairment of an unknown HK1 function in the peripheral nervous system (PNS).
Journal Article