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For effective cutting tool inserts that absorb thermal shock at varying temperature gradients, improved thermal conductivity and toughness are required. In addition, parameters such as the coefficient of thermal expansion must be kept within a reasonable range. This work presents a novel material design framework based on a multi-scale modeling approach that proposes nickel (Ni)-reinforced alumina (Al 2 O 3 ) composites to tailor the mechanical and thermal properties required for ceramic cutting tools by considering numerous composite parameters. The representative volume elements (RVEs) are generated using the DREAM.3D software program and the output is imported into a commercial finite element software ABAQUS. The RVEs which contain multiple Ni particles with varying porosity and volume fractions are used to predict the effective thermal and mechanical properties using the computational homogenization methods under appropriate boundary conditions (BCs). The RVE framework is validated by the sintering of Al 2 O 3 -Ni composites in various compositions. The predicted numerical results agree well with the measured thermal and structural properties. The properties predicted by the numerical model are comparable with those obtained using the rules of mixtures and SwiftComp, as well as the Fast Fourier Transform (FFT) based computational homogenization method. The results show that the ABAQUS, SwiftComp and FFT results are fairly close to each other. The effects of porosity and Ni volume fraction on the mechanical and thermal properties are also investigated. It is observed that the mechanical properties and thermal conductivities decrease with the porosity, while the thermal expansion remains unaffected. The proposed integrated modeling and empirical approach could facilitate the development of unique Al 2 O 3 -metal composites with the desired thermal and mechanical properties for ceramic cutting inserts.

Prior data indicate similar outcomes after transplants from human leukocyte antigen (HLA)-haplotype-matched relatives, HLA-identical siblings and HLA-matched unrelated donors. We used our prospective data set to answer a clinically important question: who is the best donor for a person with acute leukaemia transplanted in first complete remission. Patients were randomly divided into training (n=611) and validation (n=588) sets. A total of 1199 consecutive subjects received a transplant from an HLA-haplotype-matched relative using granulocyte colony-stimulating factor and anti-thymocyte globulin (n=685) or an HLA-identical sibling (n=514); 3-year leukaemia-free survivals (LFSs) were 75 and 74% (P=0.95), respectively. The multivariate model identified three major risk factors for transplant-related mortality (TRM): older donor/recipient age, female-to-male transplants and donor-recipient ABO major-mismatch transplants. A risk score was developed based on these three features. TRMs were 8%, 15% and 31% for subjects with scores of 0-1, 2 and 3, respectively, (P<0.001). Three-year LFSs were 78%, 74% and 58%, respectively, (P=0.003). The risk score was validated in an independent cohort. In conclusion, our data confirm donor source is not significantly correlated with transplant outcomes. Selection of the best donor needs to consider donor-recipient age, matching for gender and ABO incompatibility among persons with acute leukaemia receiving related transplants under our transplant modality.

A steady-state thermal analysis for a hollow and axisymmetric functionally graded (FG) rotating disk with a uniform thickness was performed in this study. In the studied FG disk, metal and ceramic materials were considered for the inner and outer surfaces, respectively, when the material properties varied along the radial direction but not through material thickness variations. A power law distribution was employed to represent the material properties. Three different methods were used to present the temperature distribution along the radial direction of the FG disk, namely (1) an in-house finite element (FE) program, (2) the ANSYS parametric design language (APDL), and (3) an analytical solution. Furthermore, the in-house FE program presented the thermal stress and thermal strain of the FG disk. The weighted residual method in the FEM was used to present the temperature distribution when the material properties along an element are varying in contrast with using a commercial finite element software when the material properties are constant within an element to simulate FGMs. The accuracy of the in-house FE program was tested, and it was shown that the temperature distributions obtained by using the abovementioned methods were exactly the same. A parametric material gradation study was performed to understand the effects on the temperature, thermal strain, and stress. The material gradation was found to have a significant effect in this regard. The in-house finite element program enables one to perform a post-processing analysis in a more efficient and convenient manner than that through simulations in a finite element software program such as ANSYS. Lastly, this in-house code can be used to perform an optimization analysis to minimize the thermal strain and stress while the stiffness of the plate is maintained when the material properties within an element vary.

