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Solid‐state lithium battery promises highly safe electrochemical energy storage. Conductivity of solid electrolyte and compatibility of electrolyte/electrode interface are two keys to dominate the electrochemical performance of all solid‐state battery. By in situ polymerizing poly(ethylene glycol) methyl ether acrylate within self‐supported three‐dimensional porous Li1.3Al0.3Ti1.7(PO4)3 framework, the as‐assembled solid‐state battery employing 4.5 V LiNi0.8Mn0.1Co0.1O2 cathode and Li metal anode demonstrates a high Coulombic efficiency exceeding 99% at room temperature. Solid‐state nuclear magnetic resonance results reveal that Li+ migrates fast along the continuous Li1.3Al0.3Ti1.7(PO4)3 phase and Li1.3Al0.3Ti1.7(PO4)3/polymer interfacial phase to generate a fantastic conductivity of 2.0 × 10−4 S cm−1 at room temperature, which is 56 times higher than that of pristine poly(ethylene glycol) methyl ether acrylate. Meanwhile, the in situ polymerized poly(ethylene glycol) methyl ether acrylate can not only integrate the loose interfacial contact but also protect Li1.3Al0.3Ti1.7(PO4)3 from being reduced by lithium metal. As a consequence of the compatible solid‐solid contact, the interfacial resistance decreases significantly by a factor of 40 times, resolving the notorious interfacial issue effectively. The integrated strategy proposed by this work can thereby guide both the preparation of highly conductive solid electrolyte and compatible interface design to boost practical high energy density all solid‐state lithium metal battery. The poor room‐temperature ionic conductivity of solid electrolyte and incompatibility of solid–solid electrolyte/electrode interface are resolved simultaneously by in situ polymerizing electrode compatible polymer within a highly conductive, three‐dimensional self‐supported porous oxide framework. The composite solid electrolyte guided by this strategy is exploited to achieve excellent cycling performance for high‐voltage solid‐state lithium battery.

Background Osteoporosis is a genetic disease caused by the imbalance between osteoblast-led bone formation and osteoclast-induced bone resorption. However, further gene-related pathogenesis remains to be elucidated. Methods The aberrant expressed genes in osteoporosis was identified by analyzing the microarray profile GSE100609. Serum samples of patients with osteoporosis and normal group were collected, and the mRNA expression of candidate genes was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The mouse cranial osteoblast MC3T3-E1 cells were treated with dexamethasone (DEX) to mimic osteoporosis in vitro. Alizarin Red staining and alkaline phosphatase (ALP) staining methods were combined to measure matrix mineralization deposition of MC3T3-E1 cells. Meanwhile, the expression of osteogenesis related genes including alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), Osterix, and bone morphogenetic protein 2 (BMP2) were evaluated by qRT-PCR and western blotting methods. Then the effects of candidate genes on regulating impede bone loss caused by ovariectomy (OVX) in mice were studied. Results Cyclin A1 (CCNA1) was found to be significantly upregulated in serum of osteoporosis patients and the osteoporosis model cells, which was in line with the bioinformatic analysis. The osteogenic differentiation ability of MC3T3-E1 cells was inhibited by DEX treatment, which was manifested by decreased Alizarin Red staining intensity, ALP staining intensity, and expression levels of ALP, OCN, OPN, Osterix, and BMP2. The effects of CCNA1 inhibition on regulating osteogenesis were opposite to that of DEX. Then, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that genes negatively associated with CCNA1 were enriched in the TGF-beta signaling pathway. Inhibitor of TGF-beta signaling pathway partly reversed osteogenesis induced by suppressed CCNA1. Furthermore, suppressed CCNA1 relieved bone mass of OVX mice in vivo. Conclusion Downregulation of CCNA1 could activate TGF-beta signaling pathway and promote bone formation, thus playing a role in treatment of osteoporosis.

