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Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant

by Wang, Y , Lai, Y-R , Wang, J-B , Liu, L , Gao, F , Sun, Z-M , Gao, S-J , Liu, Q-F , Wu, D-P , Jiang, M , Liu, D-H , Xu, L-P , Huang, X-J , Wang, H-X , Ou-Yang, J , Xu, K-L

in 631/67/1990/1673 / 692/67 / Adolescent / Adult / Algorithms / Anemia / Antigens / Bone marrow / Bone marrow transplantation / Cancer / Cancer Research / Care and treatment / Child / Child, Preschool / Critical Care Medicine / Development and progression / Diagnosis / Disease-Free Survival / Female / Haplotypes / Hematology / Hematopoietic stem cell transplantation / Hematopoietic Stem Cell Transplantation - methods / Hematopoietic stem cells / Histocompatibility - immunology / Histocompatibility antigen HLA / HLA Antigens - pharmacology / Humans / Intensive / Internal Medicine / Leukemia / Leukocytes / Male / Medicine / Medicine & Public Health / Middle Aged / Myelodysplastic syndrome / Myelodysplastic syndromes / Myelodysplastic Syndromes - mortality / Myelodysplastic Syndromes - therapy / Oncology / Oncology, Experimental / original-article / Patients / Recurrence / Registries / Siblings / Statistical analysis / Stem cell transplantation / Stem cells / Survival / Survival Rate / Tissue Donors / Transplantation / Transplants & implants / White blood cell count / Young Adult

2016

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Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant

by Wang, Y , Lai, Y-R , Wang, J-B , Liu, L , Gao, F , Sun, Z-M , Gao, S-J , Liu, Q-F , Wu, D-P , Jiang, M , Liu, D-H , Xu, L-P , Huang, X-J , Wang, H-X , Ou-Yang, J , Xu, K-L

2016

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Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant

by Wang, Y , Lai, Y-R , Wang, J-B , Liu, L , Gao, F , Sun, Z-M , Gao, S-J , Liu, Q-F , Wu, D-P , Jiang, M , Liu, D-H , Xu, L-P , Huang, X-J , Wang, H-X , Ou-Yang, J , Xu, K-L

2016

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Journal Article

Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant

Wang, Y,

Lai, Y-R,

Wang, J-B,

Liu, L,

Gao, F,

Sun, Z-M,

Gao, S-J,

Liu, Q-F,

Wu, D-P,

Jiang, M,

Liu, D-H,

Xu, L-P,

Huang, X-J,

Wang, H-X,

Ou-Yang, J,

Xu, K-L

2016

Overview

Encouraging results from a small sample of patients with myelodysplastic syndrome (MDS) undergoing haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) must be extended. Furthermore, an algorithm derived from a comparison of the outcomes of HID and identical-sibling donor (ISD) HSCT must be established. Therefore, the outcomes of 454 MDS patients who underwent HSCT from HIDs ( n =226) or ISDs ( n =228) between 2003 and 2013 that were reported to the Chinese Bone Marrow Transplantation Registry were analyzed. Among the 3/6 HID ( n =136), 4–5/6 HID ( n =90) and ISD patient groups, the 4-year adjusted cumulative incidences of non-relapse mortality were 34, 29 and 16%, respectively (overall P =0.004), and of relapse were 6, 7 and 10%, respectively (overall P =0.36). The 4-year adjusted probabilities of overall survival were 58, 63 and 73%, respectively (overall P =0.07), and of relapse-free-survival were 58, 63 and 71%, respectively (overall P =0.14); pairwise comparison showed that the difference was only statistically significant in the 3/6 HID vs ISD pair. The data suggest that ISDs remain the best donor source for MDS patients while HIDs (perhaps 4–5/6 HID in particular) could be a valid alternative when an ISD is not available; human leukocyte antigen disparity had no effect on survival among the HID patients.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 692/67

/ Adult

/ Anemia