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هدف البحث إلى الكشف عن تأثير التدريبات الهوائية على بعض متغيرات اللياقة الصحية وكثافة العظام لدى السيدات البدينات المصابة بعرق النسا. استخدم البحث المنهج التجريبي ذو المجموعة الواحدة للقياسين القبلي والبعدي. وتمثلت أدوات البحث في إعداد قياسات المتغيرات البدنية، وتصميم برنامج التدريبات الهوائية، وبعض الأجهزة، ومنها (جهاز الرستاميتر، ميزان طبي، جهاز الديناموميتر، مقياس التناظر البصري، ساعة إيقاف، حزام من الجلد أو القماش، شريط قياس أطوال مدرج بالسنتيمتر، جهاز الجينوميتر، جهاز الإسبيروميتر، جهاز قياس كتلة الجسم، جهاز قياس كثافة محتوى معادن العظام، كرات طبية، كرات سويسرية، صناديق، مراتب). وطبقت أدوات على (40) سيدة من سيدات البدينات المصابات بعرق النسا من (40 إلى 50) سنة، المترددين على (صالة اللياقة البدنية) بمدينة سرس الليان وقرية سدود. وأسفرت نتائج البحث عن وجود فروق دالة إحصائياً بين القياس القبلي والبعدي في كثافة العظام للسيدات البدينات المصابة بعرق النسا في المرحلة السنية من (40-50) سنة لصالح القياس البعدي. لذلك أشارت النتائج أن التدريبات الهوائية المستخدمة لها تأثير إيجابي على تخفيف درجة الألم للسيدات البدينات المصابة بعرق النسا. وأوصى البحث بضرورة الاسترشاد بالتدريبات الهوائية المستخدمة وتعميم استخدامها في المراكز والمؤسسات العلاجية. كُتب هذا المستخلص من قبل دار المنظومة 2025

Background : Thalassemia syndromes are heterogeneous groups of inherited anemias. Its treatment depends on recurrent blood transfusion with a problem of iron overload, which leads to multiple endocrinopathies including hypoparathyroid. The aim of the study is to estimate the level of serum parathyroid hormone and its relation to bone mineral density in transfusion dependent beta-thalassemia major children. Subjects and methods : We measured serum calcium, phosphorus and parathyroid hormone in a sample of pediatric patients with thalassemia, compared them with age and sex matched healthy control. Measurement of bone mineral density by dual-energy X-ray absorptiometry was done in 2 sites : lumbar spine (L2–L4) in the anteroposterior position and left femur neck using Lunar Densitometry in osteoporosis Unit Ain Shams University Hospital for thalassemia patients. Results : Thalassemic patients had significantly higher alkaline phosphatase and lower bone mineral density. Conclusion : Osteopenia in b-thalassemia major patients is multifactorial and is mainly predisposed by defective function of the parathyroid gland and excessive iron deposition

Objectives : bone failure due to avascular necrosis (AVN) is a complex pathological phenomenon. analysis of molecular changes in the bone matrix may help to shed light on the disease process and guide management. this study aimed to explore changes in bone quality and structural damage caused by sickle cell disease (SCD)- induced AVN using Raman spectroscopy. methods : a total of 10 necrotic femoral heads were obtained from seven SCD patients who underwent total hip replacements. the femoral heads were cut in half and scanned using Raman spectroscopy in correlation with preoperative magnetic resonance imaging to identify necrotic and healthy control areas. Subsequently, samples were examined to determine changes in bone mineralisation, crystallinity, carbonate content, collagen cross-linking and mineral and collagen fibril orientation. results : Significant changes were observed in bone mineral content, mineral-to-organic content and collagen fibril orientation in necrotic compared to control areas (P ≤0.050). conclusion : the necrotic samples displayed severe structural damage and loss of mineral and organic contents. Similar Raman signals have been reported in other metabolic bone diseases such as osteoporosis, thereby potentially supporting the use of medical treatment in AVN to promote bone quality.

Children with idiopathic nephrotic syndrome are primarily treated with glucocorticoids (GCs), but long-term GC use can lead to undesired side effects. We investigated the bone mineral density (BMD) and 25-hydroxyvitamin D (25-OH D) levels in children with the remission phase of steroid-sensitive nephrotic syndrome (SSNS). This study included 32 patients with SSNS who had not received GC treatment in the last 6 months and a control group of 20 healthy children. Serum levels of calcium, phosphate, alkaline phosphatase, 25-(OH)D, and parathyroid hormone (PTH) were measured. BMD was determined in the lumbar spinal region using dual-energy X-ray absorptiometry (DEXA). Serum 25-(OH)D levels were lower in the SSNS patients than in the healthy children (P <0.05), with 22 patients (68.8%) having Z-scores <−1. The Z-scores were positively correlated with 25-(OH)D levels (r = 0.424, P <0.05). PTH levels were higher in patients with osteoporosis than in patients with Z-scores ≥−1 (P <0.05). Bone mineral content and BMD were positively correlated with the age of diagnosis (P <0.01). Receiver-operating characteristic curve analysis showed that the cutoff value of 25-(OH)D levels for predicting low BMD was 14.67 ng/mL with a sensitivity of 90% and a specificity of 64%. The area under the curve (AUC ± standard error) was 0.868 ± 0.064 (95% confidence interval: 0.742– 0.994, P = 0.001). Decreased 25-(OH)D levels and the negative effects of long-term GC treatment on BMD persist in SSNS remission phase. Levels of 25-(OH)D <14.67 ng/mL could predict abnormal DEXA scans in children with SSNS remission phase