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This study aimed to review and examine the tools used to assess psychomotor performance of children with visual impairment. Databases, such as SCOPUS, MEDLINE/PubMed, Medline/EBSCO, Web of Science, LILACS, CINAHL, and ScienceDirect, were searched using Mesh terms. Data from manuscripts fully available in these databases between 1994 and 2017 (except CINAHL—2014) concerning the evaluation, tool development, or intervention for the improvement of motor skills in children (age, 7-10 years) with visual impairment were collected. The Critical Review Form—Quantitative Studies was used to evaluate the quality of the articles. As a result, 1113 articles were found, but only 24 met the inclusion criteria; 66.7% of the articles had moderate quality, with unsatisfactory results regarding the validity and reliability of the tools used to assess these children, as well as the absence of clinical importance and practical application in such studies. Only the Test of Gross Motor Development-2 and Movement Assessment Battery for Children-2 described data on the validation and reliability in visually impaired children. To minimize systematic errors and improve the quality of the investigations, increasing the number of studies regarding the tools, functionality of their activities, and testing the adaptions is necessary.

This study aimed to review the scientific evidence on associations between motor competence (MC) and components of health related physical fitness (HRPF), in children and adolescents. Systematic review. Systematic search of Academic Search Premier, ERIC, PubMed, PsycInfo, Scopus, SportDiscus, and Web of Science databases was undertaken between October 2012 and December 2013. Studies examining associations between MC and HRPF components (body weight status, cardiorespiratory fitness, musculoskeletal fitness and flexibility) in healthy children and adolescents, published between 1990 and 2013, were included. Risk of bias within studies was assessed using CONSORT and STROBE guidelines. The origin, design, sample, measure of MC, measure of the HRPF, main results and statistics of the studies were analyzed and a narrative synthesis was conducted. Forty-four studies matched all criteria; 16 were classified as low risk of bias and 28 as medium risk. There is strong scientific evidence supporting an inverse association between MC and body weight status (27 out of 33 studies) and a positive association between MC and cardiorespiratory fitness (12 out of 12 studies) and musculoskeletal fitness (7 out of 11 studies). The relationship between MC and flexibility was uncertain. Considering the noted associations between various assessments of MC and with multiple aspects of HRPF, the development of MC in childhood may both directly and indirectly augment HRPF and may serve to enhance the development of long-term health outcomes in children and adolescents.

The aim of this study was to investigate the performance of children and adolescents with low vision on the Pediatric Balance Scale (PBS), in different age groups. The PBS was administered to 41 subjects, aged 5 to 14 years, with low vision and no other associated disorders. The Spearman correlation coefficient was used for correlation between age and the score achieved on the scale. There was a correlation of 0.52 between the score obtained on the PBS and the age. The variation of score was greater in children between 5 to 7 years and minimal in older age groups. The maximum score was obtained by all the subjects on six items of the scale. The PBS score had significant correlation with age up to a point, reaching ceiling effect on various items. It showed to be an easy application screening tool in children and adolescents with low vision, being more suitable for children 5-7 years old.

Ganoderma lucidum (a mushroom used in traditional Chinese medicine) compounds may attenuate ageing-related physiological changes and restore normal immunity. However, studies on the physiological effects of Ganoderma lucidum dry extract food supplements are few. Therefore, here, we aimed to investigate the effects of Ganoderma lucidum dry extract food supplement on the lymphocyte function of older women. This was a double-blind clinical trial (n 60) with a final 39 older volunteers, divided into two groups Ganoderma lucidum (n 23) and placebo (n 16). The Ganoderma lucidum group received 2000 mg/d of Ganoderma lucidum dry extract for 8 weeks. We used flow cytometry to determine the lymphocyte profile. CD4+ lymphocyte gene expression was evaluated by real-time polymerase chain reaction. We observed that in the Ganoderma lucidum group, concanavalin A stimulation increased lymphocyte proliferation. Further, we observed an increase in expression of Forkhead box P3, transforming growth factor-beta, IL-10, IL-6, retinoic acid receptor-related orphan receptor gamma, GATA-binding protein 3 and interferon gamma genes in the Ganoderma lucidum group. Furthermore, in the Ganoderma lucidum group, ionomycin and phorbol 12-myristate 13-acetate stimulation led to decrease in Th17+ cells and increase in Th2+ cells. Thus, in older women, Ganoderma lucidum regulates T lymphocyte function leading to a predominant anti-inflammatory action but does not induce T lymphocyte proliferation through CD28 signalling pathway.

Given this context, considering that instruments currently used for risk classification are developed and validated specifically for each country's scenario and focused on hospital care, it is necessary to develop and validate a risk classification instrument for use in PHC emergency services within the Unified Health System (SUS)0315). Categorical variables were described by absolute frequency and percentages, while numerical variables were described by mean and standard deviation or medians and quartiles, depending on the data distribution.The relationships between each variable obtained in RC and outcomes were analyzed using hypothesis tests and correlation coefficients, depending on the data nature. Content Validation Inclusion criteria were: i) being a doctor or nurse with at least five years of experience, and ii) working in Brazilian public urgency and emergency services; intensive care units; PHC; or university teaching with research experience in urgency and emergency care. Data Collection After verifying eligibility criteria, theTCLE was sent via email along with a link to the CR instrument evaluation form, accompanied by detailed information and/or images on the proposed items for validation (supplementary material).

