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Colonialism
\"A book for middle school students about the political structure of colonialism.\"--Provided by publisher.
Book
Gender and empire
Focusing the perspectives of gender scholarship on the study of empire, this is a volume of insights about the conduct of men as well as women. Bringing together disparate fields — politics, medicine, sexuality, childhood, religion, migration, and many more topics — this collection of essays demonstrates the richness of studying empire through the lens of gender. This is a more inclusive look at empire, which asks not only why the empire was dominated by men, but how that domination affected the conduct of imperial politics.
eBook
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis
In patients with autoimmune pulmonary alveolar proteinosis, the use of inhaled recombinant granulocyte–macrophage colony-stimulating factor resulted in a significantly better alveolar–arterial oxygen gradient at 25 weeks than the use of placebo. The beneficial effect was not observed in smokers.
Journal Article
How the Spanish empire was built : a 400 year history
\"The untold story of the engineering behind the empire, showing how imperial Spain built upon existing infrastructure and hierarchies of the Inca, Aztec, and more, to further its growth. Sixteenth-century Spain was small, poor, disunited, and sparsely populated. Yet the Spaniards and their allies built the largest empire the world had ever seen. How did they achieve this? Felipe Fernández-Armesto and Manuel Lucena Giraldo argue that Spain's engineers were critical to this venture. The Spanish invested in infrastructure to the advantage of local power brokers, enhancing the abilities of incumbent elites to grow wealthy on trade, and widening the arc of Spanish influence. Bringing to life stories of engineers, prospectors, soldiers, and priests, the authors paint a vivid portrait of Spanish America in the age of conquest. This is a dazzling new history of the Spanish Empire, and a new understanding of empire itself, as a venture marked as much by collaboration as oppression\"-- Provided by publisher.
Book
Slavery and the Enlightenment in the British Atlantic, 1750–1807
This book examines the daily details of slave work routines and plantation agriculture in the eighteenth-century British Atlantic, focusing on case studies of large plantations in Barbados, Jamaica and Virginia. Work was the most important factor in the slaves' experience of the institution. Slaves' day-to-day work routines were shaped by plantation management strategies that drew on broader pan-Atlantic intellectual and cultural principles. Although scholars often associate the late eighteenth-century Enlightenment with the rise of notions of liberty and human rights and the dismantling of slavery, this book explores the dark side of the Enlightenment for plantation slaves. Many planters increased their slaves' workloads and employed supervisory technologies to increase labor discipline in ways that were consistent with the process of industrialization in Europe. British planters offered alternative visions of progress by embracing restrictions on freedom and seeing increasing labor discipline as central to the project of moral and economic improvement.
eBook
The starving empire : a history of famine in France's colonies
\"This book is a history of famine in the modern French Empire. It considers food crises in Algeria, West and Equatorial Africa, and Indochina to show how the French colonial state and the international community took increasing responsibility for subsistence, and ultimately failed to fulfill this responsibility\"-- Provided by publisher.
Book
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
Oncolytic viruses are under development for tumor treatment. David Kirn and colleagues now report their results of a randomized phase 2 dose-finding trial of JX-594, an oncolytic immunotherapeutic vaccinia virus, in patients with advanced hepatocellular carcinoma. The study shows that high-dose JX-594 was associated with significantly improved overall survival and induced radiographic responses and antitumor immunity.
Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an oncolytic and immunotherapeutic vaccinia virus. To determine the optimal JX-594 dose in subjects with advanced hepatocellular carcinoma (HCC), we conducted a randomized phase 2 dose-finding trial (
n
= 30). Radiologists infused low- or high-dose JX-594 into liver tumors (days 1, 15 and 29); infusions resulted in acute detectable intravascular JX-594 genomes. Objective intrahepatic Modified Response Evaluation Criteria in Solid Tumors (mRECIST) (15%) and Choi (62%) response rates and intrahepatic disease control (50%) were equivalent in injected and distant noninjected tumors at both doses. JX-594 replication and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression preceded the induction of anticancer immunity. In contrast to tumor response rate and immune endpoints, subject survival duration was significantly related to dose (median survival of 14.1 months compared to 6.7 months on the high and low dose, respectively; hazard ratio 0.39;
P
= 0.020). JX-594 demonstrated oncolytic and immunotherapy MOA, tumor responses and dose-related survival in individuals with HCC.
Journal Article
Global Calvinism
A comprehensive study of the connection between Calvinist
missions and Dutch imperial expansion during the early modern
period \"A tour de force offering the reader the
best study of global Calvinism in the realms of the Dutch East
India Company.\"-Ronnie Po-Chia Hsia, editor,
Calvinism and Religious Toleration in the Dutch Golden
Age Calvinism went global in the seventeenth and
eighteenth centuries, as close to a thousand Dutch Reformed
ministers, along with hundreds of lay chaplains, attached
themselves to the Dutch East India and West India companies. Across
Asia, Africa, and the Americas where the trading companies set up
operation, Dutch ministers sought to convert \"pagans,\" \"Moors,\"
Jews, and Catholics and to spread the cultural influence of
Protestant Christianity. As Dutch ministers labored under the
auspices of the trading companies, the missionary project
coalesced, sometimes grudgingly but often readily, with empire
building and mercantile capitalism. Simultaneously, Calvinism
became entangled with societies around the world as encounters with
indigenous societies shaped the development of European religious
and intellectual history. Though historians have traditionally
treated the Protestant and European expansion as unrelated
developments, the global reach of Dutch Calvinism offers a unique
opportunity to understand the intermingling of a Protestant faith,
commerce, and empire.
eBook