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In this study, we elucidate the effect of different sonication techniques to efficiently prepare particle dispersions from selected non-functionalized NPs (Cu, Al, Mn, ZnO), and corresponding consequences on the particle dose, surface charge and release of metals. Probe sonication was shown to be the preferred method for dispersing non-inert, non-functionalized metal NPs (Cu, Mn, Al). However, rapid sedimentation during sonication resulted in differences between the real and the administered doses in the order of 30–80 % when sonicating in 1 and 2.56 g/L NP stock solutions. After sonication, extensive agglomeration of the metal NPs resulted in rapid sedimentation of all particles. DLVO calculations supported these findings, showing the strong van der Waals forces of the metal NPs to result in significant NP agglomeration. Metal release from the metal NPs was slightly increased by increased sonication. The addition of a stabilizing agent (bovine serum albumin) had an accelerating effect on the release of metals in sonicated solutions. For Cu and Mn NPs, the extent of particle dissolution increased from <1.6 to ~5 % after sonication for 15 min. A prolonged sonication time (3–15 min) had negligible effects on the zeta potential of the studied NPs. In all, it is shown that it is of utmost importance to carefully investigate how sonication influences the physico-chemical properties of dispersed metal NPs. This should be considered in nanotoxicology investigations of metal NPs. Graphical Abstract

The sales-related difficulties faced by cooperatives can be solved by expanding their sales channels through e-commerce. However, extant studies have only examined cooperatives’ e-commerce sales behavior from either a technology perception or government support perspective. To fill this gap, based on survey data of 215 farmer cooperatives in Liaoning province, China, this study employs a probit model to analyze the impact of both technology perception and government support on these cooperatives’ e-commerce sales behavior, as well as their marginal and accelerating effects. Both factors were shown to have a significant positive impact. Technology perception has a greater impact on e-commerce sales behavior than government support, while perceived effectiveness has the most significant impact. This study also found that government support has an accelerating effect on the relationship between technology perception and farmer cooperatives’ e-commerce sales behavior. Therefore, governments should improve cooperative members’ technology perception to aid them in expanding sales.

CD55 prevents convertase enzyme formation in the complement cascade, acting as a brake on complement activation. Inactivating mutations in CD55 result in hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy.

This article presents recent research on cements containing GGBFS and their modifications with accelerating admixtures. The initial setting time and hydration heat evolution results are presented for cement CEM II/B-S and CEM III/A manufactured with three Portland clinkers of various phase compositions. The research was carried out at 8 °C and 20 °C. The main objective is to assess the behavior of blended cements in cooperation with modern admixtures that contain nucleation seeds. The authors aimed to compare and evaluate different methods to reduce setting time, namely, the effects of temperature, the specific surface area of cement and GGBFS, the type of Portland clinker, the content of GGBFS, and presence of accelerators. Many of these aspects appear in separate studies, and the authors wanted a more comprehensive coverage of the subject. Those methods of reducing the setting time can be ranked: the most effective is to increase the temperature of the ingredients and the surroundings, the second is to reduce the GGBFS content in cement, and the use of accelerators, and the least effective is the additional milling of Portland clinker. However, of these methods, only the use of accelerators is acceptable in terms of sustainability. Prospective research is a detailed study on the amounts of C-S-H phase and portlandite to determine the hydration rate.

Edge states emerging at the boundaries of materials with nontrivial topology are attractive for many practical applications due to their remarkable robustness to disorder and local boundary deformations, which cannot result in scattering of the energy of the edge states impinging on such defects into the bulk of material, as long as forbidden topological gap remains open in its spectrum. The velocity of such states traveling along the edge of the topological insulator is typically determined by their Bloch momentum. In contrast, here, using valley Hall edge states forming at the domain wall between two honeycomb lattices with broken inversion symmetry, we show that by imposing Airy envelope on them one can construct edge states which, on the one hand, exhibit along the boundary of the insulator despite their fixed Bloch momentum and, on the other hand, along the boundary despite the presence of localized features in their shapes. We construct both linear and nonlinear self-accelerating edge states, and show that nonlinearity considerably affects their envelopes. Such self-accelerating edge states exhibit self-healing properties typical for nondiffracting beams. Self-accelerating valley Hall edge states can circumvent sharp corners, provided the oscillating tail of the self-accelerating topological state is properly apodized by using an exponential function. Our findings open new prospects for control of propagation dynamics of edge excitations in topological insulators and allow to study rich phenomena that may occur upon interactions of nonlinear envelope topological states.

