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Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
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Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
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Journal Article
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
2012
Overview
Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differenti- ated somatic cell into a multipotent state without first establishing pluripotency. Here, we demonstrate that sertoli cells derived from mesoderm can be directly converted into a multipotent state that possesses neural stem/progenitor cell properties. The induced neural stem/progenitor cells （iNSCs） express multiple NSC-specific markers, exhibit a global gene-expression profile similar to normal NSCs, and are capable of self-renewal and differentiating into glia and electrophysiologically functional neurons, iNSC-derived neurons stain positive for tyrosine hydroxylase （TH）, y-aminobutyric acid, and choline acetyltransferase. In addition, iNSCs can survive and generate synapses following transplantation into the dentate gyrus. Generation of iNSCs may have important implications for disease modeling and regenerative medicine.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Choline O-Acetyltransferase - metabolism
/ Electrophysiological Phenomena
/ Fluorescent Antibody Technique
/ gamma-Aminobutyric Acid - metabolism
/ Glia
/ Male
/ Mesoderm
/ Mice
/ Multipotent Stem Cells - cytology
/ Multipotent Stem Cells - metabolism
/ Neural Stem Cells - cytology
/ Neural Stem Cells - metabolism
/ Neural Stem Cells - transplantation
/ Neurons
/ Original
/ Stains
/ Synapses
/ Tyrosine 3-Monooxygenase - metabolism
/ Y-氨基丁酸
/ 定义
/ 神经干细胞
/ 神经胶质细胞
/ 胆碱乙酰转移酶
/ 酪氨酸羟化酶
/ 重编程