Dual-task walking is a good paradigm to measure the walking ability of stroke patients in daily life. It allows for a better observation of brain activation under dual-task walking to assess the impact of the different tasks on the patient when combining with functional near-infrared spectroscopy (fNIRS). This review aims to summarize the cortical change of the prefrontal cortex (PFC) detected in single-task and dual-task walking in stroke patients. Six databases (Medline, Embase, PubMed, Web of Science, CINAHL, and Cochrane Library) were systematically searched for relevant studies, from inception to August 2022. Studies that measured the brain activation of single-task and dual-task walking in stroke patients were included. The main outcome of the study was PFC activity measured using fNIRS. In addition, a subgroup analysis was also performed for study characteristics based on HbO to analyze the different effects of disease duration and the type of dual task. Ten articles were included in the final review, and nine articles were included in the quantitative meta-analysis. The primary analysis showed more significant PFC activation in stroke patients performing dual-task walking than single-task walking ( = 0.340, = 0.02, = 7.853%, 95% = 0.054-0.626). The secondary analysis showed a significant difference in PFC activation when performing dual-task walking and single-task walking in chronic patients ( = 0.369, = 0.038, = 13.692%, 95% = 0.020-0.717), but not in subacute patients ( = 0.203, = 0.419, = 0%, 95% = -0.289-0.696). In addition, performing walking combining serial subtraction ( = 0.516, < 0.001, = 0%, 95% = 0.239-0.794), obstacle crossing ( = 0.564, = 0.002, = 0%, 95% = 0.205-0.903), or a verbal task ( = 0.654, = 0.009, = 0%, 95% = 0.164-1.137) had more PFC activation than single-task walking, while performing the n-back task did not show significant differentiation ( = 0.203, = 0.419, = 0%, 95% = -0.289-0.696). Different dual-task paradigms produce different levels of dual-task interference in stroke patients with different disease durations, and it is important to choose the matching dual-task type in relation to the walking ability and cognitive ability of the patient, in order to better improve the assessment and training effects. https://www.crd.york.ac.uk/prospero/, identifier: CRD42022356699.

Background Technology integration in education is widespread, but its impact on physical education (PE) teachers’ self-determined motivation, job satisfaction, and organizational commitment remains insufficiently understood, especially in short-term, practice-oriented professional development (PD) formats tailored to PE. Objectives Grounded in Self-Determination Theory (SDT), this study examined whether a technology-enhanced, sports-training-informed PD workshop (delivered through structured, video-guided sessions) influences PE teachers’ job satisfaction, self-determined motivation, and organizational commitment. Methodology Data were collected in 2014 using a quasi-experimental pretest–posttest control-group design. A total of 300 full-time physical education (PE) teachers from primary and secondary schools across multiple regions of China completed baseline questionnaires; following eligibility screening, 60 teachers ( n  = 30 intervention; n  = 30 control) were selected for the intervention phase and completed pretest–posttest measures of job satisfaction, self-determined motivation, and organizational commitment. Results The intervention group showed clear gains in self-determined motivation and job satisfaction relative to the control group. Changes in organizational commitment were mixed and did not exhibit the same strength or consistency as those of motivation and job satisfaction. Conclusions Technology-enhanced, sports training-informed PD may meaningfully strengthen PE teachers’ motivational functioning and work-related satisfaction, likely by supporting autonomy, competence, and relatedness. However, organizational commitment may require longer or more system-level interventions to be reliably shifted. Given the brief duration and reliance on self-report measures, claims about long-term impact should be treated with caution.

Bombyx batryticatus (BB) is an anticonvulsant animal medicine in traditional Chinese medicine (TCM) and acts on the central nervous system. This research aimed to study the anticonvulsant effects of different polarity fractions of extracts from BB and to explore the components conferring anticonvulsant activity. Materials and methods: Crude extracts of BB at 20 g/kg were divided into different polarity fractions (petroleum ether, chloroform, ethyl acetate, water) and were administered to groups of mice before injecting pentylenetetrazol (PTZ) to induce convulsions. The animals were placed in chambers, and their behaviors were recorded for 30 min following the injection. Latency time, percent of protection, convulsion, convulsion rate, and convulsion score were determined for these mice. The compounds present in the different fractions were analyzed, and those from the fraction that conferred anticonvulsant activity were identified by high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF MS) and molecular networking (MN). The chloroform extract fractions (B-C) clearly increased the seizure latency time and protection percentage and decreased the convulsion percentage compared to the control group. The anticonvulsant effect of other extract fractions was not significant. Our study shows that the chloroform extract fractions (B-C) of BB have a significant anticonvulsant effect. We also identified 17 compounds including lumichrome, pheophorbide A, and episyringaresinol 4′-O-beta-d-glucopyranose that were found for the first time. The results of this study may lay the groundwork for studying compounds derived from Bombyx batryticatus and their anticonvulsant effect.

Cancer is characterized by chromosomal instability (CIN), which leads to tumor heterogeneity and other malignant features. CIN is caused by abnormal centromere and kinetochore function, which results in aneuploidy, rearrangements, and micronucleus production. Centromere and kinetochore gene misexpression plays a vital role in tumor progression. Here we show that Centromere Protein T (CENPT) is highly expressed in renal carcinoma (RCC) and promotes the tumor proliferation and metastasis of RCC. CENPT is found to be critical for regulating the glutathione (GSH) metabolism pathway because it interacts with γ-glutamyl-cysteine ligase catalytic subunit (GCLC), consequently reducing reactive oxygen species levels and inhibiting ferroptosis. Mechanistically, CENPT increases the catalytic activity of GCLC by directly binding to GCLC ∆213-424aa competitively with glutamate-cysteine ligase modifier subunit (GCLM), consequently induces the GSH synthesis. In turn, GSH increases CENPT expression via transcriptional regulation mediated by the transcription factor ATF2, forming a CENPT-GCLC-GSH feedback loop that enhances the pro-carcinogenic effect of this axis in RCC. Our study identifies CENPT a potential target for RCC via forming a CENPT-GCLC-GSH feedback loop to inhibit ferroptosis. This may support a promising treatment strategy for RCC.

