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Fast radio bursts (FRBs) are millisecond-duration radio transients 1 , 2 of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star magnetospheres 3 – 5 or relativistic shocks far from the central energy source 6 – 8 . Detailed polarization observations may help us to understand the emission mechanism. However, the available FRB polarization data have been perplexing, because they show a host of polarimetric properties, including either a constant polarization angle during each burst for some repeaters 9 , 10 or variable polarization angles in some other apparently one-off events 11 , 12 . Here we report observations of 15 bursts from FRB 180301 and find various polarization angle swings in seven of them. The diversity of the polarization angle features of these bursts is consistent with a magnetospheric origin of the radio emission, and disfavours the radiation models invoking relativistic shocks. Polarization observations of the fast radio burst FRB 180301 with the FAST radio telescope show diverse polarization angle swings, consistent with a magnetospheric origin of the emission.

Objective To investigate the correlation between bone metabolism markers, bone mineral density (BMD), and sarcopenia. Methods A total of 331 consecutive patients aged ≥ 60 years who were hospitalized between November 2020 and December 2021 were enrolled. Participants were divided into sarcopenia and non-sarcopenia groups according to the Asian Working Group on Sarcopenia criteria (AWGS, 2019). The clinical data, bone metabolism markers (β-CTX, N-MID, and TP1NP), and BMD were compared between the two groups. Results Age, β-CTX, and N-MID of the sarcopenia group were higher than those of the non-sarcopenia group ( P  < 0.05), but the BMD T values were lower than those of the non-sarcopenia group ( P  < 0.05). Binary logistic regression analysis showed that increased femoral neck BMD (FNBMD) was a protective factor for sarcopenia, while increased β-CTX was a risk factor. Pearson/Spearman correlation analysis showed that the diagnostic indices of sarcopenia were positively correlated with FNBMD and negatively correlated with β-CTX and N-MID. Multiple linear regression analysis revealed that BMI and FNBMD significantly positively affected muscle strength and appendicular skeletal muscle mass (ASM). The FNBMD significantly positively affected physical performance, while β-CTX significantly negatively affected muscle strength, ASM, and physical performance. Conclusion Increased FNBMD may be a protective factor against sarcopenia, and increased β-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while β-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia.

PurposeThe purpose of this paper is to propose a unified optimization design method and apply it to handle the brake squeal instability involving various uncertainties in a unified framework.Design/methodology/approachFuzzy random variables are taken as equivalent variables of conventional uncertain variables, and a unified response analysis method is first derived based on level-cut technique, Taylor expansion and central difference scheme. Next, a unified reliability analysis method is developed by integrating the unified response analysis and fuzzy possibility theory. Finally, based on the unified reliability analysis method, a unified reliability-based optimization model is established, which is capable of optimizing uncertain responses in a unified way for different uncertainty cases.FindingsThe proposed method is extended to perform squeal instability analysis and optimization involving various uncertainties. Numerical examples under eight uncertainty cases are provided and the results demonstrate the effectiveness of the proposed method.Originality/valueMost of the existing methods of uncertainty analysis and optimization are merely effective in tackling one uncertainty case. The proposed method is able to handle the uncertain problems involving various types of uncertainties in a unified way.

Sterile inflammation after myocardial infarction is classically credited to myeloid cells interacting with dead cell debris in the infarct zone 1 , 2 . Here we show that cardiomyocytes are the dominant initiators of a previously undescribed type I interferon response in the infarct borderzone. Using spatial transcriptomics analysis in mice and humans, we find that myocardial infarction induces colonies of interferon-induced cells (IFNICs) expressing interferon-stimulated genes decorating the borderzone, where cardiomyocytes experience mechanical stress, nuclear rupture and escape of chromosomal DNA. Cardiomyocyte-selective deletion of Irf3 abrogated IFNIC colonies, whereas mice lacking Irf3 in fibroblasts, macrophages, neutrophils or endothelial cells, Ccr2 -deficient mice or plasmacytoid-dendritic-cell-depleted mice did not. Interferons blunted the protective matricellular programs and contractile function of borderzone fibroblasts, and increased vulnerability to pathological remodelling. In mice that died after myocardial infarction, IFNIC colonies were immediately adjacent to sites of ventricular rupture, while mice lacking IFNICs were protected from rupture and exhibited improved survival 3 . Together, these results reveal a pathological borderzone niche characterized by a cardiomyocyte-initiated innate immune response. We suggest that selective inhibition of IRF3 activation in non-immune cells could limit ischaemic cardiomyopathy while avoiding broad immunosuppression. Cardiomyocytes are the dominant initiators of a type I interferon response in the infarct borderzone.

Summary The frequency–temperature characteristics of quartz crystal resonators, particularly the frequency stability in a specific temperature range in which the vibration modes are strongly coupled, has been an important requirement in most applications. The analytical work on frequency–temperature relations has been done over the last decades in many aspects, ranging from the fundamental theory for the thermal effect on vibrations of elastic solids to simplified plate equations of a few strongly coupled vibration modes. However, it has been clearly observed that due to complications of the resonator structures such as the presence of a mounting structure and electrodes, simple and analytical solutions will not be able to consider all the factors which will have inevitable and noticeable effects. In this paper, we incorporate the frequency–temperature theory for crystal plates based on the incremental thermal field formulation by Lee and Yong into our finite element analysis implementation, which is then used to analyze the free vibrations of crystal plates with the higher-order Mindlin plate theory. The effect of electrodes on the frequency–temperature relation is also considered. The computational results are compared with experimental ones from actual products. The satisfactory agreement demonstrates the precise prediction of the frequency–temperature behavior and practical applications of the finite element analysis in product modeling and development.

Purpose This paper aims to develop an efficient numerical method for mid-frequency analysis of built-up structures with large convex uncertainties. Design/methodology/approach Based on the Chebyshev polynomial approximation technique, a Chebyshev convex method (CCM) combined with the hybrid finite element/statistical energy analysis (FE-SEA) framework is proposed to fulfil the purpose. In CCM, the Chebyshev polynomials for approximating the response functions of built-up structures are constructed over the uncertain domain by using the marginal intervals of convex parameters; the bounds of the response functions are calculated by applying the convex Monte–Carlo simulation to the approximate functions. A relative improvement method is introduced to evaluate the truncated order of CCM. Findings CCM has an advantage in accuracy over CPM when the considered order is the same. Furthermore, it is readily to consider the CCM with the higher order terms of the Chebyshev polynomials for handling the larger convex parametric uncertainty, and the truncated order can be effectively evaluated by the relative improvement method. Originality/value The proposed CCM combined with FE-SEA is the first endeavor to efficiently handling large convex uncertainty in mid-frequency vibro-acoustic analysis of built-up structures. It also has the potential to serve as a powerful tool for other kinds of system analysis when large convex uncertainty is involved.

The shear flow influences the stability of magnetohydrodynamic (MHD) waves. In the presence of a dissipation mechanism, flow shear may induce a MHD wave instability below the threshold of the Kelvin-Helmholtz instability (KHI), which is called dissipative instability (DI). This phenomenon is also called negative energy wave instability (NEWI) because it is closely related to the backward wave which has negative wave energy. Considering viscosity as a dissipation mechanism, we derive an analytical dispersion relation for the slow sausage modes in a straight cylinder with a discontinuous boundary. It is assumed that the steady flow is inside and dynamic and bulk viscosities are outside the circular flux tube under photospheric condition. When the two viscosities are weak, it is found that for the slow surface mode, the growth rate is proportional to the axial wavenumber and flow shear, consistent with in the incompressible limit. For a slow body mode, the growth rate has a peak at certain axial wavenumber and its order of magnitude is similar to surface mode. The linear relationship between the growth rate and the dynamic viscosity established in the incompressible limit develops nonlinearly when the flow shear and/or the two viscosities are sufficiently strong.

We investigate the propagation of MHD fast waves into a cylindrical coronal loop through an inhomogeneous stationary flow region. The background flow is assumed to have a small, spatially periodic structure in addition to a constant speed. We focus on the absorption of the wave energy in Alfv\\'{e}n resonance, comparing with the constant flow case. A new flow (absorption) regime is induced by the periodic flow structure which enhances the absorption for the antiparallel flow and inverse absorption (overreflection) for the parallel flow with respect to the axial wave vector, depending on the transitional layer and flow profiles. A giant overreflection and anomalous absorption behavior arise for some flow configurations. In the other flow regimes, its effect on the absorption is shown to be weak.