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This study aimed to enhance the prevention and control of pulmonary tuberculosis (PTB) and provide more effective and accurate methods in Changshu City. The PTB patients' information came from the China Information System for Disease Control and Prevention (CISDCP). The demographic data for Changshu city and towns came from the Suzhou Statistical Yearbook and the LandScan platform. ArcGIS was used for global spatial autocorrelation analysis and local spatial autocorrelation analysis. Univariate logistic regression and multivariate logistic regression were used to analyze the influencing factors of cured PTB patients. The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to analyze the predictive efficacy and clinical benefit of the indicators. XGBoost analysis was performed to explore the feature importance of key metrics for PTB outcome. A total of 3943 PTB cases were included. The annual incidence rate of new PTB in Changshu city was 27.081 per 100,000. Changshu High-tech Industrial Development Zone in Jiangsu Province and Shajiabang town were the high-high aggregation areas and hot spot areas. Diagnosis delay, TB strain types, and drug sensitivity were independent predictors of the cure of new PTB patients. The central and southern areas of Changshu were the high-high cluster areas and hot spots for PTB. Shorter diagnosis delay days and mycobacterium tuberculosis (MTB) promote the cure of tuberculosis, while drug sensitivity was a risk factor for its cure.

Background Long non-coding RNA 01116 (linc01116) has been shown to be dysregulated in many tumors, and is closely related to the prognosis. This meta-analysis aimed to examine the correlation between linc01116 expression and cancer prognosis. Methods Six electronic databases were searched, and eligible studies were screened based on the inclusion and exclusion criteria. Data including hazard ratios (HRs) and 95% confidence intervals (CIs), TNM stage, distant metastasis (DM) status, lymph node metastasis (LNM) status, and tumor size were extracted from the included studies. HRs and odds ratios (ORs) with their corresponding 95% CIs were separately pooled to assess the relationship between linc01116 expression and cancer prognosis. Sensitivity analysis and Begg’s test were performed to assess publication or other biases. Results A total of 12 studies involving 809 patients were included in this meta-analysis. Analysis of pooled HRs with 95% CIs showed that high linc01116 expression was significantly correlated with poor overall survival (OS) (HR = 2.096; 95% CI: 1.555–2.638), progression-free survival (PFS) (HR, 1.9314; 95% CI: 1.020–3.657), disease-free survival (DFS) (HR = 2.067; 95% CI: 1.0889–3.9238), an advanced TNM stage (OR, 1.803; 95% CI: 1.270–2.562), and a poor histological grade (OR, 1.968; 95% CI: 1.288–3.007). However, no significant correlation was observed between linc01116 expression and LNM (OR, 1.198; 95% CI: 0.831–1.728), DM (OR, 1.114; 95% CI: 0.757–1.638), tumor size (OR, 1.336; 95% CI: 0.989–1.804), depth of invasion (OR, 1.375; 95% CI: 0.756–2.501), age (OR, 0.976; 95% CI: 0.742–1.283), or sex (OR, 0.810; 95% CI: 0.599–1.094). Sensitivity analysis indicated that the overall results of OS analysis were reliable and robust. In addition, Begg’s test showed that none of the included studies had significant publication bias. Conclusion linc01116 is upregulated in most cancers, and this upregulation is associated with a poor prognosis. Therefore, linc01116 serves as a promising therapeutic target and prognostic biomarker for cancer.

