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Double-walled metal-organic frameworks (MOFs), synthesized using Zn and Co, are potential porous materials for trace benzene adsorption. Aluminum is with low-toxicity and abundance in nature, in comparison with Zn and Co. Therefore, a double-walled Al-based MOF, named as ZJU-520(Al), with large microporous specific surface area of 2235 m 2  g –1 , pore size distribution in the range of 9.26–12.99 Å and excellent chemical stability, was synthesized. ZJU-520(Al) is consisted by helical chain of AlO 6 clusters and 4,6-Di(4-carboxyphenyl)pyrimidine ligands. Trace benzene adsorption of ZJU-520(Al) is up to 5.98 mmol g –1 at 298 K and P/P 0  = 0.01. Adsorbed benzene molecules are trapped on two types of sites. One (site I) is near the AlO 6 clusters, another (site II) is near the N atom of ligands, using Grand Canonical Monte Carlo simulations. ZJU-520(Al) can effectively separate trace benzene from mixed vapor flow of benzene and cyclohexane, due to the adsorption affinity of benzene higher than that of cyclohexane. Therefore, ZJU-520(Al) is a potential adsorbent for trace benzene adsorption and benzene/cyclohexane separation. Trace benzene poses a risk to the health and safety of humans, resulting in a challenging task. Here authors synthesise double-walled Al-based MOF ZJU-520(Al) with trace benzene adsorption (5.98 mmol g –1 ) and excellent benzene/cyclohexane separation ability.

Brainstem gliomas are molecularly heterogeneous diseases, many of which are difficult to safely surgically resect and have limited treatment options due to their eloquent location. These constraints pose challenges to biopsy, which limits the use of routine molecular profiling and identification of personalized therapies. Here, we explored the potential of sequencing of circulating tumor DNA (ctDNA) isolated from the cerebrospinal fluid (CSF) of brainstem glioma patients as a less invasive approach for tumor molecular profiling. CSF was obtained from patients either intraoperatively (91.2%, 52/57), from ventricular-peritoneal shunt (3.5%, 2/57), or by lumbar puncture (5.3%, 3/57), all prior to surgical manipulation of the tumor. Deep sequencing of glioma-associated genes was performed on CSF-derived ctDNA and, where available, matched blood and tumor DNA from 57 patients, including nine medullary and 23 diffuse intrinsic pontine gliomas (DIPG). At least one tumor-specific mutation was detected in over 82.5% of CSF ctDNA samples (47/57). In cases with primary tumors harboring at least one mutation, alterations were identified in the CSF ctDNA of 97.3% of cases (36/37). In over 83% (31/37) of cases, all primary tumor alterations were detected in the CSF, and in 91.9% (34/37) of cases, at least half of the alterations were identified. Among ten patients found to have primary tumors negative for mutations, 30% (3/10) had detectable somatic alterations in the CSF. Finally, mutation detection using plasma ctDNA was less sensitive than sequencing the CSF ctDNA (38% vs. 100%, respectively). Our study indicates that deep sequencing of CSF ctDNA is a reliable technique for detecting tumor-specific alterations in brainstem tumors. This approach may offer an alternative approach to stereotactic biopsy for molecular profiling of brainstem tumors.

There is less than a decade left to accomplish the goal of ending global poverty by 2030. This paper investigates global poverty dynamics and finds a shift in the world’s poverty gravity center from South Asia to Africa in the period 1990–2015. Sub-Saharan Africa has become the main battlefield for poverty reduction in the world. Global poverty reduction has been accompanied by political instability and local conflicts, economic marginalization, rural decline, and natural hazards as well as climate change which are jointly impacting the least developed areas and making the world’s poverty reduction vulnerable to external shocks. The “STAR” scheme, including maintaining political stability, promoting targeted poverty alleviation, implementing regular assessments of poverty reduction initiatives, and revitalizing rural and poverty-stricken areas, is proposed with specific measures to enhance the resilience capacity of poverty alleviation in the world.