Encouraging results from a small sample of patients with myelodysplastic syndrome (MDS) undergoing haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) must be extended. Furthermore, an algorithm derived from a comparison of the outcomes of HID and identical-sibling donor (ISD) HSCT must be established. Therefore, the outcomes of 454 MDS patients who underwent HSCT from HIDs ( n =226) or ISDs ( n =228) between 2003 and 2013 that were reported to the Chinese Bone Marrow Transplantation Registry were analyzed. Among the 3/6 HID ( n =136), 4–5/6 HID ( n =90) and ISD patient groups, the 4-year adjusted cumulative incidences of non-relapse mortality were 34, 29 and 16%, respectively (overall P =0.004), and of relapse were 6, 7 and 10%, respectively (overall P =0.36). The 4-year adjusted probabilities of overall survival were 58, 63 and 73%, respectively (overall P =0.07), and of relapse-free-survival were 58, 63 and 71%, respectively (overall P =0.14); pairwise comparison showed that the difference was only statistically significant in the 3/6 HID vs ISD pair. The data suggest that ISDs remain the best donor source for MDS patients while HIDs (perhaps 4–5/6 HID in particular) could be a valid alternative when an ISD is not available; human leukocyte antigen disparity had no effect on survival among the HID patients.

Hematopoietic cell transplantation (HCT) activity in China was surveyed to assess its current status. A record number of HCTs (21 884: 16 631 allogeneic (76%) and 5253 autologous (24%)) were reported by 76 centers in China between 1 January 2008 and 30 June 2016. HCT trends included continued growth in transplant activity, a continued rapid increase in haploidentical donors (HID), and slower growth for unrelated donors, matched-related donors (MRD) and cord blood transplantation (CBT). The proportion of HID HCT among allogeneic HCTs increased from 29.6% (313/1062) in 2008 to 48.8% (1939/3975) in 2015, even 51.7% (1157/2237) in the first half of 2016. During this time frame, the proportion of MRD HCTs among allogeneic HCTs decreased from 48.1% (511/1062) to 33.0% (332/3975). The proportion of unrelated donor HCTs among allogeneic HCTs decreased from 20.4 (216/1062) to 13.6% (540/3975). The proportion of CBTs among allogeneic HCTs was increased from 2.1% (22/1062) to 4.2% (184/3975). HCTs have been increasing continuously for all indications except chronic myelogenous leukemia. Severe aplastic anemia is a common HCT indication among non-malignant diseases in China. The number of cases of allogeneic HCT for this disorder has increased annually, from 59 (5.6%) in 2008 to 569 (14.3%) in 2015, even 334 (14.9%) in the first half year in 2016. This survey clearly shows recent trends for HCTs in China.

We conducted a single-arm prospective study in 50 patients who received the combination of an haploidentical stem cell graft and an unrelated umbilical cord blood unit for the treatment of hematological malignancies. The median time for neutrophil engraftment was 13 days (11–20 days), and for platelets was 15 days (11–180 days). All surviving patients attained complete haploidentical engraftment except three patients who presented a mixed engraftment with increasing cord blood and decreasing haplo mismatch chimerism during the first 4 months after transplantation. The cumulative incidence of grade II–IV acute GVHD was 20%±0.327% at day+100, and the incidence of chronic GVHD was 19.26%±1.0% at 1 year. The 1-year cumulative incidence of relapse was 19.78%±1%, and the TRM was 16.2%±0.54%. At 1 year, overall survival was 78.6%±7.6% and PFS 64.0%±11.0%. The BU/CY-based conditional regimen showed a significant superiority over TBI/CY on PFS (relative risk=5.012, 95% confidence interval, 1.146–21.927, P =0.032). In conclusion, the co-infusion of an unrelated cord blood unit may potentially improve the outcome of haploidentical allogeneic hematopoietic SCT.

