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目的比较磁共振血管造影(MRA)改良脑梗死溶栓血流分级(m TICI)与经颅多普勒超声(TCD)脑缺血溶栓血流分级(TIBI)对静脉溶栓后血管再通评价的一致性,并探讨其临床应用价值。方法选择重组组织型纤溶酶原激活物阿替普酶静脉溶栓治疗大脑中动脉主干、基底动脉狭窄或闭塞的急性缺血性卒中患者共61例,分别于溶栓治疗前、治疗后24 h进行MRA和TCD检查,并验证m TICI和TIBI分级系统对血管闭塞和再通评价结果的一致性。结果溶栓治疗前m TICI和TIBI分级分别显示血管闭塞者为49例(80.33%)和45例(73.77%;κ=0.816,P=0.000);溶栓治疗后24 h,m TICI和TIBI分级显示闭塞动脉完全再通者为9例(14.75%)和11例(18.03%)、部分再通者为18例(29.51%)和17例(27.87%),血管再通总数(包括完全再通和部分再通)分别为27例(44.26%)和28例(45.90%;κ=0.917,P=0.000)。结论 TCD TIBI分级系统与MRA m TICI分级系统对急性缺血性卒中患者溶栓治疗前大动脉血管狭窄或闭塞的诊断和溶栓治疗后血管再通的评价,具有较高的一致性,二者相比,前者更具有检查灵活、方便、经济、可重复施行及床旁长时间监测等优势,值得进一步深入研究,以促进其在溶栓治疗过程中的广泛应用。

Direct reduction of high-phosphorus oolitic hematite ore based on biomass pyrolysis gases （CO, H2, and CH4 ）, tar, and char was conducted to investigate the effects of reduction temperature, iron ore-biomass mass ratio, and reduction time on the metallization rate. In addition, the effect of particle size on the dephosphorization and iron recovery rate was studied by magnetic separation. It was determined that the metallization rate of the hematite ore could reach 99.35 % at iron ore-biomass mass ratio of 1 ： 0.6, reduction temperature of 1100℃, and reduction time of 55 min. The metallization rate and the aggregation degree of iron particles increase with the increase of reduction temperature. The particle size of direct reduced iron （DRI） has a great influence on the quality of the iron concentrate during magnetic separation. The separation degree of slag and iron was improved by the addition of 15 mass% sodium carbonate. DRI with iron grade of 89.11%, iron recovery rate of 83.47%, and phosphorus content of 0.28% can be obtained when ore fines with particle size of -10μm account for 78.15%.

A set of improved and efficient radiation parameterization schemes for surface radiation balance components under clear- sky conditions was developed by using general surface measurements and MODIS data. The set of schemes was then adapted for regions similar to the present study sites under different grazing intensities and varying degrees of drought in the semiarid grasslands of Inner Mongolia. Specifically, we mainly improved two schemes for estimating downward shortwave and longwave radiation at the surface, which could be applied to regions with certain degrees of drought. The validation datasets were from ground-based observations at various grazing sites during the growing season （May to September） of different drought years, 2005 and 2006. Through comparisons of parameterized versus measured radiation values, the increased or modified factors in the original schemes demonstrated improved estimation accuracy, and the rationalities of input parameters and variables were analyzed. The regional instantaneous net radiation estimations had root-mean-square errors of less than 30 W m-2 compared with ground measurements at the sites during the study period. The statistical results showed the improved schemes are suitable for estimating surface net radiation in regional semiarid areas during the growing season. Analyses of the sensitivity of the schemes to corresponding variables were conducted to ascertain the major error sources of the schemes and potential variables for improving the performance of the schemes in agreement with observations.

In this study, we investigated whether a single nucleotide polymorphism （rs42524 G 〉 C） in the type I alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G 〉 C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC ＋ CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was 〉 3. In addition, the rs42524 G 〉 C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type I alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.

Harmful algal blooms （HABs） have been affecting negatively the shellfish and aquaculture industries around the world. Though a lot of efforts have been made to disclose the changes of environmental factors involved and their effects on the HABs events, the molecular mechanism of this process remains unclear. To address this problem, proliferating cell nuclear antigen gene （pcna） was isolated and characterized from Alexandrium catenella. It showed high homology to those of other dinoflagellates （89% and 91% homology to Pfiesteria piscicid and Pyrocystis lunula, respectively）, and also 42%–43% homology to those of plant and animals. The expression level of pcna revealed by quantitative real time PCR was the lowest at the late lagging cell growth phase, increased to the highest at the late exponential phase, and then decreased at the stationary phase. Though the cell growth rate was also changing, no positive correlation between pcna expression level and cell growth rate was displayed throughout the whole cell growth stages （r 2 =0.024 6）. However, the pcna expression level had the similar trend with the change of cell growth rate throughout the whole growing process, e.g., from increasing at the earlier cell growth stage to decreasing at the following stages, though slightly lagging to the latter.

探讨经额定位穿刺术治疗颅内深部血肿的临床疗效。37例基底节出血患者经CT精确定位后经额穿刺抽吸血肿,并向血肿腔内注射尿激酶30×103U以促进血肿液化排出。术后CT显示定位满意,引流3~7 d后血肿清除率超过75%。术后2例死于并发症、2例重残、3例再出血,共33例患者预后良好。表明CT定位方法无需复杂设备,操作简便、定位准确、临床疗效显著,适用于基层医院推广应用。

臺灣地區原住民比率最高、社經背景最低落，且基測成績最差的臺東縣，原漢族群與家庭背景對高中職入學考試基測成績，以及是否升學與所升上的教育分流有何影響？非常值得探討，然而，研究者未見國內有關這方面的研究。本研究根據「臺東縣教育長期資料庫」所蒐集的2006年高中職入學考試基測成績與升學結果資料做分析。研究結果顯示：雖然整體升學率已接近100%，不同出身背景者幾乎都能升學而没多大不同，可是漢人升上出路最佳的公立高中比率仍比原住民高出許多，原住民學生升上出路最差的私立高職比率仍較漢人高出許多。原住民在入學考試雖享有加分三分之一的優待，不過由於原始成績低於漢人許多，加分後的成績與所升上教育分流的出路仍比漢人差了不少；而原住民成績比漢人低許多，重要原因是家庭背景較差。