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为探究大熊猫源猫泛白细胞减少症病毒（Feline panleukopenia virus， FPV）流行毒株的分子流行特征，本研究对一例腹泻大熊猫（Ailuropoda melanoleuca）粪便样本进行检测。通过PCR成功扩增并测定了FPV VP2基因全长序列（命名为Giant panda/AB/2025）。遗传进化分析显示，该毒株属于FPV G1基因型，与FPV参考毒株核苷酸同源性为99.2%～99.9%，与研究团队2018年分离的大熊猫源FPV株同源性可达99.4%。关键氨基酸位点分析发现，决定宿主特异性的位点（80、93、103、323、564和568）均与典型FPV一致，但其91位氨基酸由A突变为S（A91S）。蛋白3D结构模型预测显示，A91S突变导致VP2蛋白表面Loop区局部构象改变。结果表明，我国部分地区的大熊猫种群中已存在携带A91S突变的FPV变异株感染，需加强持续监测。本研究结果为大熊猫FPV的流行病学和疫苗研发提供了数据参考。

目的探讨抑郁症患者抗抑郁剂治疗与白细胞减少的关系。方法病例组为符合《中国精神障碍分类与诊断标准（第3版）》（CCMD-3）的抑郁症患者，入组后分别予艾司西酞普兰、帕罗西汀、米氮平、舍曲林单药治疗4周，采用血细胞分析仪分别测定正常对照组及病例组治疗前、治疗2周、治疗4周的白细胞及中性粒细胞计数。结果对照组与病例组治疗前白细胞、中性粒细胞计数差异无统计学意义（P〉0．05）；艾司西酞普兰组治疗前与治疗4周中性粒细胞计数分别为（3．75±1．30）＊10^9／L、（3．34±1．12）＊10^9／L，差异有统计学意义（t=2．16，P=0．03）；其余病例组治疗前后白细胞、中性粒细胞计数比较差异无统计学意义（P〉0．05）。结论艾司西酞普兰可能在一定程度上降低抑郁症患者中性粒细胞数量。

患者,女性,17岁,因“厌食3+年,情绪低落7+月,伴暴食、催吐4+月”入院。3+年前患者因便秘开始逐渐减少食量,以减少主食及肉类为主,体质量逐渐减轻,患者观念随即改变,认为越瘦越美,每日吃很少的主食,几乎不吃肉类及油腻食物,计算摄入的热量。患者十分关注自己的体重,每日多次照镜子。1+年前患者体质量较节食前减轻约15kg,虽然已经很瘦,但仍认为自己很胖,认为吃下去的东西全都变成脂肪长在了身上。

目的 Graves病(Graves disease，GD)的临床表现并不局限于甲状腺，而是表现为多器官脏器的损害，其中对血液系统的影响表现为白细胞总数和粒细胞数目的减少。抗甲状腺药物他巴陛在临床上广泛地用于治疗GD，但接受治疗的患者中0．1％-0．3％可发生粒细胞缺乏，白细胞总数和粒细胞数目的减少则更为多见。白细胞减少的初期，患者往往无自觉症状，一旦发生感染，则广泛且难以控制，是GD致死的主要原因之一。因此，深入进行GD白细胞减少发病机制的研究，具有重要意义。本研究探讨天津地区汉族人GD白细胞减少易感性与HLA-DRB1基因多态性的关联，以便早期发现易感者，严密监测，争取做到早期诊断、早期治疗。方法采用聚合酶链反应—序列特异性引物(PCR—SSP)方法检测50例GD白细胞减少患者、50例GD白细胞正常患者和90名正常对照的HLA-DRB1基因型，计算并比较GD白细胞减少组与GD白细胞正常组和对照组的HLA-DRB1等位基因频率。结果 ①在不考虑白细胞变化的情况下，GD患者DRB1*08基因频率明显高于对照组(P＜0．0l，RR＝2．97)，DBBl*07基因频率明显低于对照组(P＜0．0l，RR＝0．22)。②GD白细胞减少组DRB1*08(P＜0．0l，RR＝5．36)和DRB1*15(P＜0．05，RR＝1．87)基因频率较对照组显著增高，DBBl*07基因频率明显低于对照组(P＜0．0l，RR＝0．13).(3)GD白细胞减少组DBBl*08基因频率(P＜0．01)和DBBl*15基因频率(P＜0．05)均明显高于白细胞正常组，DRB1*09基因频率(P＜0．05)明显低于白细胞正常组。结论:天津地区汉族GD白细胞减少易感性与HLA-DRB1*08，HLA-DRB1*15基因频率增加有关；GD的保护性与HLA-DRB1*07基因频率减少有关。

