Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
205,899
result(s) for
"Wang, Yu"
Sort by:
Geomechanical behaviors of bimrocks
\"This book is intended as a reference book for advanced graduate students and research engineers in block-in-matrix rocks (bimrocks) or soil and rock mixtures (SRMs) or rock and soil aggregate (RSA). Bimrocks are complex formations characterized by competent rock inclusions floating in a weaker matrix. Typical types of bimrocks include a series of mixed geological or engineering masses such as mélanges, fault rocks, coarse pyroclastic rocks, breccias, sheared serpentines and waste dump mixture. Bimrock is especially different from the general soil and rock material, and the detection of the damage and fracture is still wide open to innovative research. Globally, there is widespread interest in investigating the geomechanical behaviors of bimrocks, such as deformation and strength characteristics, damage and fracture evolution and stability prediction of bimrock construction. However, the meso-structure factors control the whole mechanical properties of bimrocks, the source of the macroscopic deformation phenomenon is the meso-structural changes. Therefore, evaluation of the mesoscopic physical and mechanical properties, together with advanced testing technique, are attractive research topics in rock mechanics. As a result, comprehensive macroscopic and mesoscopic experimental investigations should be conducted to reveal the damage and fracturing mechanical behaviors of bimrock. The readers of this work can gain new insights into the meso-structural changes of bimrocks subjected to different stress paths. The book is expected to improve the understanding of the mesoscopic damage and fracturing mechanisms of bimrocks and can be helpful to predict the stability of rock structures where rock mass is subjected to complex loading conditions\"-- Provided by publisher.
BOOK
Eighteen Novel Bioactive Peptides from Monkfish (Lophius litulon) Swim Bladders: Production, Identification, Antioxidant Activity, and Stability
In the study, papain was chosen from five proteases to hydrolyze proteins of monkfish swim bladders for effectively utilizing monkfish (Lophius litulon) processing byproducts, and the hydrolysis conditions of papain were optimized as hydrolysis temperature of 65 °C, pH 7.5, enzyme dose 2.5% and time 5 h using single-factor and orthogonal experiments. Eighteen peptides were purified from the swim bladder hydrolysate of monkfish by ultrafiltration and gel permeation chromatography methods and identified as YDYD, QDYD, AGPAS, GPGPHGPSGP, GPK, HRE, GRW, ARW, GPTE, DDGGK, IGPAS, AKPAT, YPAGP, DPT, FPGPT, GPGPT, GPT and DPAGP, respectively. Among eighteen peptides, GRW and ARW showed significant DPPH· scavenging activities with EC50 values of 1.053 ± 0.003 and 0.773 ± 0.003 mg/mL, respectively; YDYD, QDYD, GRW, ARW and YPAGP revealed significantly HO· scavenging activities with EC50 values of 0.150 ± 0.060, 0.177 ± 0.035, 0.201 ± 0.013, 0.183 ± 0.0016 and 0.190 ± 0.010 mg/mL, respectively; YDYD, QDYD, ARW, DDGGK and YPAGP have significantly O2−· scavenging capability with EC50 values of 0.126 ± 0.0005, 0.112 ± 0.0028, 0.127 ± 0.0002, 0.128 ± 0.0018 and 0.107 ± 0.0002 mg/mL, respectively; and YDYD, QDYD and YPAGP showed strong ABTS+· scavenging ability with EC50 values of 3.197 ± 0.036, 2.337 ± 0.016 and 3.839 ± 0.102 mg/mL, respectively. YDYD, ARW and DDGGK displayed the remarkable ability of lipid peroxidation inhibition and Ferric-reducing antioxidant properties. Moreover, YDYD and ARW can protect Plasmid DNA and HepG2 cells against H2O2-induced oxidative stress. Furthermore, eighteen isolated peptides had high stability under temperatures ranging from 25–100 °C; YDYD, QDYD, GRW and ARW were more sensitive to alkali treatment, but DDGGK and YPAGP were more sensitive to acid treatment; and YDYD showed strong stability treated with simulated GI digestion. Therefore, the prepared antioxidant peptides, especially YDYD, QDYD, GRW, ARW, DDGGK and YPAGP from monkfish swim bladders could serve as functional components applied in health-promoting products because of their high-antioxidant functions.
Journal Article
The Taiwan voter
\"The Taiwan Voter examines the critical role ethnic and national identities play in politics, utilizing the case of Taiwan. Although elections there often raise international tensions, and have led to military demonstrations by China, no scholarly books have examined how Taiwan's voters make electoral choices in a dangerous environment. Critiquing the conventional interpretation of politics as an ideological battle between liberals and conservatives, The Taiwan Voter demonstrates in Taiwan the party system and voters' responses are shaped by one powerful determinant of national identity--the China factor. Taiwan's electoral politics draws international scholarly interest because of the prominent role of ethnic and national identification. While in most countries the many tangled strands of competing identities are daunting for scholarly analysis, in Taiwan the cleavages are powerful and limited in number, so the logic of interrelationships among issues, partisanship, and identity are particularly clear. The Taiwan Voter unites experts to investigate the ways in which social identities, policy views, and partisan preferences intersect and influence each other.These novel findings have wide applicability to other countries, and will be of interest to a broad range of social scientists interested in identity politics\"-- Provided by publisher.
