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Background With the global aging population, attention to the health and medical issues of older adults is increasing. By analyzing the relationship between older people's participation in outdoor activities and medical expenditure, this study aims to provide a scientific basis for improving their quality of life and reducing the medical burden. Methods Data on outdoor activity participation, medical expenditures, and relevant variables were collected through questionnaires and databases. A multi-chain mediation effect model was established to analyze the impact of outdoor activities on the medical expenditure of older people, considering mediation effects and heterogeneity. Results Results revealed that increased participation in outdoor activities among older adults correlated with lower medical expenditures. Outdoor activities positively influenced their health by improving mental health, cognition, eating habits, and activities of daily living, resulting in reduced medical expenditures. Robustness tests confirmed the consistent effect of outdoor activities on older people's medical expenditure. Conclusion These findings contribute to understanding the relationship between outdoor activities, health, and medical expenditure in older people, guiding policy formulation and interventions. Encouraging and supporting older adults in outdoor activities can enhance their quality of life and alleviate medical resource strain. The study's conclusions can also inform health promotion measures for other populations and serve as a basis for future research in this area.

The second near-infrared (NIR II) response photon up-conversion (UC) materials show great application prospects in the fields of biology and optical communication. However, it is still an enormous challenge to obtain efficient NIR II response materials. Herein, we develop a series of Er 3+ doped ternary sulfides phosphors with highly efficient UC emissions under 1532 nm irradiation. β-NaYS 2 :Er 3+ achieves a visible UC efficiency as high as 2.6%, along with high brightness, spectral stability of lights illumination and temperature. Such efficient UC is dominated by excited state absorption, accompanied by the advantage of long lifetimes ( 4 I 9/2 , 9.24 ms; 4 I 13/2 , 30.27 ms) of excited state levels of Er 3+ , instead of the well-recognized energy transfer UC between sensitizer and activator. NaYS 2 :Er 3+ phosphors are further developed for high-performance underwater communication and narrowband NIR photodetectors. Our findings suggest a novel approach for developing NIR II response UC materials, and simulate new applications, eg., simultaneous NIR and visible optical communication. Development of efficient upconversion (UC) phosphors that emit under irradiation in the NIR II region is challenging - most UC materials rely on the presence of sensitizers absorbing at shorter wavelengths. Here, authors synthesize Er 3+ doped ternary sulfides phosphors with visible UC efficiency up to 2.6% and long emission lifetimes under 1532 nm irradiation, via an excited state absorption mechanism.

AP2/ERF transcription factor family plays an important role in plant development and stress responses. Previous studies have shed light on the evolutionary trajectory of the AP2 and DREB subfamilies. However, knowledge about the evolutionary history of the ERF subfamily in angiosperms still remains limited. In this study, we performed a comprehensive analysis of the ERF subfamily from 107 representative angiosperm species by combining phylogenomic and synteny network approaches. We observed that the expansion of the ERF subfamily was driven not only by whole-genome duplication (WGD) but also by tandem duplication (TD) and transposition duplication events. We also found multiple transposition events in Poaceae, Brassicaceae, Poales, Brassicales, and Commelinids. These events may have had notable impacts on copy number variation and subsequent functional divergence of the ERF subfamily. Moreover, we observed a number of ancient tandem duplications occurred in the ERF subfamily across angiosperms, e.g., in Subgroup IX, IXb originated from ancient tandem duplication events within IXa. These findings together provide novel insights into the evolution of this important transcription factor family.

Chimeric antigen receptor T (CAR-T) cell therapy has exhibited a substantial clinical response in hematological malignancies, including B-cell leukemia, lymphoma, and multiple myeloma. Therefore, the feasibility of using CAR-T cells to treat solid tumors is actively evaluated. Currently, multiple basic research projects and clinical trials are being conducted to treat lung cancer with CAR-T cell therapy. Although numerous advances in CAR-T cell therapy have been made in hematological tumors, the technology still entails considerable challenges in treating lung cancer, such as on−target, of−tumor toxicity, paucity of tumor-specific antigen targets, T cell exhaustion in the tumor microenvironment, and low infiltration level of immune cells into solid tumor niches, which are even more complicated than their application in hematological tumors. Thus, progress in the scientific understanding of tumor immunology and improvements in the manufacture of cell products are advancing the clinical translation of these important cellular immunotherapies. This review focused on the latest research progress of CAR-T cell therapy in lung cancer treatment and for the first time, demonstrated the underlying challenges and future engineering strategies for the clinical application of CAR-T cell therapy against lung cancer.

