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CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

by Leavis, Helen L , Unlusoy Aksu, Aysel , Zhang, Yu , Domínguez Conde, Cecilia , Ozen, Ahmet , Baris, Zeren , Comrie, William A , Ogulur, Ismail , Sari, Sinan , Houwen, Roderick H.J , Matthews, Helen F , Ardy, Rico C , Morawski, Aaron R , Kiykim, Ayca , Beser, Ömer F , Su, Helen C , Ertem, Deniz , Ozcay, Figen , Kain, Renate , Pittaluga, Stefania , Erkan, Tülay , McElwee, Joshua J , Gulsan, Meltem , Karakoc-Aydiner, Elif , Boztug, Kaan , Dalgic, Buket , Baris, Safa , Serwas, Nina K , Tutar, Engin , Krolo, Ana , Folio, Les R , Snapper, Scott B , Lenardo, Michael J

in Age / Allergies / CD55 Antigens - blood / CD55 Antigens - genetics / Cell activation / Child / Child, Preschool / Complement activation / Complement Activation - drug effects / Complement Activation - genetics / Complement component C5a / Complement Inactivating Agents - pharmacology / Complement System Proteins - metabolism / Decay-accelerating factor / Diarrhea / Edema / Female / Gastroenterology / Gastrointestinal diseases / Gastrointestinal tract / Hepatology / Hereditary diseases / Heredity / Homeostasis / Homozygote / Humans / Immunoglobulin A - blood / Immunology / Infant / Infectious diseases / Inflammation / Intestine / Intestine, Small - pathology / Lymphatic system / Lymphocytes T / Malabsorption / Male / Medical research / Mutation / Pain / Pedigree / Protein deficiency / Protein-Losing Enteropathies - complications / Protein-Losing Enteropathies - genetics / Proteins / Statistics, Nonparametric / Syndrome / T-Lymphocytes - metabolism / Thromboembolism / Thrombosis / Thrombosis - genetics

2017

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CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

2017

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2017

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Journal Article

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

Leavis, Helen L,

Unlusoy Aksu, Aysel,

Zhang, Yu,

Domínguez Conde, Cecilia,

Ozen, Ahmet,

Baris, Zeren,

Comrie, William A,

Ogulur, Ismail,

Sari, Sinan,

Houwen, Roderick H.J,

Matthews, Helen F,

Ardy, Rico C,

Morawski, Aaron R,

Kiykim, Ayca,

Beser, Ömer F,

Su, Helen C,

Ertem, Deniz,

Ozcay, Figen,

Kain, Renate,

Pittaluga, Stefania,

Erkan, Tülay,

McElwee, Joshua J,

Gulsan, Meltem,

Karakoc-Aydiner, Elif,

Boztug, Kaan,

Dalgic, Buket,

Baris, Safa,

Serwas, Nina K,

Tutar, Engin,

Krolo, Ana,

Folio, Les R,

Snapper, Scott B,

Lenardo, Michael J

2017

Overview

CD55 prevents convertase enzyme formation in the complement cascade, acting as a brake on complement activation. Inactivating mutations in CD55 result in hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy.

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Publisher

Massachusetts Medical Society

Subject

Age

/ Allergies

/ CD55 Antigens - blood

/ CD55 Antigens - genetics

/ Cell activation

/ Child

/ Child, Preschool