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The learner model's design is a most important aspect of a personalized college student education recommendation system. Currently, most learner models need more scientific focus, relying on a single method to collect dimensions and feature attributes with low computing costs. Hence, this paper introduced a Multivariate Hybrid Criteria Fuzzy Algorithm (MHCFA) for personalized college education recommendation. The MHCFA is trained by Social Feedback Artificial Tree (SFAT), where SFAT is the combination of Social Optimization Algorithm (SOA) and Feedback Artificial Tree (FAT). In addition, Deep Fuzzy Clustering (DFC) is utilized to group college education content. The RV-Coefficient is employed to select the best content. Moreover, the feature is extracted by All Caps and numerical for further personalized recommendations. In addition, the test results show that SFATMHCFA performs better in Precision, Recall, and F-Measure where the values gained 0.989, 0.878, and 0.859, respectively.

The present study was conducted to estimate the effects of dietary carbohydrates on muscle quality and the underlying mechanisms. Six isonitrogenous and isolipidic diets were formulated to contain graded levels of carbohydrates (0%, 8%, 12%, 16%, 20% and 24%, respectively). These diets were named as C0, C8, C12, C16, C20 and C24, respectively. After a 10-week feeding trial, results showed that the muscle pH, liquid holding capacity (LHC) and hardness were significantly decreased by the increasing dietary carbohydrate levels. Dietary carbohydrates significantly decreased the muscle fibre diameter, and the highest value was found in the C0 group. Accumulated glycogen and degenerated mitochondrial cristae were observed in the C24 group. Significantly higher contents of protein carbonyls were observed in the C20 group and C24 group ( P  < 0.05). There was a significant decrease of mtDNA copy number in the C24 group compared with that in the C0 and C8 groups. The AMP/ATP ratio in muscle decreased first and then increased with the increasing dietary carbohydrate levels. The dietary incorporation of carbohydrate significantly reduced the expression of opa1 , pygm and genes involved in myogenesis ( myf5 and myog ). Meanwhile, proteolysis-related genes ( murf-1 , mafbx , capn2 and ctsl ), pro-inflammatory cytokines ( il-6 and tnf-α ) and mstn were significantly up-regulated. In the C24 group, significant increase of phosphorylation of AMPK (Thr172), up-regulation of PGC-1α and GLUT4 were observed, while the phosphorylation level of S6 (Ser235/236) was significantly decreased. It was concluded that excessive dietary carbohydrate level (24%) had negative impacts on mitochondria function and promoted glycogen accumulation, and thereafter influenced the muscle quality of olive flounder. The activation of AMPK as well as the upregulation of PGC-1α and GLUT4 was the key mechanism.

A global terrestrial stilling in recent decades has been reported, but the centennial-scale changes in global terrestrial near-surface wind speed (NSWS) and the potential contributing factors are yet to be revealed. Consequently, in this study, centennial-scale changes in global terrestrial NSWS are investigated based on Coupled Model Intercomparison Project phase 6 datasets, and that the potential factors causing those changes are detected. The results show that the global annual mean NSWS increased from 1850 to 1967 (+0.0045 m s −1 decade −1 , p < 0.01), with significant increases in North America, Europe, Africa, and South Asia. However, the NSWS decreased from 1968 to 2014 (−0.0044 m s −1 decade −1 , p < 0.01), significantly so in the mid-to-high latitudes of the Northern Hemisphere. The seasonal mean NSWS also increased before the 1960s and decreased thereafter. However, the NSWS over South America and most of Southern Africa increased during the study period. The changes in NSWS were caused mainly by changes in the number of strong windy days. The increase in NSWS from 1850 to 1967 could be attributed to internal variability, and the decrease in NSWS from 1968 to 2014 could be attributed to natural, aerosol, and greenhouse-gas forcings. However, internal variability acted mainly to increase the NSWS from 1968 to 2014, and so it is suggested that the contributions of external forcings to the global terrestrial stilling after the 1960s were considerable.

Carnivorous fish is thought to be high-glucose intolerance. But the reasons were still unclear. The aim of the present study is to investigate the effects of high level of dietary carbohydrate on the survival, growth and immune responses of Paralichthys olivaceus , and the underlying molecular mechanism related to the immune and glucose metabolism. P. olivaceus were fed with 8%, 16% and 24% of dietary carbohydrate for 10 weeks, respectively. After that, a glucose tolerance test (GTT) was conducted. Results showed that excessive (24%) dietary carbohydrate significantly decreased the growth and glucose tolerance ability according to the GTT. It significantly increased hepatic NADPH oxidase activity and malondialdehyde content and serum contents of IL-6 and advanced glycation end products. The expressions of glucose transport-relevant genes in liver and the content of related hormones in serum were analyzed. In conclusion, it was confirmed that IL-6 increased the expression of suppressor of cytokine signaling 3 ( SOCS3 ) and regulated the downstream targets of PI3K-AKT mediated signal transduction, and then downregulated the glucose transporter 2 activity in liver of P. olivaceus fed diet with excessive carbohydrate level. It was suggested that SOCS3 served as a bridge between immune response and glucose metabolism in P. olivaceus .

