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The over-reliance on fossil fuels has led to severe pollution issues, prompting the development of renewable energy sources. Hydrogen energy, with its abundant reserves and environmentally friendly byproducts, is a promising alternative. Efficient and safe HS is crucial for its widespread application. This review analyzes several HS methods and materials, focusing on their principles, performance, advantages, and disadvantages. The storage of high-pressure gaseous hydrogen is mature and low-cost but has low density and safety risks. Low-temperature liquid HS offers higher density but involves significant energy consumption and costs. Solid-state hydrogen storage (SHS), including carbon materials, metal-organic frameworks (MOFs), and metal hydride material, shows potential for high density and purity but faces challenges in material costs and performance. The paper highlights advancements in activated carbon, graphene, carbon nanotubes, MOFs, and Mg-based and Ti-based metal hydrides. It discusses the progress and challenges in improving HS capacities, stability, and costeffectiveness. Future research will focus on increasing HS density, reducing costs, and enhancing safety through interdisciplinary collaboration. This review provides insights into the current state and future directions of HS technologies, essential for advancing the hydrogen economy and achieving sustainable energy solutions.

This paper reviews the wide range of applications and current research status of metamaterials in the biomedical field, demonstrating their great potential in enhancing diagnostic accuracy, promoting tissue regeneration, and treating diseases. This paper reviews the wide range of applications and current research status of metamaterials in the biomedical field, demonstrating their great potential in enhancing diagnostic accuracy, promoting tissue regeneration, and treating diseases. performance of traditional materials, metamaterials have made remarkable progress in the biomedical field by virtue of their unique physical properties and high designability. In the case of terahertz metamaterials, precise detection of biomolecules and tissues has been achieved by combining their high sensitivity with their high designability. In the case of terahertz metamaterials, precise detection of biomolecules and tissues has been achieved by combining their high sensitivity with the high penetrability of biological tissues. Mechanical metamaterials, on the other hand, promote the sensitivity enhancement of flexible strain sensors and the advancement of tissue engineering by simulating the mechanical behavior of biological tissues. In addition, multifunctional metamaterials such as light-driven, thermally-driven, magnetic, chiral, and electrically-driven have opened up new possibilities in the biotechnology industry. In addition, multifunctional metamaterials such as light-driven, thermally-driven, magnetic, chiral, and electrically-driven have opened up new possibilities in the biomedical field. Despite the challenges of biocompatibility and control of material degradation rate, metamaterials are still promising for applications in disease diagnosis, treatment, and drug discovery. Future research should focus on improving material biocompatibility, developing advanced manufacturing technologies, promoting personalized medicine, and strengthening Future research should focus on improving material biocompatibility, developing advanced manufacturing technologies, promoting personalized medicine, and strengthening interdisciplinary collaborations to further explore the potential of metamaterials in biomedicine.

Myocardial injury induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reportedly related to disease severity and mortality, attracting attention to exploring relevant pathogenic mechanisms. Limited by insufficient evidence, myocardial injury caused by direct viral invasion of cardiomyocytes (CMs) is not fully understood. Based on recent studies, endosomal dependence can compensate for S protein priming to mediate SARS-CoV-2 infection of CMs, damage the contractile function of CMs, trigger electrical dysfunction, and tip the balance of the renin–angiotensin–aldosterone system to exert a myocardial injury effect. In this review, we shed light on the direct injury caused by SARS-CoV-2 to provide a comprehensive understanding of the cardiac manifestations of coronavirus disease 2019 (COVID-19).

Background Pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) is recognized as a cancer-like disease with a proliferative and pro-migratory phenotype in pulmonary artery smooth muscle cells (PASMCs). Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) has been implicated in the progression of various cancers; however, it has not been previously studied in the context of CHD-PAH. Here, we aimed to examine the function of CacyBP/SIP in CHD-PAH and explore its potential as a novel regulatory target for the disease. Methods The expression of CacyBP/SIP in PASMCs was evaluated both in the pulmonary arterioles of patients with CHD-PAH and in high-flow-induced PAH rats. The effects of CacyBP/SIP on pulmonary vascular remodeling and PASMC phenotypic switch, proliferation, and migration were investigated. LY294002 (MedChemExpress, NJ, USA) was used to block the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway to explore changes in PASMC dysfunction induced by low CacyBP/SIP levels. Hemodynamics and pulmonary arterial remodeling were further explored in rats after short-interfering RNA-mediated decrease of CacyBP/SIP expression. Results CacyBP/SIP expression was markedly reduced both in the remodeled pulmonary arterioles of patients with CHD-PAH and in high-flow-induced PAH rats. Low CacyBP/SIP expression promoted hPASMC phenotypic switch, proliferation, and migration via PI3K/AKT pathway activation. Our results indicated that CacyBP/SIP protected against pulmonary vascular remodeling through amelioration of hPASMC dysfunction in CHD-PAH. Moreover, after inhibition of CacyBP/SIP expression in vivo, we observed increased right ventricular hypertrophy index, poor hemodynamics, and severe vascular remodeling. Conclusions CacyBP/SIP regulates hPASMC dysfunction, and its increased expression may ameliorate progression of CHD-PAH.

