Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
17,782
result(s) for
"39"
Sort by:
Cargo recognition and degradation by selective autophagy
Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past three decades, selective autophagy has been characterized as a highly regulated and specific degradation pathway for removal of unwanted cytosolic components and damaged and/or superfluous organelles. Here, we discuss different types of selective autophagy, emphasizing the role of ligand receptors and scaffold proteins in providing cargo specificity, and highlight unanswered questions in the field.
In this Review Article, Klionsky and co-authors discuss selective autophagy pathways that degrade unwanted cytosolic components and organelles, and how these pathways require ligand receptors and scaffold proteins for cargo specificity.
Journal Article
Anatomizing Civil War : studies in Lucan's epic technique
\" Imperial Latin epic has seen a renaissance of scholarly interest. This book illuminates the work of the poet Lucan, a contemporary of the emperor Nero. This maverick but socially prominent poet, whom Nero commanded to commit suicide at the age of 26, left an epic poem on the civil war between Caesar and Pompey that epitomizes the exuberance and stylistic experimentation of Neronian culture. This study focuses on Lucan's epic technique and traces his influence through the Middle Ages and the Renaissance. Martin Dinter's newest volume engages with Lucan's use of body imagery, sententiae, Fama (rumor), and open-endedness throughout his civil war epic. Although Lucan's Bellum Civile is frequently decried as a fragmented as well as fragmentary epic, this study demonstrates how Lucan uses devices other than teleology and cohesive narrative structure to bind together the many parts of his epic body. Anatomizing Civil War places at center stage characteristics of Lucan's work that have so far been interpreted as excessive, or as symptoms of an overly rhetorical culture indicating a lack of substance. By demonstrating that they all contribute to Lucan's poetic technique, Martin Dinter shows how they play a fundamental role in shaping and connecting the many episodes of the Bellum Civile that constitute Lucan's epic body. This important volume will be of interest to students of classics and comparative literature as well as literary scholars. All Greek and Latin passages have been translated\"-- Provided by publisher.
BOOK
Mechanistic insights into selective autophagy pathways: lessons from yeast
Key Points
Both general and selective autophagy are critical regulators of cellular homeostasis with intricate links to cell metabolism, growth control, the balance between cell survival and cell death, as well as ageing. Not surprisingly these autophagy pathways also have important roles in human health and disease.
Selective autophagy requires, in addition to the core autophagy machinery, one or more selectivity factors, the most important of which are the selective autophagy receptors, which tag the specific cargo for engulfment in an autophagosome and delivery to the lysosome (vacuole in yeast and plants). Each pathway may use one or more such receptors.
Although the selectivity factors required for the plethora of selective autophagy pathways are not highly conserved, their mechanisms of activation and the signalling pathways that activate them are.
Selective autophagy receptors are regulated by phosphorylation by protein kinases.
Phosphorylation of the selective autophagy receptors regulates their ability to recruit and engage other components of the core autophagy machinery for phagophore membrane expansion around the selective cargo.
Selective autophagy pathways engage selective autophagy receptors (SARs) that identify and bind to cellular cargoes (proteins or organelles) destined for degradation. Recent yeast studies have provided insights into the regulation and mechanisms underlying SAR function. As these mechanisms are conserved from yeast to mammals, it is now possible to formulate general principles of how selectivity during autophagy is achieved.
Autophagy has burgeoned rapidly as a field of study because of its evolutionary conservation, the diversity of intracellular cargoes degraded and recycled by this machinery, the mechanisms involved, as well as its physiological relevance to human health and disease. This self-eating process was initially viewed as a non-selective mechanism used by eukaryotic cells to degrade and recycle macromolecules in response to stress; we now know that various cellular constituents, as well as pathogens, can also undergo selective autophagy. In contrast to non-selective autophagy, selective autophagy pathways rely on a plethora of selective autophagy receptors (SARs) that recognize and direct intracellular protein aggregates, organelles and pathogens for specific degradation. Although SARs themselves are not highly conserved, their modes of action and the signalling cascades that activate and regulate them are. Recent yeast studies have provided novel mechanistic insights into selective autophagy pathways, revealing principles of how various cargoes can be marked and targeted for selective degradation.
Journal Article
V-ATPase-dependent induction of selective autophagy
The general consensus is that the vacuolar-type H
+
-translocating ATPase (V-ATPase) is critical for macroautophagy/autophagy. However, there is a fundamental conundrum because follicular lymphoma-associated mutations in the V-ATPase result in lysosomal/vacuolar deacidification but elevated autophagy activity under nutrient-replete conditions and the underlying mechanisms remain unclear. Here, working in yeast, we show that V-ATPase dysfunction activates a selective autophagy flux termed “V-ATPase-dependent autophagy “. By combining transcriptomic and proteomic profiling, along with genome-wide suppressor screening approaches, we found that V-ATPase-dependent autophagy is regulated through a unique mechanism distinct from classical nitrogen starvation-induced autophagy. Tryptophan metabolism negatively regulates V-ATPase-dependent autophagy via two parallel effectors. On the one hand, it activates ribosome biogenesis, thus repressing the translation of the transcription factor Gcn4/ATF4. On the other hand, tryptophan fuels NAD
+
de novo biosynthesis to inhibit autophagy. These results provide an explanation for the mutational activation of autophagy seen in follicular lymphoma patients.
Here the authors show that mutations in V-ATPase genes in follicular lymphoma trigger V-ATPase-dependent autophagy. This process, linked to tryptophan metabolism and ribosome biogenesis, may help tumor cells thrive under stress conditions.
Journal Article
Life, death and autophagy
Autophagy influences cell survival through maintenance of cell bioenergetics and clearance of protein aggregates and damaged organelles. Several lines of evidence indicate that autophagy is a multifaceted regulator of cell death, but controversy exists over whether autophagy alone can drive cell death under physiologically relevant circumstances. Here, we review the role of autophagy in cell death and examine how autophagy interfaces with other forms of cell death including apoptosis and necrosis.
In this Review, Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival and cell death. They cover the interplay between autophagy, apoptosis and necrosis, as well as engulfment and inflammation.
Journal Article
A brief history of autophagy from cell biology to physiology and disease
The field of autophagy research has developed rapidly since the first description of the process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is now increasingly studied at the level of organismal pathophysiology and is being connected to the medical sciences. This Historical Perspective describes a brief history of autophagy and discusses unanswered cell biological questions in the field.
A history of autophagy. In this Perspective, Mizushima describes the leaps and bounds in the history of autophagy and discusses unanswered questions driving the field forward.
Journal Article
Autophagy and disease: unanswered questions
Autophagy is a process in which intracellular components and dysfunctional organelles are delivered to the lysosome for degradation and recycling. Autophagy has various connections to a large number of human diseases, as its functions are essential for cell survival, bioenergetic homeostasis, organism development, and cell death regulation. In the past two decades, substantial effort has been made to identify the roles of autophagy in tumor suppression and promotion, neurodegenerative disorders, and other pathophysiologies. This review summarizes the current advances and discusses the unanswered questions in understanding the involvement of autophagy in pathogenic mechanisms of disease, primarily focusing on cancer and neurodegenerative diseases.
Journal Article