In this study, we employed multitemporal InSAR (Interferometric Synthetic Aperture Radar) (MT-InSAR) to detect spatial and temporal ground deformations over the whole Tianjin region in the North China Plain area. Twenty-five ascending Sentinel-1A terrain observation by progressive scans (TOPS) synthetic aperture radar (SAR) scenes covering this area, acquired from 9 January 2016 to 8 June 2017, were processed using InSAR time series analysis. The deformation results derived from Sentinel-1A MT-InSAR were validated with continuously operating reference stations (CORS) at four sites and four stations of the Crustal Movement Observation Network of China (CMONOC). The overall results show good agreement, demonstrating the suitability of applying Doris with Sentinel-1A data to high-resolution monitoring of surface deformation. Significant deformation variations have been observed in different parts of Tianjin. These gradually increased from the central part of the metropolitan area to the nearby suburbs. The deformation rate of the main urban area is well-balanced and it is also relatively linear, with uplifting rates ranging from 0 to 20 mm/yr. However, due to the diversity of the geological conditions and anthropogenic activities, remarkable signs of subsidence were found in several parts of Tianjin. In particular, the south-western part of Wuqing District and western part of Beichen District showed subsidence rates of up to −136 mm/yr. We also found that, in addition to groundwater over-exploitation and lithological characteristics, additional factors also influence ground subsidence, including dynamic loads (e.g., railways), static loads (e.g., urban construction), and groundwater recharging.

Quantum-dot optoelectronics, pivotal for lighting, lasing and photovoltaics, rely on nanocrystalline oxide electron-injection layer. Here, we discover that the prevalent surface magnesium-modified zinc oxide electron-injection layer possesses poor n-type attributes, leading to the suboptimal and encapsulation-resin-sensitive performance of quantum-dot light-emitting diodes. A heavily n-doped nanocrystalline electron-injection layer—exhibiting ohmic transport with 1000 times higher electron conductivity and improved hole blockage—is developed via a simple reductive treatment. The resulting sub-bandgap-driven quantum-dot light-emitting diodes exhibit optimal efficiency and extraordinarily-high brightness, surpassing current benchmarks by at least 2.6-fold, and reaching levels suitable for quantum-dot laser diodes with only modest bias. This breakthrough further empowers white-lighting quantum-dot light-emitting diodes to exceed the 2035 U.S. Department of Energy’s targets for general lighting, which currently accounts for ~15% of global electricity consumption. Our work opens a door for understanding and optimizing carrier transport in nanocrystalline semiconductors shared by various types of solution-processed optoelectronic devices. Zheng et al. report water vapor treatment for in-situ n-doping of ZnMgO, enabling ideal ohmic electron transport and hole blockage as the electron injection layer for quantum dot light-emitting diodes, and improving the brightness and power efficiency of R/G/B LEDs for general lighting.

The complete skeleton of a new avialan dinosaur from the Tiaojishan Formation (Middle–Late Jurassic period) of Liaoning Province, China, is described and included in a comprehensive phylogenetic analysis of basal Paraves. Archaeopteryx back on its perch Discoveries of feathered theropod dinosaurs in China during the past two decades have prompted dramatic revisions of our ideas of the evolution of birds and the origins of flight — including the suggestion that the iconic fossil Archaeopteryx might have lain some distance from the ancestry of modern birds. Now Archaeopteryx is back on its perch with the discovery of yet another bird-like dinosaur, from the Tiaojishan Formation (Middle–Late Jurassic) of Liaoning Province, China. A new phylogenetic analysis restores Archaeopteryx as an early diverging avialan and realigns Troodontidae as the sister-group for Avialae. These results are consistent with early diversification of birds in Asia during the Middle–Late Jurassic, and a single origin for avian forelimb-powered flapping flight. The recent discovery of small paravian theropod dinosaurs with well-preserved feathers in the Middle–Late Jurassic Tiaojishan Formation of Liaoning Province (northeastern China) 1 , 2 , 3 , 4 has challenged the pivotal position of Archaeopteryx 3 , 4 , regarded from its discovery to be the most basal bird. Removing Archaeopteryx from the base of Avialae to nest within Deinonychosauria implies that typical bird flight, powered by the forelimbs only, either evolved at least twice, or was subsequently lost or modified in some deinonychosaurians 3 , 5 . Here we describe the complete skeleton of a new paravian from the Tiaojishan Formation of Liaoning Province, China. Including this new taxon in a comprehensive phylogenetic analysis for basal Paraves does the following: (1) it recovers it as the basal-most avialan; (2) it confirms the avialan status of Archaeopteryx ; (3) it places Troodontidae as the sister-group to Avialae; (4) it supports a single origin of powered flight within Paraves; and (5) it implies that the early diversification of Paraves and Avialae took place in the Middle–Late Jurassic period.