Complement activation as an early and important inflammatory process contributes to multiple organ dysfunction after trauma. We have recently shown that complement inhibition by decay-accelerating factor (DAF) protects brain from blast-overpressure (BOP)-induced damage. This study was conducted to determine the effect of DAF on acute lung injury induced by BOP exposure and to elucidate its possible mechanisms of action. Anesthetized adult male Sprague-Daley rats were exposed to BOP (120 kPa) from a compressed air-driven shock tube. Rats were randomly assigned to three experimental groups: 1) Control (no BOP and no DAF treatment), 2) BOP (120 kPa BOP exposure), and 3) BOP followed by treatment with rhDAF (500μg/kg, i.v) at 30 minutes after blast. After a recovery period of 3, 24, or 48 hours, animals were euthanized followed by the collection of blood and tissues at each time point. Samples were subjected to the assessment of cytokines and histopathology as well as for the interaction of high-mobility-group box 1 (HMGB1) protein, NF-κB, receptor for advanced glycation end products (RAGE), C3a, and C3aR. BOP exposure significantly increased in the production of systemic pro- and anti-inflammatory cytokines, and obvious pathological changes as characterized by pulmonary edema, inflammation, endothelial damage and hemorrhage in the lungs. These alterations were ameliorated by early administration of rhDAF. The rhDAF treatment not only significantly reduced the expression levels of HMGB1, RAGE, NF-κB, C3a, and C3aR, but also reversed the interaction of C3a-C3aR and nuclear translocation of HMGB1 in the lungs. Our findings indicate that early administration of DAF efficiently inhibits systemic and local inflammation, and mitigates blast-induced lung injury. The underlying mechanism might be attributed to its potential modulation of C3a-C3aR-HMGB1-transcriptional factor axis. Therefore, complement and/or HMGB1 may be potential therapeutic targets in amelioration of acute lung injury after blast injury.

Wildfires often exhibit complex and dynamic behaviour arising from interactions between the fire and surrounding environment that can create a rapid fire advance and result in loss of containment and critical fire safety concerns. A series of laboratory experiments involving the interaction of two parallel fire lines on a uniform fuel bed without slope under the influence of wind is presented and discussed. The two fire lines are initially separated by a certain distance (1, 2 m) and the subsequent fire spread is described. The results show that the pyroconvective interaction between the two fire lines and ambient wind modified the rate of spread of the approaching fire lines and their associated spread characteristics, independently of the distance between them. A physical interpretation of fire evolution based on the dynamic interaction between two parallel fire lines under wind flow is proposed. We use a dimensionless physical parameter, the Froude number. The results also demonstrated the existence of a wind flow velocity between 1 and 2 m s−1, corresponding to a Froude number between 0.2 and 0.4 for which the rate of approach of the two merging fire lines is a minimum.

In this research, the degradation behavior and failure mechanism of silicone rubber seal rings under the synergistic effects of multiple factors in the marine atmosphere are fully investigated. Firstly, four aging factors of air, temperature, compressive stress, and chemical medium were determined by analyzing the service environment profile of silicone rubber seal under a marine atmosphere environment. Secondly, to better simulate the actual service environment of silicone rubber and shorten the test period, an artificially accelerated aging test was designed and carried out in the laboratory. In this paper, temperature is utilized as the accelerating stress. According to the results of the pre-test, the accelerating stress level is finally determined to be 110–150 ∘C. In addition, the compression set applied is consistent with the constant compression permanent deformation value of 28% of the silicone rubber in the actual service process. Finally, through the macroscopic physical properties and microstructure analysis of the samples before and after aging, the corresponding test results are given, and the failure mechanism is analyzed and discussed in detail. Through the above test results and discussion, it can be concluded that the aging process of multi-factor coupling on the lower silicone rubber seal ring is uneven, and its aging process is not a simple superposition of multiple environmental factors. More importantly, the above test data and results are of great significance for evaluating the service life of silicone rubber seals, which can be utilized in the future to improve the reliability and durability of related equipment in the marine environment.

This study investigated the thermal stability characteristics and developed a thermal explosion model for industrial-scale nitrocellulose (NC) using simultaneous thermal analysis, accelerating rate calorimeter (ARC) measurements, and kinetics data. The time to maximum rate under adiabatic conditions was approximately 35 min, and the adiabatic temperature rise recorded by the ARC was 70 °C, which indicated that the NC released considerable amounts of heat and gases in an extremely short time. Moreover, an autocatalytic kinetic model of NC decomposition was developed using nonisothermal differential scanning calorimetry data. The simulation results (of the thermal explosion model) were consistent with the experimental results (ARC data). Furthermore, the heat radiation effect of external fire sources on NC explosions was also investigated. This study aids the prevention and control of NC explosions and for the development of fire extinguishing technology.

Bee venom (BV)—a complex mixture of peptides and toxic proteins including phospholipase A2 and melittin—promotes blood clotting. In this study, we investigated the anti-atopic properties of BV and the mechanism associated with its regulation of the complement system. BV treatment upregulated the mRNA and protein levels of CD55 in THP-1 cells. Further experiments revealed that the phosphorylation of ERK was associated with upregulation of CD55. A complement-dependent cytotoxicity assay and a bacteria-killing assay showed that BV inactivated the complement system through the induction of CD55. The serum levels of C3 convertase (C3C) and Membrane attack complex (MAC) increased, while CD55 decreased in mice with AD-like lesions from DNCB treatment. However, the levels were inverted when the AD-like mice were treated with BV using subcutaneous injection, and we observed that the AD symptoms were alleviated. BV is often used to treat AD but its mechanism has not been elucidated. Here, we suggest that BV alleviates AD through the inactivation of the complement system, especially by the induction of CD55.