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肺癌是威胁人类健康最常见的实体肿瘤，在许多国家其发病率和死亡率都处于急剧增长的趋势，在我国一些大城市和工矿地区已占恶性肿瘤的首位。肺癌患者由于肺功能受损、细胞免疫功能降低、放化疗所致白细胞减少、广谱抗生素的使用以及各种侵入性的治疗，极易发生肺部真菌感染。文献报道有11．6％的恶性肿瘤患者并发医院内真菌感染，而肺部感染占其中的23．1％。我们采用回顾性调查方法，对我科2001年1月1日至2004年6月30日间收治的258例肺癌患者中继发肺部真菌感染进行分析，现将分析结果及护理措施报告如下。

Severe fever with thrombocytopenia syndrome （SFTS） is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus, SFTSV, named after the disease. The transmission vectors and animal hosts of SFTSV are unclear. Ticks are the most likely transmission vectors and domestic animals, including goats, dogs, and cattle, are potential amplifying hosts of SFTSV. The clinical symptoms of SFTS are nonspecific, but major symptoms include fever, gastrointestinal symptoms, myalgia, dizziness, joint pain, chills, and regional lymphadenopathy. The most common abnormalities in laboratory test results are thrombocytopenia （95%）, leukocytopenia （86%）, and elevated levels of serum alanine aminotransferase, aspartate ami- notransferase, creatine kinase, and lactate dehydrogenase. The fatality rate for SFTS is 12% on average, and the annual inci- dence of the disease is approximately five per 100000 of the rural population.

Objective： Chemotherapy is the standard treatment for small-cell lung cancer （SCLC）, and leukopenia is a common side effect. This study assesses whether chemotherapy-induced leukopenia is a predictor of efficacy and whether it is associated with the survival of SCLC patients. Methods： A retrospective analysis was conducted on data from 445 patients with SCLC who received standard chemotherapy for 4 to 10 cycles. The World Health Organization grading system classifies leukopenia during chemotherapy as follows： absent （grade 0）, mild （grades 1 and 2）, or severe （grades 3 and 4）. The primary endpoint is overall survival （OS）. Results： The association between chemotherapy-induced leukopenia and OS was assessed. According to a multivariate Cox model with time-varying covariates, the hazard ratio of death was significantly lower among patients with mild leukopenia than among patients with severe leukopenia at 0.687 （0.506 to 0.943） and 1.414 （1.147 to 1.744）, respectively. The median survival was 13 months （95% CI： 11 to 15 months） for patients who did not experience leukopenia, 17 months （95% CI： 14 to 18 months） for those with mild leukopenia, and 14 months （95% CI： 13 to 16 months） for those with severe leukopenia （absent vs. mild vs. severe leukopenia, P=0.047）. Conclusion： Leukopenia during chemotherapy is associated with the survival of SCLC patients. Mild leukopenia is strongly associated with longer survival time.

Using a 1.5-layer reduced-gravity nonlinear shallow-water equation model, we studied the effect of the meridional wind on the western boundary currents (WBC) at critical states with hysteresis courses. The results of the simulation indicate that the WBC is prone to penetrating into the gap under northerly winds, and its path is more difficult to alter due to the larger interval between the two critical transition curves (C1P and C1L). For southerly winds, the WBC is prone to leaping across the gap, and its path is easier to alter due to the smaller interval between the two critical transition curves. The simulation results also indicate that the meridional winds over the southern region of the gap are the dominant factor determining the formation of the WBC. The dynamic mechanism influencing the transport of WBC near the gap is both Ekman transport and the blocking of Ekman transport. Ekman transport induced by northerly winds may reduce the transport of the WBC, causing the β-effect to dominate the meridional advection (promoting the penetration). Southerly winds, however, may enhance the transport of the WBC, causing the meridional advection to dominate the β-effect (promoting the leaping state). These results explain some structural features of the Kuroshio at the Luzon Strait.