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382,219 result(s) for "Biological research"
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Clarity Amidst Ambiguity: Towards Precise Definitions in Biological-Informed Disciplines for Enhanced Communication
This study conducts a meta-analysis of over 1000 abstracts to examine the use and consistency of the terminology in biomimetics, bioinspiration, biomimicry, and bionics, focusing on how these terms impact biological study design. Despite the increasing research in these areas, the ambiguous definitions of key terms complicate study design and interdisciplinary collaboration. The primary aim of this work is to analyse how biological studies in these fields are conceptualised and evaluated, particularly concerning the inconsistent use of terminology. By identifying discrepancies in term usage, we offer refined definitions and practical examples to improve the clarity of study design and research methodologies. Our findings underscore the importance of standardised terminology for ensuring that biological research is accurately designed and executed, leading to more rigorous experimental frameworks and better alignment across disciplines. This meta-analysis reveals how clearer, more consistent terminology can enhance study design in biologically inspired research fields.
TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines
TrackMate is an automated tracking software used to analyze bioimages and is distributed as a Fiji plugin. Here, we introduce a new version of TrackMate. TrackMate 7 is built to address the broad spectrum of modern challenges researchers face by integrating state-of-the-art segmentation algorithms into tracking pipelines. We illustrate qualitatively and quantitatively that these new capabilities function effectively across a wide range of bio-imaging experiments. TrackMate 7 combines the benefits of machine and deep learning-based image segmentation with accurate object tracking to enable improved 2D and 3D tracking of diverse objects in biological research.
DOME: recommendations for supervised machine learning validation in biology
DOME is a set of community-wide recommendations for reporting supervised machine learning–based analyses applied to biological studies. Broad adoption of these recommendations will help improve machine learning assessment and reproducibility.
At the poles
Examines the challenges scientists face while studying the polar regions and reasons why the work is important, and discusses living conditions, survival techniques, and the technology they use.
Promoting transparency and reproducibility in enhanced molecular simulations
The PLUMED consortium unifies developers and contributors to PLUMED, an open-source library for enhanced-sampling, free-energy calculations and the analysis of molecular dynamics simulations. Here, we outline our efforts to promote transparency and reproducibility by disseminating protocols for enhanced-sampling molecular simulations.
Fear nothing : a novel
While investigating the death of his mother who was a scientist, Chris Snow discovers she was engaged in secret experiments on a nearby military base, experiments which went wrong and which produced monsters. The next he knows, the monsters come visiting and they are not friendly.
Deciphering molecular interactions by proximity labeling
Many biological processes are executed and regulated through the molecular interactions of proteins and nucleic acids. Proximity labeling (PL) is a technology for tagging the endogenous interaction partners of specific protein ‘baits’, via genetic fusion to promiscuous enzymes that catalyze the generation of diffusible reactive species in living cells. Tagged molecules that interact with baits can then be enriched and identified by mass spectrometry or nucleic acid sequencing. Here we review the development of PL technologies and highlight studies that have applied PL to the discovery and analysis of molecular interactions. In particular, we focus on the use of PL for mapping protein–protein, protein–RNA and protein–DNA interactions in living cells and organisms.This Review describes proximity labeling methods that make use of peroxidases (APEX) or biotin ligases (TurboID, BioID), and their applications to studying protein–protein and protein–nucleic acid interactions in living systems.