The selection of safe and effective anesthetic agents for patients undergoing bariatric surgery is vital. This study aimed to evaluate the efficacy and safety of ciprofol in inducing general anesthesia in patients with obesity undergoing laparoscopic sleeve gastrectomy. A total of 212 patients scheduled for laparoscopic sleeve gastrectomy were randomly allocated into two groups in a 1:1 ratio: the ciprofol (0.5 mg/kg, n = 106) and propofol (2.5 mg/kg, n = 106) groups. The primary endpoint was to assess the success rate of anesthesia induction. Secondary endpoints included evaluating the time of induction, loss of eyelash reflex, changes in bispectral index, and adverse event incidence. The success rates of anesthesia induction were 100% in both groups. Ciprofol demonstrated non-inferiority to propofol in induction success. The times to successful induction onset and eyelash reflex disappearance were significantly longer in the ciprofol group compared to those in the propofol group (39.38 ± 8.57 s vs. 36.74 ± 6.82 s, P = 0.014 and 40.36 ± 8.59 s vs. 37.77 ± 6.84 s, P = 0.016, respectively). The adverse events incidence was significantly lower in the ciprofol group compared to that in the propofol group (25.47% vs. 89.62%, P = 0.000). The number of patients requiring top-up doses was not statistically significant (3.77% vs. 7.55%, P = 0.235). Ciprofol demonstrated advantages in hemodynamic stability and maintaining a better sedation level post-induction. Ciprofol was associated with a significantly lower incidence of hypotension compared to propofol (14.15% vs. 37.74%, P < 0.001), and more patients maintained appropriate sedation depth (86.80% vs. 72.64%, P = 0.010, 40 ≤ bispectral index ≤ 60 within 10 min of intravenous administration). Ciprofol offers a better sedative effect, fewer adverse events, and greater hemodynamic stability during general anesthesia induction in patients with obesity undergoing laparoscopic sleeve gastrectomy. ClinicalTrials.gov NCT05522998.

Based on finite element software DEFORM-3D, a three-dimensional oblique cutting model for aerospace aluminum alloy was built. The material's flow stress behavior was described with Johnson-Cook constitutive equation. The separation of the chips with the workpiece was realized by the combination of adaptive remeshing technique and separation criterion. The material's failure was defined by adopting Cockcroft & Latham fracture criterion. The tool-chip friction model was the combination of a Coulomb friction model and shear (sticking) friction model. To validate the finite element model, cutting tests were conducted. The effects of tool geometrical parameters such as flank wear, cutting edge inclination and corner radius on cutting forces were analyzed by three-dimensional oblique finite element model.

Transforming growth factor-β （TGF-β） binds with two transmembrane serine/threonine kinase receptors, type Ⅱ （TβRII） and type Ⅰ receptors （TβRⅠ）, and one accessory receptor, type Ⅲ receptor （TβRⅢ）, to transduce signals across cell membranes. Previous biochemical studies suggested that TβRI and TβRIII are preexisted homo-dimers. Using single-molecule microscopy to image green fluorescent protein-labeled membrane proteins, for the first time we have demonstrated that TβRI and TβRⅢ could exist as monomers at a low expression level. Upon TGF-β1 stimu- lation, TβRI follows the general ligand-induced receptor dimerization model for activation, but this process is TβRⅡ- dependent. The monomeric status of the non-kinase receptor TβRⅢ is unchanged in the presence of TGF-β1. With the increase of receptor expression, both TβRI and TβRIII can be assembled into dimers on cell surfaces.

Gas disasters always restrict the tunnel constructions in mountain area, which becomes a major geological barrier against the development of underground engineering. China is rich in coal resources and has a large amount of gas with a wide range of distribution. However, China experienced not only adverse effects on coal mining but also gas disasters in underground engineering construction, such as tunnels and chambers. With the increased number of tunnels passing through coal-bearing strata, the incidence of gas accidents is also rising. Therefore, the significance of preventing and mitigating gas disasters should be emphasized, and an effective risk assessment method for gas disasters should be established. On the basis of research on over 100 gas tunnels in China, a relatively ideal gas disaster risk assessment method and system for tunnels are established through the following measures. Firstly, geo-environmental conditions and gas situations were analyzed during construction. Secondly, qualitative analysis was combined with quantitative analysis. Finally, the influencing factors of gas disasters, including geological conditions, gas,and human factors, were investigated. The gas tunnel risk assessment system includes three levels：（1） the grading assessment of a gas tunnel during the planning stage,（2） the risk assessment of gas tunnel construction during the design and construction stages,（3） the gas tunnel outburst risk assessment during the coal uncovering stage. This system was applied to the dynamic assessment of gas disaster during the construction of the Zipingpu tunnel of Dujiangyan–Wenchuan Highway（in Sichuan, Southwest China）. The assessment results were consistent with the actual excavation, which verified the rationality and feasibility of the system. The developed system was believed to be back-up and applied for risk assessment of gas disaster in the underground engineering construction.

