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Background: Oxidative stress resulting from increased free radicals and decreased antioxidants can be controlled by consuming natural antioxidants from safe sources such as red radish and soybean seeds and sprouts. Methods The chemical composition, antinutritional factors, total polyphenols, total flavonoids and antioxidant activity by DPPH were estimated. Two main groups contain 36 rats split into the first group (ve-) 6 rats, and the second group 30 rats which took 2 g/kg BW from Paracetamol for 7 days. Then divided into 5 groups, (ve+), (ve-), 10% red radish seeds and 10% red radish sprouts, 20% soybean seeds and 20% soybean sprouts for 6 weeks. MDA, GHS and CAT were evaluated. Results: significant differences in nutritional composition, polyphenols, flavonoids and antioxidant activity (DPPH). Sprouting was found to have significant nutritional value in both red radish and soybean sprouts. A Supplementation diet with 20% sprouted of soybean and 10% red radish sprouts demonstrated strong antioxidant activity across all macroscopic and biochemical parameters tested.

Oxidative stress plays an important role in the development of diabetic complications. Urtica dioica L. has been traditionally used as an herbal remedy for hypoglycemic. The aim of the present study was to evaluate the effect of stinging Nettle Leaves powder (NLP) and its aqueous extract (NLAE) on oxidative stress status of rats with diabetic nephropathy, The results at the end of biological experiment for diabetic rats fed on basal diet supplemented with NLP or NLAE may be helping to maintain an ideal body weight and feed efficiency ratio This study recommended that Urtica dioica L. is suitable for diabetic patients with nephropathy.

Oxidative stress plays an important role in the etiology and pathogenesis of many chronic diseases. Dietary intake of antioxidants can inhibit or delay the oxidation of susceptible cellular substrates so prevent oxidative stress. The present study was designed to investigate potential protective and ameliorate effects of pineapple and kumquat powders against potassium bromate (KBrO3)-induced oxidative stress using experimental rats. Whole kumquat (seedless), kumquat seeds, pineapple flesh and pineapple leaves were analyzed for phenolic compounds. Measurement of potential of cytotoxicity against the liver carcinoma cell line (HEPG2) carried out by SRB assay of the ethanolic extract of whole kumquat seedless, kumquat seeds, whole kumquat, pineapple flesh, pineapple leaves, pineapple (flesh +leaves) and mixture of them.

يلعب الإجهاد التأكسدي دورا فعالا في تطوير الأمراض المختلفة بما في ذلك مرض السكري، وينتج عنه عدم التوازن في إنتاج مضادات الأكسدة. وتهدف هذه الدراسة إلى دراسة حالة نظام التأكسد في الفئران المصابة بمرض السكريوالتي تتغذي على بعض أجزاء النبات المختارة مثل (MLWE)، (OFWE) (CLWE)، وخليطهم. تسببت معاملة الفئران بالألوكسينوسيد في زيادة معنوية (P ≤ 0.05) في تركيز الجلوكوز بالدم بنسبة (136.51%) مقارنة بالمجموعة السالبة (-) وعند إضافة ٢% من وزن (OFWE MLWE)، (CLWE)، وخليطهم للمكملات الغذائية للفئران انخفضت هذه القيمة مقارنة بالمجموعة الضابطة وسجلت 57.35%، 38.69%، 52.27%، 35.48% على التوالي كما أن استهلاك (CLWE)، (ML WE)، (OFWE)، وخليطهم تسبب في تحسينات كبيرة في تركيز الجلوتاثيون في السيرم من خلال زيادة (GSSG GSH مقارنة مع الضوابط العادية بنسبة- 15.31- 11.22، -14.28& -7.14% & -15.31، 11.22، - 7.14، -14.29 على التوالي، وقد لوحظ الاتجاه المعاكس مع المواد المؤكسدة البيولوجية (NO2) NO3) كما تدعم الدراسة الحالية فوائد التعديل الغذائي لتخفيف الإجهاد التأكسدي المرتبط بالسكري

Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueousethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N. sativa (100, 200 mg/kg). Duration of this study was 11 days and cisplatin was injected on the 6th day of the experiment. Tissue damage in all groups that received N. sativa extract and Vitamin E showed a significant improvement compared with the cisplatin group. In addition, serum and tissue total thiol content in preventive and preventive + treatment N. sativa groups showed significant increase compared with cisplatin group. There was no significant difference in serum malondialdehyde concentration of the control rats compared with the preventive and preventive + treatment N. sativa groups. N. sativa extract and viamin E improved the pathology and oxidative stress in the rat kidney. However, more studies are needed to determine the mechanism of action of N. sativa on cisplatin-induced kidney toxicity

Background: Depression is a severe mental disorder. Current antidepressants are effective in only one-half to one-third of the patients. Besides, these medications might bring about adverse effects. Therefore, the need for newer anti-depressant medications or complementary compounds is utterly felt. Objectives: We tested the hypothesis that geraniol (GE) attenuates anxiety and depression via the amelioration of oxidative stress and apoptosis in mice. Methods: In an experimental study, thirty-six BALB/c mice were randomly divided into three control, chronic restraint stress (CRS), and GE groups. CRS and GE groups underwent CRS for two weeks. Accordingly, the CRS group received normal saline (2 mL/kg, i.p.) whereas the GE group received GE (50 mg/kg, i.p.). The behavioral outcomes were assessed using the open-field test (OFT), elevated plus maze (EPM), and tail suspension test (TST). Moreover, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-px) activity, total antioxidant capacity (TAC), and reactive oxidative species (ROS) levels in the brain were assessed using the spectrophotometric method. The brain’s BAX, Bcl-2, and caspase-3 levels were measured usingWestern blotting. Results: CRS increased anxiety in stressed mice compared to the control group as indicated by OFT and EPM (P < 0.01 for both comparisons). Furthermore, CRS increased the immobility time in TST compared to control animals (P < 0.001). Biochemically, CRS decreased SOD activity (P < 0.01), GSH-px activity (P < 0.01), TAC level (P < 0.001), and ROS level (P < 0.001). It also increased the BAX/Bcl-2 ratio (P < 0.001) and caspase-3 level (P < 0.001) compared to the control group. GE reversed all the behavioral and biochemical changes in stressed mice compared to the CRS group. Conclusions: GE renders potent anxiolytic and antidepressant effects possibly through the modulation of oxidative stress and apoptosis in the mouse brain.