The purpose of this study was to evaluate the strategy of haploidentical (HID) stem cell combined with a small doses of umbilical cord blood (UCB) from a third-party donor transplantation (haplo-cord transplant) for treatment of myelodysplastic syndromes (MDS), by comparing with identical-sibling donor (ISD) transplantation. Eighty-five patients were included between January 2012 and December 2015, with a median 40 years old. Forty-eight patients received haplo-cord transplant and 37 patients received ISD transplant. Haplograft engraftment succeeded in all haplo-cord patients. For haplo-cord and ISD transplantation, adjusted cumulative incidences of grades 2–4 acute GvHD at 100 days were 27 and 11% ( P =0.059); adjusted cumulative incidences of chronic GvHD at 2 years were 22 and 34% ( P =0.215). The 2-year adjusted probabilities of overall survival were 64 and 70% ( P =0.518), and of relapse-free survival were 56 and 66% ( P =0.306). The 2-year adjusted cumulative incidences of relapse were 12 and 14% ( P =0.743), and of non-relapse mortality were 33 and 23% ( P =0.291). In conclusion, haplo-cord-HSCT achieves outcomes similar to those of ISD-HSCT for MDS and the haplo-cord-HSCT may potentially improve the outcome of HID- and UCB-HSCT alone. Thus, the haplo-cord transplantation may be a better valid alternative for MDS when an ISD is not available.

Background/Objectives: The present work was performed to investigate the association between body mass index (BMI) before transplantation and the overall survival (OS) of patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Subjects/Methods: Data from 310 adults who were diagnosed with acute leukemia and underwent allo-HSCT between March 2001 and December 2011 were analyzed. According to the suggested BMI categories for Asian population, patients with BMIs of ⩾23 and ⩾25 kg/m 2 were identified as overweight and obese, respectively. Cox proportional hazards models was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Results: The median follow-up time among the patients was 19.7 months (interquartile range=8.1–37.7). A total of 93 (34.8%) people died within the follow-up period. After adjusting for the potential confounders, normal-weight, overweight and obese patients showed significantly lower HRs than those of underweight patients, with a significant trend of OS improvement upon increasing BMI ( P =0.019). Overweight and obese patients survived longer, with a significantly decreased HR by ~40% (HR=0.60; 95% CI: 0.38–0.95) compared with underweight and normal-weight patients. Conclusions: An increased OS was seen in allo-HSCT patients with BMI⩾23 kg/m 2 compared to those with lower BMI. Further work are still needed to investigate of the effects of BMI or body composition on the survival of allo-HSCT patients.

The finite element method is used to numerically simulate the topographic development in an aluminum sheet, AA6111, under pure bending. The measured electron backscatter diffraction data are directly incorporated into the finite element model, and the constitutive response at an integration point is described by the single crystal plasticity theory. The effects of strain-rate sensitivity, work hardening, and imposed initial surface roughness on surface roughening are studied. It is found that the grains in top surface layers of the sheet play a big role in controlling the outer surface roughness due to the strain gradient across sheet thickness in bending, while the grain size and texture of the surface layers have a direct impact on finishing surface qualities.

Merging is an important operation for the generalization of land-cover data. However, current research often entails merging on a global perspective, which is not conducive to capturing the spatial characteristics of geographic objects with significant spatial structures, i.e., structured geographic objects. As such, this paper proposes an area merging method that can maintain the boundary characteristics of the structured geographic objects. First, we identify the structured geographic objects based on the description parameters of the spatial structure. Second, a Miter-type buffer transformation is introduced to extract the boundary of each structured geographic object, and area elements inside the boundary are processed with corresponding merging operations. Finally, the boundary of the structured geographic objects and the merging result of the area elements are inserted back into the aggregated result of the original land-cover data using the NOT operation. The proposed approach is experimentally validated using geographical condition census data for a city in southern China. The experimental validation indicates that the proposed approach not only reasonably identify the typical characteristics of structured geographic objects but also effectively maintains the boundary characteristics of these objects.