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Using special commands in TCP/IP protocol family can realize the detection of network running status, and network managers must master the command group. This program integrating network managers＇ manual network test into a 24-hour operation procedure can simply find out network faults occurring, and the fault information can be sent to the mobile phone of a network manager in the form of a short message, so that the network manager can take fast and active measures as early as possible.

Ultra-fast cooling （UFC） is an advanced technology in hot rolling field. Through this technology, great changes on the run-out table are produced in the strip cooling process. In order to adapt to these changes, a new gen-eration of hot strip cooling control system after rolling was developed based on the UFC basic principle. The system can not only accomplish temperature of UFC delivery side, coiling temperature, cooling rate, etc, and multi-objective accuracy control, but also offer more flexibility and new attractive possibilities in terms of cooling pattern on the run-out table, which could be of prime importance for the production of some difficult steels. In addition, through the time-velocity-distance （TVD） profile prediction combined with speed feed-forward control and coiling temperature feedback control, the coiling temperature control precision can be effectively improved during accelerative rolling in the system. At present, the system has been successfully used in the conventional strip production line and CSP short process production line, and its application effect is perfect.

Si-based multilayer structures are widely used in current microelectronics. During their preparation, some inhomogeneous residual stress is induced, resulting in competition between interface mismatching and surface energy and even leading to structure failure. This work presents a methodological study on the measurement of residual stress in a multi-layer semiconductor heterostructure. Scanning electron microscopy (SEM), micro-Raman spectroscopy (MRS), and transmission electron microscopy (TEM) were applied to measure the geometric parameters of the multilayer structure. The relationship between the Raman spectrum and the stress/strain on the [100] and [110] crystal orientations was determined to enable surface and cross-section residual stress analyses, respectively. Based on the Raman mapping results, the distribution of residual stress along the depth of the multi-layer heterostructure was successfully obtained.

Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differenti- ated somatic cell into a multipotent state without first establishing pluripotency. Here, we demonstrate that sertoli cells derived from mesoderm can be directly converted into a multipotent state that possesses neural stem/progenitor cell properties. The induced neural stem/progenitor cells （iNSCs） express multiple NSC-specific markers, exhibit a global gene-expression profile similar to normal NSCs, and are capable of self-renewal and differentiating into glia and electrophysiologically functional neurons, iNSC-derived neurons stain positive for tyrosine hydroxylase （TH）, y-aminobutyric acid, and choline acetyltransferase. In addition, iNSCs can survive and generate synapses following transplantation into the dentate gyrus. Generation of iNSCs may have important implications for disease modeling and regenerative medicine.

Aim： Doxazosin is a racemic mixture of （–）doxazosin and （＋）doxazosin that is currently used as an add-on therapy for hypertension. In this study we investigated the contribution of each enantiomer to the hypotensive action of long-term administration of （±）doxazosin in conscious rats. Methods： Blood pressure of conscious SD rats was measured using a volume pressure recording system. The rats were orally administered （–）doxazosin, （＋）doxazosin, or （±）doxazosin （8 mg·kg-1·d-1） for 12 weeks. Plasma concentrations of the agents were analyzed with HPLC. The effect of the agents on α1-adrenoceptor was examined in isolated rat caudal artery preparations. Results： Treatment of conscious rats with a single dose of （±）doxazosin （8 mg/kg） did not affected DBP and MBP, but significantly decreased SBP by 11.9% 4 h after the administration. Long-term treatment of conscious rats with （±）doxazosin significantly decreased SBP, DBP and MBP with a maximal decrease of SBP by 29.3% 8 h after the last administration. The rank order of the hypotensive actions caused by long-term treatment in conscious rats was （±）doxazosin〉（＋）doxazosin〉〉（–）doxazosin. However, the pKB values for inhibiting NA-induced contraction of isolated rat caudal artery were （＋）doxazosin （8.995）〉（±）doxazosin （8.694）〉（–）doxazosin （8.032）. The plasma concentrations of （–）doxazosin, （＋）doxazosin, and （±）doxazosin were 18.26±3.55, 177.11±20.66, and 113.18±13.21 ng/mL, respectively, 8 h after the last administration of these agents. Conclusion： Long-term treatment with （±）doxazosin produces potent hypotensive action in conscious rats that seems to result from synergic interaction of the two enantiomers.

