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The increased incidence of cardiovascular diseases and hyperlipidemia was observed among the Egyptians in the last decades. The present study aims to explore the role of Purslane on some biological activities of hyperlipidemic rats. Therefore, different concentrations ranged 200 to 400 mg/kg body weight (BW) of Purslane extract were consumed by hyperlipidemic rats and the plasma total cholesterol, triglycerides, HDL-c, LDL-c, lipid peroxide as well as total antioxidants capacity levels were investigated. Results revealed that significant differences (P<0.01) among all experimental groups regarding total cholesterol, triglycerides, HDL-c, LDL-c, lipid peroxide and total antioxidants capacity levels were observed. Concentration of 400 mg/kg BW of purslane extract recorded the most decrease in all previous plasma parameters except the HDL-c and total antioxidant capacity levels which recorded the opposite direction.

This study was conducted to find out the potential effect of Sonchus oleraceus on biological, biochemical, and histological changes of hypercholesterolemic rats induced by high fat diets. Therefore, Thirty-two Adult male albino rats Sprague Dawley strains, weighing 102±1.85 gm were used, and were divided into two groups; the first group (8 rats) fed on basal diet throughout the experimental periods (16 weeks) and served as a negative control group (G1). The second group was fed a high fat diet containing cholesterol, then this group (n=24 rats) was divided into three subgroups (8 rats per each) as follows: The first subgroup continued to be fed on hypercholesterolemic diet (G2), The second subgroup fed on hypercholesterolemic diet supplemented with Sonchus Oleraceus 5 % (G3). The third subgroup fed on hypercholesterolemic diet supplemented with 10% Sonchus oleraceus (G4). The results revealed that hypercholesterolemic diet rat groups showed a significant increase in body weight from positive control (G2). Also increase significantly levels of lipid profile, liver enzymes (AST, ALT and ALP) and cholesterol, except high-density lipoprotein cholesterol (HDL-c) compared to negative control grope (G1). When feeding rats with a high hypercholesterolemic diet containing Sonchus oleraceus occur significant (P ≤ 0.05) decrease in body weight, liver enzymes (AST, ALT and ALP), kidney function and level of lipid profile (TC, TG, T. Lipid and LDL) and increase in the level of HDL. These results were confirmed with histopathological examination of liver, kidney, heart and brain. Therefore, we recommend using Sonchus oleraceus in moderate amount in our daily diets to benefit from its health benefits.

The present study aimed to examine the possibility of using purslane seeds powder to make bread and its effect on some vital functions in the experimental rats. For this purpose, bread was prepared by adding purslane seeds powder rates of 5%, 10% and 15% replacement. The effect of additives on the chemical composition, sensory and rheological properties of the produced bread were studied. A total of 24 male albino rats were divided into three equal groups (8 rats): control group C, group PS1 (5% purslane seeds powder), PS2 (10% purslane seeds powder) and at the end of the experimental period (7 weeks) the levels of TC, TG, HDL-c, LDL-c, AST, ALT, ALP, urea and creatinine were examined. Histopathology of the heart, liver and kidney was also examined. Results showed that the addition of purslane seeds powder (5%, 10% and 15% replacement) resulted in an increase in protein, fat, ash and fiber, and low carbohydrate and energy. The results of the sensory tests showed that PSB3 bread was not accepted (15% purslane seeds powder), whereas PSB1 (5% purslane seeds powder) was obtained by the highest percentage of acceptability after the control. The results of the farinograph tests showed an increase in water absorption and dough stability, and a decrease in arrival time and dough development time, and the results of the extensograph tests showed decrease in resistance to extension, extensibility, and energy, while showed increase in proportional number and maximum height. For the results of biological assessment the results showed a decrease in the weight gain, urea and creatinine, significant increase (P <0.05) in HDL-c, and significant decrease (P <0.05) in TG, TG, LDL-c, AST, ALT and ALP compared with control. The results of histopathological examination were shown that there were no bad effects of the purslane seeds powder on the liver, kidney and heart. The study recommends adding purslane seeds powder to bread and other foods, and further studies are needed to determine the optimal proportions of consumption.