Book
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma
The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients’ paratumors, localized/advanced tumors, initially-treated/recurrent lymph nodes and radioactive iodine (RAI)-refractory distant metastases, covering comprehensive clinical courses of PTC. Our data identifies a “cancer-primed” premalignant thyrocyte population with normal morphology but altered transcriptomes. Along the developmental trajectory, we also discover three phenotypes of malignant thyrocytes (follicular-like, partial-epithelial-mesenchymal-transition-like, dedifferentiation-like), whose composition shapes bulk molecular subtypes, tumor characteristics and RAI responses. Furthermore, we uncover a distinct
BRAF
-like-B subtype with predominant dedifferentiation-like thyrocytes, enriched cancer-associated fibroblasts, worse prognosis and promising prospect of immunotherapy. Moreover, potential vascular-immune crosstalk in PTC provides theoretical basis for combined anti-angiogenic and immunotherapy. Together, our findings provide insight into the PTC ecosystem that suggests potential prognostic and therapeutic implications.
The characterisation of the papillary thyroid carcinoma (PTC) tumour microenvironment remains crucial. Here, the authors perform single-cell RNA sequencing in 11 patients and identify potential opportunities for the use of immunotherapy and its combination with anti-angiogenic therapy in PTC.
Journal Article
Lee Kuan Yew through the eyes of Chinese scholars
\"A compilation of essays by highly-respected Chinese scholars in which they evaluate the life, work and philosophy of Lee Kuan Yew, founding Prime Minister of Singapore. Presenting a range of views from a uniquely Chinese/Asian perspective, this book provides valuable insights for those who wish to gain a fuller and deeper understanding of Lee Kuan Yew, the man, as well as Singapore, his nation\"-- Provided by publisher.
Book
From bulk, single-cell to spatial RNA sequencing
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology.
Journal Article
Metabolite profiling of human‐originated Lachnospiraceae at the strain level
The human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the human GI tract. Beneficial and adverse effects of the Lachnospiraceae on host health were reported, but the diversities at species/strain levels as well as their metabolites of Lachnospiraceae have been, so far, not well documented. In the present study, we report on the collection of 77 human‐originated Lachnospiraceae species (please refer hLchsp, https://hgmb.nmdc.cn/subject/lachnospiraceae) and the in vitro metabolite profiles of 110 Lachnospiraceae strains (https://hgmb.nmdc.cn/subject/lachnospiraceae/metabolites). The Lachnospiraceae strains in hLchsp produced 242 metabolites of 17 categories. The larger categories were alcohols (89), ketones (35), pyrazines (29), short (C2–C5), and long (C > 5) chain acids (31), phenols (14), aldehydes (14), and other 30 compounds. Among them, 22 metabolites were aromatic compounds. The well‐known beneficial gut microbial metabolite, butyric acid, was generally produced by many Lachnospiraceae strains, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 were the top 2 butyric acid producers, as 331.5 and 310.9 mg/L of butyric acids were produced in vitro, respectively. Further analysis of the publicly available cohort‐based volatile‐metabolomic data sets of human feces revealed that over 30% of the prevailing volatile metabolites were covered by Lachnospiraceae metabolites identified in this study. This study provides Lachnospiraceae strain resources together with their metabolic profiles for future studies on host–microbe interactions and developments of novel probiotics or biotherapies. The human‐originated Lachnospiraceae biobank included 77 species was constructed. In vitro metabolite profiling of 110 Lachnospiraceae strains yielded 242 metabolites of 17 categories. Many Lachnospiraceae strains produce short‐chain fatty acids, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 are the top two butyric acid producers in vitro. Highlights The human‐originated Lachnospiraceae biobank included 77 species was constructed. In vitro metabolite profiling of 110 Lachnospiraceae strains yielded 242 metabolites of 17 categories. Many Lachnospiraceae strains produce SCFAs, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 are the top two butyric acid producers in vitro.
Journal Article
Asian Summer Monsoon and Orographic Winds Change the Pollen Flow in the Hengduan Mountains, Southwestern China
Unlike plains, mountains provide diverse habitats for various biomes due to complex topography and large altitudinal differences. It is crucial for objectively reconstructing deep‐time biodiversity changes that the pollen source, dispersal, and driving forces in montane ecosystems are studied. Here, we investigate surface soil samples from different vertical zones in the Hengduan Mountains. Results show the pollen assemblages generally reflect the dominant components of the warm temperate coniferous forest and the cold temperate coniferous and sclerophyllous oak mixed forest, but exotic anemophilous pollen like Pinus (53.4%), Alnus (3.5%), Tsuga (1.1%), and Juglans (0.5%) are found in the subalpine scrub and meadows by upslope flow. The atmospheric reanalysis data suggests that the Asian summer monsoon and diurnally‐varying orographic winds may jointly drive the upslope and downslope pollen flows. These new findings provide basic scientific data and potential interpretations for the reconstructions of past vegetation and plant diversity in global montane ecosystems. Plain Language Summary The origin and evolution of plant diversity in montane ecosystems at global biodiversity hotspots is of great importance to the scientific community. Research on modern pollen depositional processes provides indispensable data for reconstructing past plant diversity. We reveal the pollen source, dispersal, and driving forces in montane ecosystems in the biodiversity hotspot of southwestern China. The Asian summer monsoon and diurnal orographic winds jointly drive the pollen flow. Our new findings provide scientific data and potential interpretation for deep‐time reconstruction of vegetation and plant diversity in montane ecosystems throughout the world. Key Points Exotic anemophilous pollen grains from low altitude are found in the subalpine scrub and meadows by upslope flow The Asian summer monsoon and diurnally‐varying orographic winds may jointly drive the upslope and downslope pollen flows in the region
Journal Article