Background： Neuromyelitis optica （NMO） and multiple sclerosis （MS） are demyelinating disorders of the central nervous system. Interferon regulatory factor 5 （IRF5） is a common susceptibility gene to different autoimmune disorders. However, the association of IRF5 variants with NMO and MS patients has not been well studied. Therefore, we aimed to evaluate whether IRF5 variants were associated with NMO and MS in the Southeastenl Han Chinese population. Methods： Four single nucleotide polymorphisnls （SNPs） were selected and genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometry in 111 NMO patients, 145 MS patients and 300 controls from Southeastern China. Results： None of these 4 SNPs was associated with NMO or MS patients. Conclusions： Our preliminary study indicates that genetic variants in IRI~ may affect neither NMO nor MS in the Southeastern Han Chinese population. Further studies with a large sample size and diverse ancestry populations are needed to clarify this isstie.

Background： Neuromyelitis optica （NMO） and multiple sclerosis （MS） are autoimmune demyelinating diseases of the central nerve system, lnterleukin-7 （IL-7） and interleukin-7 receptor alpha （IL-7Rα） were proved to be important in the pathogenesis of both diseases because of the roles they played in the differentiations of autoimmune lymphocytes. The variants of both genes had been identified to be associated with MS susceptibility in Caucasian, Japanese and Korean populations. However, the association of these variants with NMO and MS has not been well studied in Chinese Southeastern Han population. Here, we aimed to evaluate the association of six IL-7 variants （rsl520333, rs1545298, rs4739140, rs6993386, rs7816065, and rs2887502） and one variant of IL-7RA （rs6897932） with NMO and MS among Chinese Han population in southeastern China. Methods： Matrix-assisted laser desorption/ionization time of flight mass spectrometry （MassARRAY system） and Sanger sequencing were used to determine the variants of IL-7 and IL-7RA in 167 NMO patients, 159 MS patients and 479 healthy controls among Chinese Han population in southeastern China. Samples were excluded if the genotyping success rate 〈90%. Results： Statistical differences were observed in the genotypes of IL-7 rs1520333 in MS patients and IL-7RA rs6897932 in NMO patients, compared with healthy controls （P = 0.035 and 0.034, respectively）. There was a statistically significant difference in the genotypes of IL-7 rs2887502 between MS and NMO patients （P = 0.014）. And there were statistically significant differences in the rs6897932 genotypes （P = 0.004） and alleles （P = 0.042） between NMO-IgG positive patients and healthy controls. Conclusions： The study suggested that among Chinese Hart population in southeastern China, the variant of IL-7RA （rs6897932） was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 （rs1520333） with MS patients. And the genotypic differences of IL-7 rs2887502 between MS and NMO indicated the different genetic backgrounds of these two diseases.

Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclinl-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapperl （Dprl） acts as a critical regulator of the Beclinl-Vps34-Atg14L complex to promote autophagy. Dprl ablation in the central nervous system results in motor coordination defect and accumulation of p62 and ubiquitinated proteins. Dprl increases autophagosome formation as indicated by elevated puncta formation of LC3, Atg14L and DFCP1 （Double FYVE-containing protein 1）. Conversely, loss of Dprl impairs LC3 lipidation and causes p62/SQSTM1 accumulation. Dprl directly interacts with Beclinl and Atg14L and enhances the Beclinl-Vps34 interaction and Vps34 activity. Together, our findings suggest that Dprl enhances the Atg14L-Beclinl-Vps34 complex formation to drive autophagy.

Changes of total nitrogen (TN), organic matter, microbial metabolic activity, aerobic denitrifying bacteria and aerobic denitrifying genes (nirS and nirK) in water and surface sediments under mixing aeration were studied in Heihe Jinpen Reservoir. Results showed that compared with the control area, the total nitrogen concentration of water and surface sediments in the enhanced area decreased by 29.7%~49.2% and 17.9%. Metabolic activity of microorganisms increased by more than 14%, the utilization rate of carbon source increased by 30% and the McIntosh diversity index of microorganisms increased by 20%. The number of aerobic denitrifiers and genes of aerobic denitrifiers were also increased by 20%. Illumina high-throughput DNA sequencing results showed that the proportion of aerobic denitrifiers such as Acidovorax increased from 0.01% to 0.15%, showing an increase by 15 times. The production practice showed that mixed aeration can improve the metabolic activity and denitrification characteristics of indigenous aerobic denitrifiers, providing theoretical support and technical guarantee for denitrification and carbon removal of slightly polluted source water.

Dear Editor, Parkinson＇s disease （PD） is a neurodegenerative disease that afflicts around 1% of the population over age 65 [1]. One of the pathological hallmarks of PD is the degeneration of dopaminergic （DA） neurons at midbrain and the relatively focal lesion feature of PD makes cell replacement a promising approach for treating the dis- ease [2].