Employee creativity is essential for navigating digital disruption and maintaining organizational competitiveness; however, the mechanisms through which digital leadership fosters creativity remain underexplored. This study investigates the psychological and social processes through which digital leadership influences workplace creativity. Grounded in social cognitive and social exchange theories, the proposed model incorporates innovation self-efficacy and knowledge sharing as mediators and technology readiness as a moderator. Data were collected using a three-wave, time-lagged, multi-source survey design from 234 matched respondents, including employees and supervisors, across 20 business units in seven regional branches of a large Chinese organization undergoing digital transformation. The findings indicate that digital leadership significantly enhances employee creativity through the partial mediation of both innovation self-efficacy and knowledge sharing. Notably, the indirect effect through knowledge sharing was stronger, underscoring the critical role of collaborative processes in driving creativity. Furthermore, technology readiness positively moderates the effects of digital leadership on both mediators and amplifies the indirect effects on creativity. These findings provide valuable insights into how organizations can leverage digital leadership more effectively by aligning leadership strategies with employees’ psychological readiness and fostering a digitally supportive work environment.

Myocardial injury may be caused by myocardial ischemia-reperfusion (IR), and salvaging such an injury is still a great challenge in clinical practice. This study comprehensively characterized the physiopathologic changes of myocardial injury after IR to explore the underlying mechanism in the early reperfusion phase with particular emphasis on early myocardial inflammation. The experimental IR model was obtained by the left anterior descending artery's transient ligation of C57BL/6 mice. T2W signals of all mice showed increased signal at different IR stages. It was positively correlated with inflammatory cytokines and cells. T2W imaging by 7.0 T MRI surprisingly detected signal enhancement, but histopathology and flow cytometry did not reveal any inflammatory cells infiltration within 3 h after IR. Cardiomyocyte swelling and increased vascular permeability were observed by WGA staining and ultrastructural analysis, respectively. The 3 h IR group showed that the cardiomyocytes were severely affected with disintegrating myofilaments and mitochondria. Both VEGF and phosphorylated Src protein were markedly expressed in the 3 h IR group in comparison with the sham group, and TUNEL staining displayed little positive cells. Cleaved caspase-3 apoptin also has similar expression levels with that of the sham group. Resident macrophages had notably become M1 phenotype. The T2W signal was still elevated, and we observed that collagen deposition occurred from 1 to 7 days. The inflammation response during the first week after reperfusion injury gradually increase 3 h later, but the main manifestation before that was edema. This study indicated that the first 3 h may be crucial to the early rescue process for reperfusion-induced myocardial injury due to inflammatory cell infiltration absence and apoptosis.

Change points caused by extreme events in global economic markets have been widely studied in the literature. However, existing techniques to identify change points rely on subjective judgments and lack robust methodologies. The objective of this paper is to generalize a novel approach that leverages topological data analysis (TDA) to extract topological features from time series data using persistent homology. In this approach, we use Taken’s embedding and sliding window techniques to transform the initial time series data into a high-dimensional topological space. Then, in this topological space, persistent homology is used to extract topological features which can give important information related to change points. As a case study, we analyzed 26 stocks over the last 12 years by using this method and found that there were two financial market volatility indicators derived from our method, denoted as L1 and L2. They serve as effective indicators of long-term and short-term financial market fluctuations, respectively. Moreover, significant differences are observed across markets in different regions and sectors by using these indicators. By setting a significance threshold of 98 % for the two indicators, we found that the detected change points correspond exactly to four major financial extreme events in the past twelve years: the intensification of the European debt crisis in 2011, Brexit in 2016, the outbreak of the COVID-19 pandemic in 2020, and the energy crisis triggered by the Russia–Ukraine war in 2022. Furthermore, benchmark comparisons with established univariate and multivariate CPD methods confirm that the TDA-based indicators consistently achieve superior F1 scores across different tolerance windows, particularly in capturing widely recognized consensus events.

In recent years, the development and utilization of water resources have imposed great impacts on hydrological characteristics and ecological environment. In this paper, methods based on stable isotopes were used to analyze the cumulative effect of water projects and urbanization on the hydrological cycle in Qingbaijiang River Basin. Isotope evidence shows that the hydrological processes affected by water regulation and urbanized runoff generation differentiate greatly from the natural state. The annual mean isotopic values follow an order of groundwater > rainwater > river water. Consistent isotopic composition and variation trend between the near-bank groundwater and river water were only observed from May to late June 2018 and from February to April 2019 in the upper zone, indicating the dominant recharge of river to the groundwater. However, the isotopic variations between the two waters in the middle and lower zones suggested that the hydraulic exchange was limited, demonstrating the significant changes in river water level caused by the reservoir impoundment. The isotopic enrichment rate along the flow path is highest in January (0.0265‰/km), followed by October (0.0160‰/km), indicating the significant evaporation, while slight spatial changes in July (0.0027‰/km) reflected masked evaporation effect. This variability can be mainly attributed to the flow rate change and increase of water salinity in anthropic zones. Periodic regression analysis was employed to evaluate the difference in rainfall-runoff responses between hydrographic zones and estimate the mean residence time (MRT). Periodicity of isotopes in river water increased from upper to lower reaches with increasing R 2 values from 0.04 in SW1 to 0.46 in SW8. The MRT grew shorter along the flow path from 870 days in SW1 to 293 days in SW8, reflecting accelerated rainfall-runoff process due to the increasing impervious surface area and drainage system. These results identify the sensitivity of stable isotopes to the land use changes, runoff generation, and topography, and have implication for the potential water and environmental risks. Based on these understandings, suggestions for sustainable water-environment management in urban and rural areas were proposed.