Studies on landslides by the 2008 Wenchuan earthquake showed that topography was of great importance in amplifying the seismic shaking, and among other factors, lithology and slope structure controlled the spatial occurrence of slope failures. The present study carried out experiments on four rock slopes with steep angle of 60°by means of a shaking table. The recorded Wenchuan earthquake waves were scaled to excite the model slopes. Measurements from accelerometers installed on free surface of the model slope were analyzed, with much effort on time-domain acceleration responses to horizontal components of seismic shaking. It was found that the amplification factor of peak horizontal acceleration, RPHA, was increasing with elevation of each model slope, though the upper and lower halves of the slope exhibited different increasing patterns. As excitation intensity was increased, the drastic deterioration of the inner structure of each slope caused the sudden increase of RPHA in the upper slope part. In addition, the model simulating the soft rock slope produced the larger RPHA than the model simulating the hard rock slope by a maximum factor of 2.6. The layered model slope also produced the larger RPHA than the homogeneous model slopeby a maximum factor of 2.7. The upper half of a slope was influenced more seriously by the effect of lithology, while the lower half was influenced more seriously by the effect of slope structure.

Traditional vegetation techniques for the control of concentrated flow erosion are widely recognized, whereas only a few studies have experimentally investigated the impacts of belowground roots on the erodibility of topsoils in semi-arid areas. To quantify the effects of root architectures on soil erodibility and its relevant structural properties, simulated flow experiments were conducted at six-week intervals from 18 July to 20 October in 2012 in the hilly Loess Plateau. Five treatments were： 1） bare （control）, 2） purple al- falfa （Medicago sativa）, representing tap roots （T）, 3） switchgrass （Panicum virgatum）, representing fibrous roots （F）, 4） purple alfalfa and switchgrass, representing both tap and fibrous roots （T ＋ F）, and 5） natural recovery （N）. For each treatment, soil structural proper- ties and root characteristics were measured at an interval of six weeks. Soil anti-scouribility was calculated. Results showed that grass planting slightly reduced soil bulk density, but increased soil aggregate content by 19.1%, 10.6%, 28.5%, and 41.2% in the treatments T, F, T ＋ F, and N, respectively. Soil shear strength （cohesion and angle of internal friction （φ）） significantly increased after the grass was planted. As roots grew, soil cohesion increased by 115.2%-135.5%, while soil disintegration rate decreased by 39.0%-58.1% in the 21th week compared with the recorded value in the 9th week. Meanwhile, root density and root surface area density increased by 64.0%-104.7% and 75.9%-157.1%, respectively. No significant differences in soil anti-scouribility were observed between the treat- ments of T and F or of T ＋ F and N, but the treatments of T ＋ F and N performed more effectively than T or F treatment alone in retard- ing concentrated flow. Soil aggregation and root surface-area density explained the observed soil anti-scouribility during concentrated flow well for the different treatments. This result proved that the restoration of natural vegetation might be the most appropriate strategy in soil reinforcement in the hilly Loess Plateau.

The wear and breakage features of TP1000 multi-coated tool were investigated through a series of cutting experiments. These experiments were performed for turning hardened 45 and T10A steel by orthogonal experimental method. SEM and XRD analysis were conducted on cutting tools. The results show that both wear and breakage occur when turning hardened 45 steel. The major wear mechanism is abrasion and oxidation, and the major breakage mechanism is surface spall. When turning hardened T10A steel, the main disability is breakage, and the major breakage mechanism include surface crack, spall and tipping.