Background Triacylglycerols (TAGs) are the main composition of plant seed oil. Long-chain acyl-coenzyme A synthetases (LACSs) catalyze the synthesis of long-chain acyl-coenzyme A, which is one of the primary substrates for TAG synthesis. In Arabidopsis , the LACS gene family contains nine members, among which LACS1 and LACS9 have overlapping functions in TAG biosynthesis. However, functional characterization of LACS proteins in rapeseed have been rarely reported. Results An orthologue of the Arabidopsis LACS2 gene ( BnLACS2 ) that is highly expressed in developing seeds was identified in rapeseed ( Brassica napus ). The Bn LACS2-GFP fusion protein was mainly localized to the endoplasmic reticulum, where TAG biosynthesis occurs. Interestingly, overexpression of the BnLACS2 gene resulted in significantly higher oil contents in transgenic rapeseed plants compared to wild type, while BnLACS2 -RNAi transgenic rapeseed plants had decreased oil contents. Furthermore, quantitative real-time PCR expression data revealed that the expression of several genes involved in glycolysis, as well as fatty acid (FA) and lipid biosynthesis, was also affected in transgenic plants. Conclusions A long chain acyl-CoA synthetase, Bn LACS2 , located in the endoplasmic reticulum was identified in B. napus . Overexpression of BnLACS2 in yeast and rapeseed could increase oil content, while BnLACS2 -RNAi transgenic rapeseed plants exhibited decreased oil content. Furthermore, BnLACS2 transcription increased the expression of genes involved in glycolysis, and FA and lipid synthesis in developing seeds. These results suggested that BnLACS2 is an important factor for seed oil production in B. napus .

The Fermi rule states that rational or irrational sentiment affects individual decision-making. Existing studies have assumed that individuals’ irrational sentiments and behavior willingness have fixed values and do not change with time. In reality, people’s rationality sentiment and behavior willingness may be influenced by some factors. Therefore, we propose a spatial public goods game mechanism, in which individuals’ rational sentiment is co-evolution synchronously depending on the difference between aspiration and payoff. Moreover, the intensity of their subjective willingness to change the status quo depends on the gap between aspiration and payoff. We likewise compare the combined promotion effect of the stochastic “Win-Stay-Lose-Shift” ( WSLS ) and random imitation ( IM ) rules. Simulation experiments indicate that high enhancement factors are not conducive to cooperation under the IM rules. When aspiration is small, WSLS is more conducive to promoting cooperation than IM , while increasing aspiration, and the opposite phenomenon will appear. The heterogeneous strategic update rule is beneficial to the evolution of cooperation. Lastly, we find that this mechanism performs better than the traditional case in enhancing cooperation.

Biologists have long debated the drivers of the genome size evolution and variation ever since Darwin. Assumptions for the adaptive or maladaptive consequences of the associations between genome sizes and environmental factors have been proposed, but the significance of these hypotheses remains controversial. is a large genus in the grass family and is often used as crop or forage during the dry seasons. The wide range and complex ploidy levels make an excellent model for investigating how the genome size variation and evolution is associated with environmental factors and how these changes can ben interpreted. We reconstructed the phylogeny and estimated genome sizes through flow cytometric analyses. Phylogenetic comparative analyses were performed to explore how genome size variation and evolution is related to their climatic niches and geographical ranges. The genome size evolution and environmental factors were examined using different models to study the phylogenetic signal, mode and tempo throughout evolutionary history. Our results support the monophyly of . The genome sizes in ranged from ~0.66 pg to ~3.80 pg. We found that a moderate phylogenetic conservatism existed in terms of the genome sizes but was absent from environmental factors. In addition, phylogeny-based associations revealed close correlations between genome sizes and precipitation-related variables, indicating that the genome size variation mainly caused by polyploidization may have evolved as an adaptation to various environments in the genus . This is the first study to take a global perspective on the genome size variation and evolution in the genus . Our results suggest that the adaptation and conservatism are manifested in the genome size variation, allowing the arid species of to spread the xeric area throughout the world.