Deep groundwater is buried thousands of meters underground and differs from shallow groundwater because it is characterized by high geothermal temperatures and high porewater pressures. In most situations, it also has high total dissolved solids (TDS) concentration. These characteristics affect the physical properties and movement of deep groundwater. This study analyzes the effects of matrix permeability, fluid density and dynamic viscosity on the estimation of hydraulic conductivity (K) by developing a semiempirical formula to calculate the K of deep water-bearing layers (WBLs). The ion interaction approach and Eyring’s semiempirical viscosity equation were used to calculate the density and dynamic viscosity of an ionic aqueous solution in a stratum. Then, the relationships between permeability, temperature, and pressure were deduced from equations related to geologic parameters. Accordingly, a semiempirical formula that considers high geothermal temperature, high TDS concentration, and high porewater pressure of deep groundwater was obtained. For verification, the semiempirical formula was used to calculate the K values collected from a 2,000-m-deep WBL, which was obtained during an injection test based on the Theis formula. The results of both calculation methods were approximate. Furthermore, the K value obtained by the semiempirical formula was quite close to that obtained from laboratory experiments based on Darcy’s Law. The good agreement between the two comparison cases demonstrates that using the semiempirical formula to estimate the K of deep WBLs is feasible and inexpensive.

In mammals, forkhead box O3 ( foxo3 ) plays important roles in liver immune system. The foxo3 can regulate cell cycle, DNA repair, hypoxia, apoptosis and so on. However, as such an important transcription factor, few studies on foxo3 in fish have been reported. The present study characterized the foxo3 in turbot ( Scophthalmus maximus L.). Lipopolysaccharide (LPS) incubated in vitro (hepatocytes) and injected in vivo (turbot liver) were used to construct inflammatory models. The foxo3 was interfered and overexpressed to investigate its functions in liver inflammation. The open reading frame (ORF) of foxo3 was 1998 bp (base pair), encoding 665 amino acids. Sequence analysis showed that foxo3 of turbot was highly homologous to other fishes. Tissue distribution analysis revealed that the highest expression of foxo3 was in muscle. Immunofluorescence result showed that foxo3 was expressed in cytoplasm and nucleus. Knockdown of foxo3 significantly increased mRNA levels of tumor necrosis factor-α ( tnf-α ), interleukin-1β ( il-1β) , interleukin-6 ( il-6) , myeloid-differentiation factor 88 ( myd88) , cd83 , toll-like receptor 2 ( tlr-2) and protein level of c-Jun N-terminal kinase (JNK) in si foxo3 + LPS (siRNA of foxo3 + LPS) group compared with NC + LPS (negative control + LPS) group in turbot hepatocytes. Overexpressed foxo3 significantly decreased mRNA levels of tnf-α , il-6 , nuclear transcription factor-kappa B ( nf-κb) , cd83 , tlr-2 and the protein level of JNK in vitro . In vivo analysis, foxo3 knockdown significantly increased levels of GOT in serum after LPS injection compared with NC+LPS group. Overexpressed foxo3 significantly decreased levels of GPT and GOT in pcDNA3.1- foxo3 +LPS group compared with pcDNA3.1+LPS group in vivo . Foxo3 knockdown significantly increased mRNA levels of tnf-α , il-1β , il-6 , nf-κb , myd88 and protein level of JNK in vivo in si foxo3 +LPS group compared with NC+LPS group in turbot liver. Overexpressed foxo3 significantly decreased mRNA levels of il-1β , il-6 , myd88 , cd83, jnk and protein level of JNK in pcDNA3.1- foxo3 +LPS group compared with pcDNA3.1+LPS group in turbot liver. The results indicated that foxo3 might modulate LPS-activated hepatic inflammation in turbot by decreasing the proinflammatory cytokines, the levels of GOT and GPT as well as activating JNK/caspase-3 and tlr-2/myd88/nf-κb pathways. Taken together, these findings indicated that FoxO3 may play important roles in liver immune responses to LPS in turbot and the research of FoxO3 in liver immunity enriches the studies on immune regulation, and provides theoretical basis and molecular targets for solving liver inflammation and liver injury in fish.