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如今,地图的用户需求、数据来源、设计方法、显示介质、服务程度等都在呼唤个性化。生物信息技术中的眼动追踪方法能够为揭示地图认知过程实时地提供定性和定量依据,从而对地图认知与设计研究提供参考。但目前国内还未见对个性化地图认知的眼动研究。

背景与目的研究乳腺癌患者化疗药物敏感性差异,探讨原代肿瘤细胞三维立体培养法化疗药物敏感性检测（CD-DST）在乳腺癌个体性化疗中的意义。 方法采用CD-DST法检测乳腺癌原发病灶肿瘤组织120例（粗针吸活检10例，手术110例）对5种乳腺癌常用化疗药物（紫杉醇、表阿霉素、5-氟尿嘧啶、顺铂、诺维本）的敏感性，观察检测成功率、患者问药物敏感性的个体差异及检测结果与临床应用效果的吻合度。

The study of animal personality has attracted considerable attention, as it has revealed a number of similarities in personality between humans and several nonhuman species. At the same time the adaptive value and evolutionary maintenance of different personalities are the subject of debate. Since Pavlov＇s work on dogs, students of comparative cognition have been aware that animals display vast individual differences on cognitive tasks, and that these differences may not be entirely accounted for differences in cognitive abilities. Here, we argue that personality is an important source of variation that may affect cognitive performance and we hypothesise mutual influences between personality and cognition across an individual＇s lifespan. In particular, we suggest that： 1） personality profiles may be markers of different cognitive styles; 2） success or failure in cognitive tasks could affect different personalities differently; 3） ontogenetic changes of personality profiles could be reflected in changes in cognitive performance. The study of such interplay has implications in animal welfare as well as in neuroscience and in translational medicine [Current Zoology 57 （4）： 491-498, 2011].

Consistent individual differences （CIDs） in behavior are of interest to both basic and applied research, because any selection acting on them could induce evolution of animal behavior. It has been suggested that CIDs in the behavior of fish might explain individual differences in vulnerability to fishing. If so, fishing could impose selection on fish behavior. In this study, we assessed boldness-indicating behaviors of Eurasian perch Perca fluviatilis using individually conducted experiments measuring the time taken to explore a novel arena containing predator （burbot, Lota Iota） cues. We studied if individual differences in boldness would explain vulnerability of individually tagged perch to experimental angling in outdoor ponds, or if fishing would impose selection on boldness-indicating behavior. Perch expressed repeatable individual differences in boldness-indicating behavior but the individual boldness-score （the first principal component） obtained using principal component analysis combining all the measured behavioral responses did not explain vulnerability to experimental angling. Instead, large body size appeared as the only statistically significant predictor of capture probability. Our results suggest that angling is selective for large size, but not always selective for high boldness.

Vocal individuality is widespread in social animals. Individual variation in vocalizations is a prereq- uisite for discriminating among conspecifics and may have facilitated the evolution of large complex societies. Ring-tailed lemurs Lemur catta live in relatively large social groups, have con- spicuous vocal repertoires, and their species-specific utterances can be interpreted in light of source-filter theory of vocal production. Indeed, their utterances allow individual discrimination and even recognition thanks to the resonance frequencies of the vocal tract. The purpose of this study is to determine which distinctive vocal features can be derived from the morphology of the upper vocal tract. To accomplish this, we built computational models derived from anatomical measurements collected on lemur cadavers and compared the results with the spectrographic out- put of vocalizations recorded from ex situ live individuals. Our results demonstrate that the mor- phological variation of the ring-tailed lemur vocal tract explains individual distinctiveness of their species-specific utterances. We also provide further evidence that vocal tract modeling is a power- ful tool for studying the vocal output of non-human primates.

Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia.

The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan （PC6） with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. In- teractions between frequency and duration play a critical role in quantified acupuncture therapy.

This article presents a gaze estimation method （GEMHSSO） based on the pupil center cornea reflection （PCCR） technique. Existing PCCR systems suffer from several problems, including the restriction of users＇ head movement, and the requirement of individual calibration. This paper presents a head position compensation model using a single camera and a single light source, which realizes the analytic compensation of head motion effects on pupil-glint vectors. We then present a transformation model for individual differences to simplify the calibration process to a one-point calibration. On this basis, we establish a novel gaze estimation method that reduces the minimum hardware requirements for accurate estimation to a single camera （not calibrated） and a single light source. Without the need for a complex system, our method has the ability to estimate gaze during natural head movement, and to substantially simplify user calibration. Each step of the proposed method in this paper makes real-time implementation possible, which provides an effective solution for eye-gaze tracking in human-computer interaction systems.

Based on monthly mean surface air temperature （SAT） from 71 stations in northern China and NCEP/ NCAR and NOAA-CIRES （Cooperative Institute for Research in Environmental Sciences） twentieth century reanalysis data, the dominant modes of winter SAT over northem China were explored. The results showed that there are two modes that account for a majority of the total variance over northern China. The first mode is unanimously colder （warmer） over the whole of northern China. The second mode is characterized by a dipole structure that is colder （warmer） over Northwest China （NWC） and warmer （colder） over Northeast China （NEC）, accounting for a fairly large proportion of the total variance. The two components constituting the second mode, the individual variations of winter SAT over NWC and NEC and their respective preceding factors, were further investigated. It was found that the autumn SAT anomalies are closely linked to persistent snow cover anomalies over Eurasia, showing the delayed effects on winter climate over northern China. Specifically, the previous autumn SAT anomalies over the Lake Baikal （LB; 50-60°N, 85-120°E） and Mongolian Plateau （MP; 42-52°N, 80-120°E） regions play an important role in adjusting the variations of winter SAT over NWC and NEC, respectively. The previous autumn SAT anomaly over the MP region may exert an influence on the winter SAT over NEC through modulating the strength and location of the East Asian major trough. The previous autumn SAT over the LB region may modulate winter westerlies at the middle and high latitudes of Asia and accordingly affects the invasion of cold air and associated winter SAT over NWC.