The pressure drop characteristics of subcooled water were experimentally investigated in a circular cooling channel with and without a twisted tape (TT) under high heat fluxes, which was designed for the water-cooling structure of the divertor target in a tokamak device. The working medium was deionized water, and the main parameters were mass flux G = 3000–8000 kg·m−2·s−1, inlet pressure of the test section p = 3, 4.2, 5 MPa, equivalent one-side heating flux qe = 5~10 MW·m−2. The off-center circular channel is electrically heated to simulate the unilateral radiation heating on the divertor target by high-temperature plasma. The pressure drop experiment of vertical upward circular cooling channels under high and unilateral heat flux is carried out. The influences of the TT and system parameters such as qe, G, and p on the pressure drop of the test section (Δp) were discussed in detail. In the single-phase (SP) flow region, Δp is mainly affected by the TT, G, and qe. The pressure drop with a TT is significantly higher than that without a TT, a higher G and a lower qe lead to a greater Δp. In the subcooled boiling (SB) flow region, Δp is correlated with the TT, qe, G, and p: the influence of the TT and G decreases, while the influence of p increases. The higher the qe, the higher the G, and the lower the p, the larger the Δp. The results show that almost all of the SP pressure drop correlations for heated circular channels overestimate the experimental pressure drop coefficient ratio for a given viscosity ratio. According to the test results, a new correlation of SP pressure drop under high and unilateral heat fluxes has been proposed, the average error (AE) and root mean square error (RMSE) of which are 0.26% and 3.17%, respectively.

To study the pressure drop characteristics of hypervapotron, which was designed as a water-cooling structure in the divertor dome of the fusion reactor, the pressure drop tests of subcooled water were carried out in a vertically upward hypervapotron. To simulate the one-side radiant heating condition in the engineering application, the non-uniform heat fluxes were obtained by using the off-center electrically heating method. The system parameters were as follows: mass flux G = 2000–5000 kg·m−2·s−1, inlet pressure p = 2–4 MPa, and equivalent one-side radiating heat flux qe = 0–5 MW·m−2. The effects of the parameters on the pressure drop were discussed in detail. It was observed that in the single-phase (SP) region, the pressure drop was little influenced by the inlet fluid temperature (Tb,in). However, in the subcooled boiling region, the pressure drop increased rapidly with the increasing Tb,in. A higher G leads to a high pressure drop. In the SP region, the influence of p on the pressure drop is not obvious, and the pressure drop decreased with the increasing qe. The test data are used to evaluate the typical pressure drop correlation, and the results show that none of these correlations can predict the pressure drop well under the test conditions. Therefore, a new pressure drop correlation is proposed for subcooled water in a hypervapotron under high and non-uniform heat fluxes. The new correlation has a high prediction accuracy for the test data, and the mean relative error (MRE) and root mean square error (RMSE) are 0.72% and 4.33%, respectively. The test results have a reference value for the design of the water-cooling structure of the diverter.

Low-cost, high-performance, and uncooled broadband photodetectors (PDs) have potential applications in optical communication etc., but it still remains a huge challenge to realize deep UV (DUV) to the second near-infrared (NIR-II) detection for a single broadband PD. Herein, a single PD affording broadband spectral response from 200 to 1700 nm is achieved with a vertical configuration based on quantum dots (QDs) heterojunction and quantum cutting luminescent concentrators (QC–LC). A broadband quantum dots heterojunction as absorption layer was designed by integrating CsPbI3:Ho3+ perovskite quantum dots (PQDs) and PbS QDs to realize the spectral response from 400 to 1700 nm. The QC–LC by employing CsPbCl3:Cr3+, Ce3+, Yb3+, Er3+ PQDs as luminescent conversion layer to collect and concentrate photon energy for boosting the DUV–UV (200–400 nm) photons response of PDs by waveguide effect. Such broadband PD displays good stability, and outstanding sensitivity with the detectivity of 3.19 × 1012 Jones at 260 nm, 1.05 × 1013 Jones at 460 nm and 2.23 × 1012 Jones at 1550 nm, respectively. The findings provide a new strategy to construct broadband detector, offering more opportunities in future optoelectronic devices.Highly DUV to NIR-II responsive broadband quantum dots heterojunction photodetectors.