Chinese goldthread ( Coptis chinensis Franch.), a member of the Ranunculales, represents an important early-diverging eudicot lineage with diverse medicinal applications. Here, we present a high-quality chromosome-scale genome assembly and annotation of C. chinensis . Phylogenetic and comparative genomic analyses reveal the phylogenetic placement of this species and identify a single round of ancient whole-genome duplication (WGD) shared by the Ranunculaceae. We characterize genes involved in the biosynthesis of protoberberine-type alkaloids in C. chinensis . In particular, local genomic tandem duplications contribute to member amplification of a Ranunculales clade-specific gene family of the cytochrome P450 (CYP) 719. The functional versatility of a key CYP719 gene that encodes the ( S )-canadine synthase enzyme involved in the berberine biosynthesis pathway may play critical roles in the diversification of other berberine-related alkaloids in C. chinensis . Our study provides insights into the genomic landscape of early-diverging eudicots and provides a valuable model genome for genetic and applied studies of Ranunculales. Coptis chinensis represents an early-diverging eudicot lineage with diverse medicinal applications. Here, the authors report its chromosome-scale genome assembly, infer a single ancient whole-genome duplication, and characterize the function of CYP719 in diversification of protoberberine-type alkaloids.

We used metagenomic analysis to identify Tacheng tick virus 2 infection in a patient with a history of tick bite in northwestern China. We confirmed the virus with reverse transcription-PCR, virus isolation, and genomic analysis. We detected viral RNA in 9.6% of ticks collected from the same region.

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has spread rapidly across the world and become an international public health emergency. Both SARS-CoV-2 and SARS-CoV belong to subfamily Coronavirinae in the family Coronaviridae of the order Nidovirales and they are classified as the SARS-like species while belong to different cluster. Besides, viral structure, epidemiology characteristics and pathological characteristics are also different. We present a comprehensive survey of the latest coronavirus—SARS-CoV-2—from investigating its origin and evolution alongside SARS-CoV. Meanwhile, pathogenesis, cardiovascular disease in COVID-19 patients, myocardial injury and venous thromboembolism induced by SARS-CoV-2 as well as the treatment methods are summarized in this review.

Background LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer. Methods TCGA database was used to analyze the abnormal expression of lncRNA PCED1B-AS1 in gastric cancer. By database prediction and mass spectrometric analysis, miR-3681-3p and MAP2K7 are potential downstream target molecules of lncRNA PCED1B-AS1 and verified by dual-luciferase report assay. RT- q PCR analysis and western blot were performed to detect the expressions of PCED1B-AS1 and MAP2K7 in gastric cancer cell lines and tissues. CCK-8 kit was applied to measure the cell viability. Wound healing and Transwell experiment were used to detect the migration and invasion. Western blot and immunohistochemical staining were performed to detect the expressions of EMT-related proteins in tissues. The changes of tumor proliferation were detected by xenograft experiment in nude mice. Results PCED1B-AS1 expression was higher but miR-3681-3 expression was lower in gastric cancer cell lines or tissues, compared to normal group. Function analysis verified PCED1B-AS1 promoted cell proliferation and inhibited cell apoptosis in gastric cancer cells in vitro and in vivo. LncRNA PCED1B-AS1 could bind directly to miR-3681-3p, and MAP2K7 was found to be a downstream target of miR-3681-3p. MiR-3681-3p mimics or si-MAP2K7 could partly reverse the effect of PCED1B-AS1 on gastric cancer cells. Conclusion PCED1B-AS1 accelerated cell proliferation and inhibited cell apoptosis through sponging miR-3681-3p to upregulate MAP2K7 expression in gastric cancer, which indicated PCED1B-AS1/miR-3681-3p/MAP2K7 axis may serve as a potential therapeutic target for gastric cancer.

The urban open public spaces are the areas where people tend to gather together, which may lead to great crowd-gathering risk. This paper proposes a new method to assess the rank and spatial distribution of crowd-gathering risk in open public spaces in a large urban area. Firstly, a crowd density estimation method based on Tencent user density (TUD) data is built for different times in open public spaces. Then, a reasonable crowd density threshold is delimited to detect critical crowd situations in open public spaces and find out the key open public spaces that need to have intensive crowd-gathering prevention. For estimating the crowd-gathering risk in key open public spaces, the quantified risk assessment approach is conducted based on the classical risk theory that simultaneously considers the probability of an accident occurring, the severity of the accident consequence, and the risk aversion factor. A case study of the area within the Outer-ring Road of Shanghai was conducted to determine the feasibility of the new method. The thematic maps that describe the ranks and spatial distribution of crowd-gathering risk were generated. According to the risk maps, the government can determine the crowd control measures in different areas to reduce the crowd-gathering risk and prevent dangerous events.

Given its special geographical location and size, Shanghai is a key hub linking world and locality, in this case China, in the implementation of anti-Covid-19 measures. By coordinating all the work according to the rule of law, Shanghai has outlined the basic framework for fighting the epidemic; by establishing the community grid governance model, Shanghai has soundly harnessed the ‘political potential energy’ and effectively filled in the internal mechanism of anti-Covid-19 and urban governance; and by respecting professionalism and the role of the masses, Shanghai seized the best opportunity to fight against the epidemic. Therefore, Shanghai has built up public value and gained spiritual support to fight against the epidemic and fundamentally improved the governance efficiency of the city. The experience of Shanghai’s anti-epidemic measures and governance forms an organic whole through mutual embedding and ultimately relies on efficient and fair governance.