Brainstem gliomas are a heterogeneous group of tumors that encompass both benign tumors cured with surgical resection and highly lethal cancers with no efficacious therapies. We perform a comprehensive study incorporating epigenetic and genomic analyses on a large cohort of brainstem gliomas, including Diffuse Intrinsic Pontine Gliomas. Here we report, from DNA methylation data, distinct clusters termed H3-Pons, H3-Medulla, IDH, and PA-like, each associated with unique genomic and clinical profiles. The majority of tumors within H3-Pons and-H3-Medulla harbors H3F3A mutations but shows distinct methylation patterns that correlate with anatomical localization within the pons or medulla, respectively. Clinical data show significantly different overall survival between these clusters, and pathway analysis demonstrates different oncogenic mechanisms in these samples. Our findings indicate that the integration of genetic and epigenetic data can facilitate better understanding of brainstem gliomagenesis and classification, and guide future studies for the development of novel treatments for this disease. Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical profiles.

With the development of wireless technology, signals propagating in space are easy to mix, so blind detection of communication signals has become a very practical and challenging problem. In this paper, we propose a blind detection method for broadband signals based on a weighted bi-directional feature pyramid network (BiFPN). The method can quickly perform detection and automatic modulation identification (AMC) on time-domain aliased signals in broadband data. Firstly, the method performs a time-frequency analysis on the received signals and extracts the normalized time-frequency images and the corresponding labels by short-time Fourier transform (STFT). Secondly, we build a target detection model based on YOLOv5 for time-domain mixed signals in broadband data and learn the features of the time-frequency distribution image dataset of broadband signals, which achieves the purpose of training the model. The main improvements of the algorithm are as follows: (1) a weighted bi-directional feature pyramid network is used to achieve a simple and fast multi-scale feature fusion approach to improve the detection probability; (2) the Efficient-Intersection over Union (EIOU) loss function is introduced to achieve high accuracy signal detection in a low Signal-Noise Ratio (SNR) environment. Finally, the time-frequency images are detected by an improved deep network model to complete the blind detection of time-domain mixed signals. The simulation results show that the method can effectively detect the continuous and burst signals in the broadband communication signal data and identify their modulation types.

Arctigenin (ATG) is a broad-spectrum antitumor drug with an excellent inhibitory effect on malignant tumors such as breast cancer, glioblastoma, liver cancer, and colon cancer. However, the clinical application of ATG is limited by its poor water solubility and quick hydrolysis in the liver, intestine, and plasma, which might hinder its application. Sialic acid (SA) recognizes selectin receptors overexpressed on the surface of tumor-associated macrophages. In this study, SA was conjugated with octadecylamine (ODA) to prepare SA-ODA, which was employed to prepare SA functionalized nanoliposomes (SA-Lip) to achieve breast cancer targeting. The formulations were finely optimized using the Box–Behnken design to achieve higher ATG loading. The size, ζ potential, entrapment efficiency, drug loading, and release behavior of ATG@SA-Lip were fully investigated in comparison with conventional ATG@Lip. The ATG@SA-Lip displayed more potent cytotoxicity and higher cellular internalization compared to ATG@Sol and ATG@Lip in both MCF7 and 4T1 cells. Notably, ATG@SA-Lip showed the lowest impact on the immune system. Our study demonstrates that SA-Lip has strong potential as a delivery system for the targeted delivery of ATG.

So far, ethical leadership has been proven to have a wide range of positive effects (resource acquisition spiral). Based on resource conservation theory and implicit leadership theory, this research instead focuses on the negative effect of ethical leadership on leaders themselves through leader emotional exhaustion under the condition of employee followership, therefore leader psychological withdrawal (resource loss spiral). In this time-lagged survey, a total of n = 238 leaders (male = 65.13%) were assessed over three measurement points with an interval of three months each. The results of the stuy are: (1) Ethical leadership links to growing leader emotional exhaustion; (2) Leader emotional exhaustion associates with intensified leader psychological withdrawal; (3) Leader emotional exhaustion mediates the relation between ethical leadership and leader psychological withdrawal; (4) Employee followership reversely moderates the effect of ethical leadership on leader emotional exhaustion; (5) Employee followership reversely moderates the effect of ethical leadership on leader psychological withdrawal through leader emotional exhaustion. Its indirect effect is non-significant under the condition of high employee followership. In summary, this research interpretates the mechanism and boundary condition for the negative effects of ethical leadership on leaders themselves.