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Explore the captivating Baltic nation of Estonia on this breathtaking aerial journey which travels from the enchanting, UNESCO-certified streets of Tallinn’s medieval Old Town to the serene flood lands of Soomaa, which locals navigate by boat. Across all four seasons, discover Estonia's best-kept secrets, from high-tech architecture to charming coastal resorts, and from traditional forest saunas to staggeringly pristine natural landscapes. Beyond the fascinating locations is a rich heritage of ancient landmarks, charming villages, ex-soviet districts, and a world-leading tech hub. Estonia from Above is the definitive tour of the tiny baltic country with big things to offer.

From spreading lies about politicians or business moguls to promoting or slandering a particular celebrity, the ‘Troll Armies’ of The Philippines are hired keyboard warriors working around the clock, furiously posting on thousands of fake social media accounts. Join us as we investigate the people behind the troll armies, how they operate and how they can be stopped.

Five million people live in a land area smaller than New York City. To make such a small and highly urbanized place livable, Singapore is embarking on its most ambitious project to date. Gardens by the Bay is a mega structure unlike anything else on earth. Three massive gardens – the size of 177 football pitches – will house thousands of plants from all over the planet. Two giant conservatories are to be constructed to protect millions of dollars’ worth of trees, flowers and plants and man-made vertical gardens called Supertrees will stretch as high as 50 meters in to the sky. This is the country’s most ambitious greening project to date and no one has ever attempted such designs before. ‘Gardens by the Bay’ is a awe-inspiring marvel where cutting edge engineering meets the green designs of tomorrow.

How is it being seduced by Glynis Barber? Would you have preferred Jerry Hall? It's a question that confronts any actor taking on the mantle of Benjamin Braddock, the young man just out of college who becomes entangled in a love- triangle with an older family friend, Mrs Robinson, and her daughter, Elaine. The actor [Andres Williams] is the latest to play [Benjamin, Williams] in the West End play of the The Graduate, now to tour around the country, opposite Barber's Mrs Robinson.

The brand new flying field for tan GI's, which was sponsored by American Legion Post 199 of this city, is now in full operation. Adjutant William Mitchell and other officials of the post are to be congratulated on their campaign for the field in our section.

This phase 3 trial showed that treatment with volanesorsen, an antisense oligonucleotide drug complementary to mRNA encoding apolipoprotein C-III, resulted in a mean reduction in triglyceride levels of 77% over the course of 3 months.

Epithelial-mesenchymal transition (EMT) have been extensively characterized in development and cancer, and its dynamics have been modeled as a non-linear process. However, less is known about how such dynamics may affect its biological impact. Here, we use mathematical modeling and experimental analysis of the TGF-β-induced EMT to reveal a non-linear hysteretic response of E-cadherin repression tightly controlled by the strength of the miR-200s/ZEBs negative feedback loop. Hysteretic EMT conveys memory state, ensures rapid and robust cellular response and enables EMT to persist long after withdrawal of stimuli. Importantly, while both hysteretic and non-hysteretic EMT confer similar morphological changes and invasive potential of cancer cells, only hysteretic EMT enhances lung metastatic colonization efficiency. Cells that undergo hysteretic EMT differentially express subsets of stem cell and extracellular matrix related genes with significant clinical prognosis value. These findings illustrate distinct biological impact of EMT depending on the dynamics of the transition. The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis.

[Antonio Bussi], who was military governor of the northern province during the dictatorship, has been accused of genocide by a Spanish judge who sought the extraditions [Nestor Kirchner] has moved to fulfill. During Bussi's tenure, 2,000 young leftist guerrillas and other regime opponents disappeared and were presumed killed. Under Spanish law, genocide can be prosecuted in Spain even if the alleged crime was committed in another country. Kirchner's lifting of the ban on extradition has not only instilled hope of prosecuting the junta figures but has \"notably changed the tone of the discussion\" of that phase in Argentine history, said Virginia Duffy, a lawyer who challenged Bussi's suitability for elected office. LEGAL REDRESS: Argentine President Nestor Kirchner, center, signs a decree clearing the way for the extradition of 46 suspects wanted in Spain on genocide charges.; PHOTOGRAPHER: Agence France-Presse

DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods, we show that phosphorylation of Saccharomyces cerevisiae Sae2 controls its capacity to promote the Mre11-Rad50-Xrs2 (MRX) nuclease to initiate resection of blocked DNA ends by at least two distinct mechanisms. First, DNA damage and cell cycle-dependent phosphorylation leads to Sae2 tetramerization. Second, and independently, phosphorylation of the conserved C-terminal domain of Sae2 is a prerequisite for its physical interaction with Rad50, which is also crucial to promote the MRX endonuclease. The lack of this interaction explains the phenotype of rad50S mutants defective in the processing of Spo11-bound DNA ends during meiotic recombination. Our results define how phosphorylation controls the initiation of DNA end resection and therefore the choice between the key DNA double-strand break repair mechanisms. It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection.