Explore the vast range of titles available.

The traditional approach to e-commerce marketing encounters challenges in effectively extracting and utilizing user data, as well as analyzing and targeting specific user segments. This manuscript aims to address these limitations by proposing the establishment of a consumer behavior analysis system based on an Internet of Things (IoT) platform. The system harnesses the potential of radio frequency identification devices (RFID) technology for product identification encoding, thus facilitating the monitoring of product sales processes. To categorize consumers, the system incorporates a k-means algorithm within its architectural framework. Furthermore, a similarity metric is employed to evaluate the gathered consumption information and refine the selection strategy for initial clustering centers. The proposed methodology is subjected to rigorous testing, revealing its effectiveness in resolving the issue of insufficient differentiation between customer categories after clustering. Across varying values of k, the average false recognition rate experiences a notable reduction of 20.6%. The system consistently demonstrates rapid throughput and minimal overall latency, boasting an impressive processing time of merely 2 ms, thereby signifying its exceptional concurrent processing capability. Through the implementation of the proposed system, the opportunity for further target market segmentation arises, enabling the establishment of core market positioning and the formulation of distinct and precise marketing strategies tailored to diverse consumer cohorts. This pioneering approach introduces an innovative and efficient methodology that e-commerce enterprises can embrace to amplify their marketing endeavors.

Necroptosis and ferroptosis are two distinct necrotic cell death modalities with no known common molecular mechanisms. Necroptosis is activated by ligands of death receptors such as tumor necrosis factor-α (TNF-α) under caspase-deficient conditions, whereas ferroptosis is mediated by the accumulation of lipid peroxides upon the depletion/or inhibition of glutathione peroxidase 4 (GPX4). The molecular mechanism that mediates the execution of ferroptosis remains unclear. In this study, we identified 2-amino-5-chloro-N,3-dimethylbenzamide (CDDO), a compound known to inhibit heat shock protein 90 (HSP90), as an inhibitor of necroptosis that could also inhibit ferroptosis. We found that HSP90 defined a common regulatory nodal between necroptosis and ferroptosis. We showed that inhibition of HSP90 by CDDO blocked necroptosis by inhibiting the activation of RIPK1 kinase. Furthermore, we showed that the activation of ferroptosis by erastin increased the levels of lysosome-associated membrane protein 2a to promote chaperone-mediated autophagy (CMA), which, in turn, promoted the degradation of GPX4. Importantly, inhibition of CMA stabilized GPX4 and reduced ferroptosis. Our results suggest that activation of CMA is involved in the execution of ferroptosis.

Improving the accessibility of ions in the electrodes of electrochemical energy storage devices is vital for charge storage and rate performance. In particular, the kinetics of ion transport in organic electrolytes is slow, especially at low operating temperatures. Herein, we report a new type of MXene-carbon nanotube (CNT) composite electrode that maximizes ion accessibility resulting in exceptional rate performance at low temperatures. The improved ion transport at low temperatures is made possible by breaking the conventional horizontal alignment of the two-dimensional layers of the MXene Ti 3 C 2 by using specially designed knotted CNTs. The large, knot-like structures in the knotted CNTs prevent the usual restacking of the Ti 3 C 2 flakes and create fast ion transport pathways. The MXene-knotted CNT composite electrodes achieve high capacitance (up to 130 F g −1 (276 F cm −3 )) in organic electrolytes with high capacitance retention over a wide scan rate range of 10 mV s −1 to 10 V s −1 . This study is also the first report utilizing MXene-based supercapacitors at low temperatures (down to −60 °C). Improving the accessibility of ions in the electrodes of electrochemical energy storage devices is vital for charge storage and rate performance. Here, the authors report a new type of MXene-carbon nanotube composite electrode that maximizes ion accessibility, resulting in high rate performance at low temperatures.

Cancer is a major factor threatening human health and life safety, and there is a lack of safe and effective therapeutic drugs. Intervention and prevention in premalignant process are effective ways to reverse carcinogenesis and prevent cancer from occurring. Plant natural products are rich in sources and are a promising source for cancer chemoprevention. This article reviews the chemopreventive effects of natural products, especially focused on polyphenols, flavonoids, monoterpene and triterpenoids, sulfur compounds, and cellulose. Meanwhile, the main mechanisms include induction of apoptosis, antiproliferation and inhibition of metastasis are briefly summarized. In conclusion, this article provides evidence for natural products remaining a prominent source of cancer chemoprevention.

Few-layer black phosphorus (BP) with an anisotropic two-dimensional (2D)-layered structure shows potential applications in photoelectric conversion and photocatalysis, but is easily oxidized under ambient condition preferentially at its edge sites. Improving the ambient stability of BP nanosheets has been fulfilled by chemical functionalization, however this functionalization is typically non-selective. Here we show that edge-selective functionalization of BP nanosheets by covalently bonding stable C 60 molecules leads to its significant stability improvement. Owing to the high stability of the hydrophobic C 60 molecule, C 60 functions as a sacrificial shield and effectively protects BP nanosheets from oxidation under ambient condition. C 60 bonding leads to a rapid photoinduced electron transfer from BP to C 60 , affording enhanced photoelectrochemical and photocatalytic activities. The selective passivation of the reactive edge sites of BP nanosheets by sacrificial C 60 molecules paves the way toward ambient processing and applications of BP. Few-layered black phosphorus has unique and appealing electronic properties but is easily oxidized in air. Here, the authors covalently functionalize black phosphorus nanosheets with C 60 at their edges, providing improved stability and enhanced photoelectrochemical and photocatalytic activities.

The immune index is an important marker of HIV immune function. Long-term clinical experience revealed that in urinary malignancy patients with AIDS who underwent radical surgery for malignant tumors, the preoperative and postoperative immune indices changed to different degrees, which affected patient prognosis. A total of 48 AIDS patients who underwent radical resection of malignant tumors in the Department of Urology of Beijing You ‘an Hospital between 2015 and 2023 were included, including 25 patients with kidney cancer, 12 patients with bladder cancer and 11 patients with prostate cancer. A paired t test was used to study the changes in the immune indices CD4 + T, CD8 + T, CD3 + T and CD4+/CD8 + T cells before and after surgery for different malignant tumors in the urinary tract. The chi-square test was used to study the effects of clinical variables such as age, sex, hypertension status, diabetes status, duration of operation, duration of HIV infection, duration of medication and viral load on preoperative and postoperative immune indices. The area under the ROC curve of the four immune indicators before and after surgery was compared to evaluate the influence of immune indicators on patient prognosis. Survival curves were drawn to study the prognostic risk of immune indicators. The mean CD4 + T, CD8 + T and CD3 + T-cell counts decreased before and after surgery in patients with renal, bladder and prostate cancer, and P < 0.05 according to paired t tests indicated statistical significance, while the CD4+/CD8 + T-cell ratio was not significantly different according to paired t tests. Clinical variables such as age, sex, hypertension status, diabetes status, duration of operation, duration of HIV infection, duration of medication and viral load had no statistically significant effects on the preoperative or postoperative immune indices. The area under the ROC curve of the four immune indices was compared, and the results showed that CD8 + T cells [preoperative AUC of 0.678 (P < 0.05) and postoperative AUC of 0.702 (P < 0.05)] were superior to the other indices. Survival curve analysis revealed that a decrease in CD4 + T, CD8 + T and CD3 + T cells after surgery led to a decrease in the survival rate of patients, but the results were not statistically significant. CD4 + T, CD8 + T and CD3 + T cells decreased before and after surgery in patients with malignant tumors of the urinary system complicated with AIDS, and CD8 + T cells had a statistically significant effect on patient prognosis compared with other immune indices.

Zanthoxylum bungeanum Maxim. (Rutaceae) is a popular food additive and traditional Chinese herbal medicine commonly named HuaJiao in China. This plant is widely distributed in Asian countries. The aim of this paper is to provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of this plant. Furthermore, the possible development and perspectives for future research on this plant are also discussed. To date, over 140 compounds have been isolated and identified from Z. bungeanum, including alkaloids, terpenoids, flavonoids, and free fatty acids. The extracts and compounds have been shown to possess wide-ranging biological activity, such as anti-inflammatory and analgesic effects, antioxidant and anti-tumor effects, antibacterial and antifungal effects, as well as regulatory effects on the gastrointestinal system and nervous system, and other effects. As a traditional herbal medicine, Z. bungeanum has been widely used to treat many diseases, especially digestive disorders, toothache, stomach ache, and diarrhea. Many traditional usages of this plant have been validated by present investigations. However, further research elucidating the structure-function relationship among chemical compounds, understanding the mechanism of unique sensation, as well as exploring new clinical effects and establishing criteria for quality control for Z. bungeanum should be further studied.

The reduction of carbon dioxide using electrochemical cells is an appealing technology to store renewable electricity in a chemical form. The preferential adsorption of oxygen over carbon atoms of intermediates could improve the methanol selectivity due to the retention of C–O bond. However, the adsorbent-surface interaction is mainly related to the d states of transition metals in catalysts, thus it is difficult to promote the formation of oxygen-bound intermediates without affecting the carbon affinity. This paper describes the construction of a molybdenum-based metal carbide catalyst that promotes the formation and adsorption of oxygen-bound intermediates, where the sp states in catalyst are enabled to participate in the bonding of intermediates. A high Faradaic efficiency of 80.4% for methanol is achieved at −1.1 V vs. the standard hydrogen electrode. While the reduction of CO 2 to specific products offers a valuable approach mitigating gas emissions, it is challenging to control the formation of crucial intermediates. Here, authors report a strategy to promote the formation of oxygen-bound intermediates and boost the methanol production.

Ferroferric oxide/polypyrrole (Fe 3 O 4 /PPy) composites were prepared by an in situ polymerization method. Several analysis techniques including X-ray diffraction, Fourier transform infrared spectra, thermogravimetric analysis and scanning electron microscopy are applied to analyze the structure and morphology of Fe 3 O 4 /PPy. The magnetic Fe 3 O 4 /PPy was further used as an adsorbent for removing Eosin Y, methyl orange and brilliant green from aqueous phase. The adsorption kinetics were investigated by pseudo-first-order, pseudo-second-order and intraparticle diffusion models, and the experimental data were well fitted to the pseudo-second order. The equilibrium adsorption data can be described by both the Langmuir and Freundlich isotherm models. The calculated Langmuir maximum adsorption capacities of Eosin Y, methyl orange and brilliant green at 25 °C are 212.31, 149.48 and 263.85 mg/g, respectively. Thermodynamic studies indicated that the adsorption process occurred spontaneously, in an endothermic and physisorption nature, and with increased disorder. Furthermore, the convenient magnetic separability of Fe 3 O 4 /PPy makes it a good candidate for practical application in the removal of organic dyes from polluted water.

OSCA/TMEM63 channels, which have transporter-like architectures, are bona fide mechanosensitive (MS) ion channels that sense high-threshold mechanical forces in eukaryotic cells. The activation mechanism of these transporter-like channels is not fully understood. Here we report cryo-EM structures of a dimeric OSCA/TMEM63 pore mutant OSCA1.1-F516A with a sequentially extracellular dilated pore in a detergent environment. These structures suggest that the extracellular pore sequential dilation resembles a flower blooming and couples to a sequential contraction of each monomer subunit towards the dimer interface and subsequent extrusion of the dimer interface lipids. Interestingly, while OSCA1.1-F516A remains non-conducting in the native lipid environment, it can be directly activated by lyso-phosphatidylcholine (Lyso-PC) with reduced single-channel conductance. Structural analysis of OSCA1.1-F516A in lyso-PC-free and lyso-PC-containing lipid nanodiscs indicates that lyso-PC induces intracellular pore dilation by attracting the M6b to upward movement away from the intracellular side thus extending the intracellular pore. Further functional studies indicate that full activation of MS OSCA/TMEM63 dimeric channels by high-threshold mechanical force also involves the opening of both intercellular and extracellular pores. Our results provide the fundamental activation paradigm of the unique transporter-like MS OSCA/TMEM63 channels, which is likely applicable to functional branches of the TMEM63/TMEM16/TMC superfamilies. How mechanosensitive OSCA/TMEM63 channels are activated remains a mystery. Here, the authors reveal the landscapes of the activation process of OSCA/TMEM63 channels.