This study looked at how Ginkgo biloba leaves (GB) and Cassia tora seeds affected hypercholesterolemic rats lipid profiles for eight weeks. Thirty six adult male rats were divided into two main groups. The first main group (six rats) were fed a regular diet and used (- ve control group). The second main group of 30 rats, fed on a high- cholesterol diet to induce hypercholesterolemia for 7 weeks, then was divided into five subgroups as follows: Subgroup (1) was fed a high- cholesterol diet and used as a positive control group. Subgroup (2 and 3) were given high- cholesterol diets that included supplements of 5% and 10% Gb leaves powder, respectively. Subgroup (4 and 5) were given high- cholesterol diets that included supplements of 5% and 10% powder from C. tora seeds, respectively. According to the obtained findings, liver enzymes, kidney functions and lipid profile were found to be significantly decreased (P≤0.05) while, HDL- C was noticeably increased by Gb leaves or C. tora seeds at the tested levels as compared to the positive control group. Furthermore, significantly increased in antioxidant enzymes (SOD and CAT) while, a decrease in MDA by Gb leaves or C. tora seeds supplementation at the tested levels in hypercholesterolemic rats. In conclusion that Gb leaves or C. tora seeds significantly reduced cholesterol levels while also improved liver enzymes, kidney functions and antioxidant enzyme. Therefore, Gb leaves or C. tora seeds may be recommended for hypercholesterolemic patients.

Previous studies showed the link between hyperhomocysteinemia (HHcy), dyslipidemia, and Atherosclerosis among End stage renal disease. However, there was limited epidemic data concerning Sudanese patient and risk associated with hyperhomocsteinemia. This study aims to investigate the association of plasma homocysteine (Hcy) level with lipid profiles in End stage renal disease compare to control group. A total of 120 Sudanese subjects from a cohort of the Khartoum state were included in the analysis. Plasma total Hcy, serum lipid files including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were measured to evaluate associations of Hcy and lipid profiles in ESRD and control group. Subjects were 47.18 ± 8.91 years old, and 58.33% were male. Median Hcy was 21.85 ± 1.8 μmol/L for patients, and 12.11± 0.9 for healthy individuals. HHcy was associated with increasing risk of low HDL-C (HDL-C < 50 mg/dL; and hypertriglyceridemia (TG ≥ 150 mg/dL, there were significant different association between HHcy and TC or LDL-C. The present study showed that HHcy was associated with hypertriglyceridemia and low levels of HDL-C in end stage renal disease compare to healthy individual group, which provides evidence that Hcy levels might affect HDL-C and TG metabolism and may increase risk factor for developing cardiovascular diseases.

The aim of this study is to assess the impact of vitamin D deficiency on lipid profile among patients. The study included 71 patients, 30 healthy patients classified as controls and 41 patients suffering from vitamin D deficiency classified as the case group. Vitamin D levels were stratified into three ranges: deficient (<10 ng/ml), insufficient (10-20 ng/ml), and sufficient (>20 ng/ml) among which there was high significant difference among the levels of cholesterol (TC), and triglycerides (TG) between cases and controls, and there was no significant difference in levels of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and TG: HDL-C ratio between cases and controls. We found insignificantly negative correlation between the serum levels of total cholesterol, triglycerides, HDL-C and TG: HDL-C ratio, and vitamin D, in addition to insignificantly positive correlation between LDL-C level and vitamin D. The study concluded that serum cholesterol and triglycerides were significantly higher among patients suffering from vitamin D deficiency compared to control. Hypercholesterolemia and hypertriglyceridemia increased risk of Dyslipidemia like atherosclerosis, coronary artery disease (CAD), coronary heart disease, and cerebral ischemic.

Background: Blood pressure and lipid profile are two tests used to determine the health level of individuals. The previous studies have found a positive correlation between high fruits and vegetable diets and decrease the incidence of hypertension, cardiovascular diseases compared to general populations. Objective: To compare the blood pressure and lipid profile in semi- vegetarians people and the general population. Methods: A Cross-Sectional Study which conducted 60 random samples was divided into two groups the first group consisted of 30 samples of people semi-vegetarians and the second group consisted of 30 samples of a general population, in both groups between the ages of 18-45 to measured blood pressure, and lipid profile. Results: There is no significant difference between semi-vegetarians and the general population in measuring the blood pressure and HDL. And we found a marked difference in TG, CL and LDL measurements In all instances, p > 0.05. Conclusion: From this study, it can be concluded that CL and TG and LDL level in the semi-vegetarians people less than people from the general population.