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Genomic Diversity, Virulome, and Resistome of Streptococcus agalactiae in Northeastern Brazil: Are Multi-Host Adapted Strains Rising?
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Genomic Diversity, Virulome, and Resistome of Streptococcus agalactiae in Northeastern Brazil: Are Multi-Host Adapted Strains Rising?
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Journal Article
Genomic Diversity, Virulome, and Resistome of Streptococcus agalactiae in Northeastern Brazil: Are Multi-Host Adapted Strains Rising?
2025
Overview
Streptococcus agalactiae, known as group B streptococci (GBS), colonizes the digestive and genitourinary tracts and causes neonatal diseases and infections in immunocompromised and elderly individuals. GBS neonatal disease prevention includes intrapartum antibiotic prophylaxis. We characterized 101 GBS isolates obtained from patients in João Pessoa, northeastern Brazil, owing to the need to develop and implement vaccines to prevent GBS infections. Capsular types were determined using multiplex-PCR, and antibiotic susceptibility profiles were determined using disc diffusion or the gradient strip method. Clonal diversity was evaluated using pulsed-field gel electrophoresis. Fourteen selected isolates had the genome sequenced and evaluated for virulence and resistance genes. The GBS population had high clonal diversity, with serotype Ia and V prevalence. Among the sequenced isolates, we detected antibiotic resistance genes (ant(6)-Ia, catA8, ermA, ermB, lsaE, lsnuB, mefA/msrD, tetM, tetO, and tetS), several virulence genes, and mobile genetic elements integrated into the chromosome. The most frequent Sequence Type (ST) was ST144, followed by ST196, ST28, ST19, ST12, ST23, ST103, and the new ST1983 (CC103). Phylogenetically, ST103 and ST1983 were distant from the other STs. Our data revealed highly virulent GBS strains in this population and a new ST that could be related to a zoonotic origin.
Publisher
MDPI AG,MDPI
Subject
Anti-Bacterial Agents - pharmacology
/ Antigens
/ Bacteria
/ Diseases
/ Drug resistance in microorganisms
/ Electrophoresis, Gel, Pulsed-Field
/ Enzymes
/ Female
/ GBS
/ Genes
/ Genomes
/ Genomics
/ Humans
/ Male
/ Neonates
/ Proteins
/ Pulsed-field gel electrophoresis
/ Streptococcal Infections - epidemiology
/ Streptococcal Infections - microbiology
/ Streptococcus agalactiae - classification
/ Streptococcus agalactiae - drug effects
/ Streptococcus agalactiae - genetics
/ Streptococcus agalactiae - isolation & purification
/ Streptococcus agalactiae - pathogenicity
/ Vaccines