Background/Objectives: Goto-Kakizaki (GK) rats exhibit insulin resistance and type 2 diabetes mellitus (T2DM) without obesity. This study explored the effects of ω-3 fatty acid supplementation on T lymphocyte polarization in Wistar (WT) and GK rats. Methods: They were administered ω-3 fatty acid-rich fish oil (FO) containing eicosapentaenoic (540 mg/g) and docosahexaenoic acids (100 mg/g) by oral gavage at 2 g/kg, thrice a week for 8 weeks. The control groups (WT CT and GK CT) received the same volume of water. The following groups were investigated: GK CT, n = 14; GK ω-3, n = 15; Wistar CT, n = 15; and Wistar ω-3, n = 11. Glucose and insulin tolerance tests (GTT and ITT) were performed. Fasting plasma insulinemia and glycemia were measured. After euthanasia, the lymphocytes were extracted from the mesenteric lymph nodes. Results: The results showed that GK rats supplemented with FO had significantly improved glucose tolerance and insulin sensitivity (kITT). It also promoted greater polarization of lymphocytes toward T regulatory (Treg) features and a reduction in Th1 and Th17 profiles. Additionally, the GK ω-3 group exhibited lower cell proliferation, decreased pro-inflammatory cytokines, and increased IL-10 levels compared to the GK control. Conclusions: In conclusion, FO supplementation benefited GK rats by improving glucose intolerance, suppressing insulin resistance, and modulating lymphocytes toward Treg polarization.

Rates of mental health issues have been increasing among university students. This study investigates the effects of the Interculturality and Mindfulness Program (PIM) on academic students on mindfulness, emotional regulation, depression, anxiety, stress, life satisfaction, optimism, positive solitude, and loneliness. A quasi-experimental research was conducted, with pre- and post-test comparative measurements in three groups: in-person (IG), synchronous online (OG), and passive control (CG). A diverse group of students (n = 150; mean age = 25.4 ± 8.31) participated from two universities in Portugal. When compared to the CG, both active groups (IG and OG) demonstrated a beneficial interaction effect in acceptance, positive solitude, optimism, and mindfulness. The IG demonstrated a positive interaction effect in awareness and satisfaction with life, whereas the OG indicated a favorable interaction effect in impulse. When analyzing the intra-group effects, both active groups presented a significant improvement in stress, emotion regulation, mindfulness, positive solitude, and optimism. The OG demonstrated an improvement in awareness and loneliness. The main limitations of this research are that students were not randomly assigned, and groups were heterogeneous in nationality, education level, and sex. Nonetheless, PIM has indicated beneficial results in both IG and OG, and is a promising intervention for the prevention of mental health issues (e.g., stress, difficulties in emotional regulation, and loneliness), as well as for the promotion of well-being (e.g., positive solitude, mindfulness, life satisfaction, and optimism).

Global temperatures have led to an increasing need for air conditioning systems. So, because of this fact, buildings have been improved in terms of their thermal and energy efficiency. Regarding this, the Brazilian standard ABNT NBR 15.575-4/2013 set minimum parameters for the thermal transmittance and thermal capacity of sealing elements, which allow classifying the thermal efficiency of the building. In order to comply with the requirements, the usage and study of lightweight construction materials have been in focus. An example of these materials is vermiculite. The present research reviewed articles about expanded vermiculite. The study involved the examination and comparison of various articles to analyze the properties of vermiculite and the impact of its usage on coating mortars. It was possible to verify that using vermiculite in mortars caused bad workability and a decrease in mechanical strength. However, the porosity and water absorption in mortars increased. Additionally, it reduced the specific weight and the thermal conductivity of the mortars, allowing for a better thermal insulation of the rooms. As an alternative to decreasing the negative effects of vermiculite, it is possible to use chemical admixtures, mineral additions, and mix design with a greater consumption of binder or a combination of particle sizes.

Streptococcus agalactiae, known as group B streptococci (GBS), colonizes the digestive and genitourinary tracts and causes neonatal diseases and infections in immunocompromised and elderly individuals. GBS neonatal disease prevention includes intrapartum antibiotic prophylaxis. We characterized 101 GBS isolates obtained from patients in João Pessoa, northeastern Brazil, owing to the need to develop and implement vaccines to prevent GBS infections. Capsular types were determined using multiplex-PCR, and antibiotic susceptibility profiles were determined using disc diffusion or the gradient strip method. Clonal diversity was evaluated using pulsed-field gel electrophoresis. Fourteen selected isolates had the genome sequenced and evaluated for virulence and resistance genes. The GBS population had high clonal diversity, with serotype Ia and V prevalence. Among the sequenced isolates, we detected antibiotic resistance genes (ant(6)-Ia, catA8, ermA, ermB, lsaE, lsnuB, mefA/msrD, tetM, tetO, and tetS), several virulence genes, and mobile genetic elements integrated into the chromosome. The most frequent Sequence Type (ST) was ST144, followed by ST196, ST28, ST19, ST12, ST23, ST103, and the new ST1983 (CC103). Phylogenetically, ST103 and ST1983 were distant from the other STs. Our data revealed highly virulent GBS strains in this population and a new ST that could be related to a zoonotic origin.

Abstract Rough mutants of Brucella abortus were generated by disruption of wbkC gene which encodes the formyltransferase enzyme involved in LPS biosynthesis. In bone marrow-derived macrophages the B. abortus ΔwbkC mutants were attenuated, could not reach a replicative niche and induced higher levels of IL-12 and TNF-α when compared to parental smooth strains. Additionally, mutants exhibited attenuation in vivo in C57BL/6 and interferon regulatory factor-1 knockout mice. Δ wbkC mutant strains induced lower protective immunity in C56BL/6 than smooth vaccine S19 but similar to rough vaccine RB51. Finally, we demonstrated that Brucella wbkC is critical for LPS biosynthesis and full bacterial virulence.