Journal Article

Spatial epidemiological analysis based on township scale and analysis of influencing factors of pulmonary tuberculosis cure of Changshu city from 2015 to 2022

Zhou, Zheng-yuan, Gong, Li-qiang, Xu, Xiao-yan, Xu, Li-qiang, Jiao, Xiao-kang, Yin, Bian, Jiang, Tian-hong

2025

Overview

This study aimed to enhance the prevention and control of pulmonary tuberculosis (PTB) and provide more effective and accurate methods in Changshu City. The PTB patients' information came from the China Information System for Disease Control and Prevention (CISDCP). The demographic data for Changshu city and towns came from the Suzhou Statistical Yearbook and the LandScan platform. ArcGIS was used for global spatial autocorrelation analysis and local spatial autocorrelation analysis. Univariate logistic regression and multivariate logistic regression were used to analyze the influencing factors of cured PTB patients. The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to analyze the predictive efficacy and clinical benefit of the indicators. XGBoost analysis was performed to explore the feature importance of key metrics for PTB outcome. A total of 3943 PTB cases were included. The annual incidence rate of new PTB in Changshu city was 27.081 per 100,000. Changshu High-tech Industrial Development Zone in Jiangsu Province and Shajiabang town were the high-high aggregation areas and hot spot areas. Diagnosis delay, TB strain types, and drug sensitivity were independent predictors of the cure of new PTB patients. The central and southern areas of Changshu were the high-high cluster areas and hot spots for PTB. Shorter diagnosis delay days and mycobacterium tuberculosis (MTB) promote the cure of tuberculosis, while drug sensitivity was a risk factor for its cure.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / Aged / Antitubercular Agents - therapeutic use / Autocorrelation / Biology and Life Sciences / Care and treatment / China - epidemiology / Computer and Information Sciences / Developing countries / Diagnosis / Disease control / Disease hot spots / Disease prevention / Distribution / Earth Sciences / Effectiveness / Epidemiology / Female / Humans / Incidence / Industrial development / Infectious diseases / Information systems / LDCs / Logistic Models / Male / Medical referrals / Medicine and Health Sciences / Middle Aged / Multivariate analysis / Mycobacterium tuberculosis - drug effects / Patients / Population / Prevention / Pulmonary tuberculosis / Regression analysis / Risk Factors / ROC Curve / Social Sciences / Spatial Analysis / Statistical analysis / Tuberculosis / Tuberculosis, Pulmonary - diagnosis / Tuberculosis, Pulmonary - drug therapy / Tuberculosis, Pulmonary - epidemiology / Young Adult