Erysipelas, an acute bacterial infection affecting the dermis and lymphatic system, poses significant clinical challenges due to recurrence, antibiotic resistance, and diagnostic overlap with other skin infections. Despite growing research in this area, a comprehensive bibliometric analysis is lacking, leaving gaps in understanding the publication trends, key research hotspots, and collaborative networks that shape the field. This study conducted a bibliometric analysis of erysipelas research from 2000 to 2024 using the Science Citation Index Expanded (SCI-EXPANDED) within the Web of Science Core Collection. English-language articles and reviews were selected, and data were analyzed using VOSviewer, Bibliometrix, and CiteSpace to visualize publication volume, co-authorship networks, geographic distribution, keyword trends, and collaborations. The results indicate a steady growth in erysipelas research from 2000 to 2024, with annual publication volumes increasing from 9 articles in 2000 to 30 articles in 2022, reflecting a significant rise in interest within the field. The United States leads in contributions with 69 publications and 2,739 citations, institutional analysis highlights Radboud University, Karolinska Institute, and others as key contributors in collaboration and citation impact. Keyword co-occurrence analysis identifies major research hotspots, including familial Mediterranean fever, lymphedema therapy, and the management of complex skin infections, with emerging themes like \"liposuction\" and \"skin and soft tissue infections\" gaining attention in recent years. This study highlights the growing advancements in erysipelas research, including insights into risk factors, diagnostics, and therapies, while emphasizing the need for continued collaboration and innovation to address challenges like antibiotic resistance, recurrence, and accurate differentiation from similar conditions.

To examine prefrontal hemodynamic changes in patients with post-stroke anxiety (PSA), both at rest and during cognitive task engagement, with the aim of elucidating the underlying neural mechanisms of PSA and identifying potential neural correlates for clinical application. Fifty patients with PSA and 45 post-stroke patients without anxiety symptoms were recruited. PSA was diagnosed using the Hamilton Anxiety Rating Scale (HAMA ≥ 7), and comorbid depression was screened using the 17-item Hamilton Depression Rating Scale (HAMD-17 ≥ 8). Patients with significant cognitive impairment were excluded. Functional near-infrared spectroscopy (fNIRS) was used to measure resting-state functional connectivity in the frontopolar cortex (FPC) and dorsolateral prefrontal cortex (DLPFC), as well as task-evoked activation during the verbal fluency task (VFT). Demographic and clinical characteristics showed no significant differences between groups except for stroke type. Between-group comparisons were conducted to identify PSA-related differences in prefrontal network characteristics. Subgroup analyses were performed to explore the influence of comorbid depression on neural alterations. There were no significant differences between the PSA and non-PSA groups in demographic or clinical characteristics, including age, sex, and disease duration ( > 0.05). Compared to the non-PSA group, patients with PSA exhibited significantly reduced activation in the bilateral FPC during the VFT ( < 0.05). Within the PSA group, those with comorbid depression showed further reductions in activation in the bilateral FPC and the left DLPFC ( < 0.05). No significant differences in resting-state functional connectivity were observed between groups ( > 0.05). Reduced activation in the bilateral FPC may represent a key neural substrate associated with post-stroke anxiety. In addition, altered activation patterns in the bilateral FPC and left DLPFC may reflect neural correlates related to depressive symptoms in patients with PSA, providing candidate targets for future mechanistic and clinical studies.

The n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited. This study aims to investigate age-related differences in brain activation during the n-back task using fNIRS. fNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups. Significant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group's performance plateaued at the 2-back level, along with a decline in prefrontal activation. These findings may suggest potential markers for cognitive decline, providing a new target for future screening.

Background: The cortex and cerebellum have a closely connected closed-loop circuit. Intermittent theta burst stimulation (iTBS) targeting the cerebellum has shown promise in improving balance function and inducing neuroplasticity. This study investigates whether cerebellar iTBS can elicit cortical responses. Methods: One hundred healthy volunteers were randomly assigned to a real or sham iTBS stimulation group. Functional near-infrared spectroscopy (fNIRS) measured cortical activation during resting, walking, and unilateral support tasks. Results: During the unilateral support task, graph theory analysis revealed significant changes in brain network properties, suggesting a deviation from optimal small-world organization and reduced global integration. No significant changes were observed during the walking and resting-state tasks. Conclusions: These findings suggest that cerebellar iTBS can modulate cortical activity, though further studies are needed to confirm its clinical effects. Clinical Trial Registration: ChiCTR2300077916, https://www.chictr.org.cn/showproj.html?proj=207394.